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Institution · Protein Technologies (United Kingdom)

Most cited papers from Protein Technologies (United Kingdom)

Protein Technologies (United Kingdom)

What are the most cited papers from Protein Technologies (United Kingdom)?

The most cited paper from Protein Technologies (United Kingdom) is "Making antibody fragments using phage display libraries" (Tim Clackson, Hennie R. Hoogenboom, Andrew D. Griffiths et al., 1991), with 1,217 citations. Next come "Conformational diversity and protein evolution – a 60-year-old hypothesis revisited" (589) and "Volume changes on protein folding" (563).

Showing 50 of 60 papers. Every paper with more than 49 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Making antibody fragments using phage display libraries Tim Clackson, Hennie R. Hoogenboom, Andrew D. Griffiths et al. · Nature Aug 1991 1,217
2 Conformational diversity and protein evolution – a 60-year-old hypothesis revisited Leo C. James, Dan S. Tawfik · Trends in Biochemical Sciences Review Jul 2003 589
3 Volume changes on protein folding Yehouda Harpaz, Mark Gerstein, Cyrus Chothia · Structure Open access Jul 1994 563
4 High-yield production of a human therapeutic protein in tobacco chloroplasts Jeffrey M. Staub, Bradley H. Garcia, Julie Graves et al. · Nature Biotechnology Mar 2000 491
5 FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality Victoria Shalhoub, Edward M. Shatzen, Sabrina C. Ward et al. · Journal of Clinical Investigation Open access 25 Jun 2012 411
6 Structural repertoire of the human VH segments Cyrus Chothia, Arthur M. Lesk, Ermanno Gherardi et al. · Journal of Molecular Biology Oct 1992 396
7 Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice Megan Lo, Hok Seon Kim, Raymond K. Tong et al. · Journal of Biological Chemistry Open access 11 Jan 2017 345
8 The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation Narender R. Gavva, Anthony W. Bannon, Sekhar Surapaneni et al. · Journal of Neuroscience Open access 28 Mar 2007 314
9 Rapid, Nongenomic Responses to Ecdysteroids and Catecholamines Mediated by a NovelDrosophilaG-Protein-Coupled Receptor Deepak P. Srivastava, Esther J. Yu, Karen Kennedy et al. · Journal of Neuroscience Open access 29 Jun 2005 289
10 β‐Glucosidase, β‐galactosidase, family A cellulases, family F xylanases and two barley glycanases form a superfamily of enzymes wit 8‐fold β/α architecture and with two conserved glutamates near the carboxy‐terminal ends of β‐strands four and seven John A. Jenkins, Leila Lo Leggio, Gillian W. Harris et al. · FEBS Letters Open access 10 Apr 1995 266
11 Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca 2+ release and apoptosis Tania Szado, Veerle Vanderheyden, Jan B. Parys et al. · Proceedings of the National Academy of Sciences Open access 4 Feb 2008 260
12 Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice Jing Qing, Xiangnan Du, Yongmei Chen et al. · Journal of Clinical Investigation Open access 16 Apr 2009 257
13 Protein folding and stability: the pathway of folding of barnase Alan Roy Fersht · FEBS Letters Open access 28 Jun 1993 247
14 Clinical evidence of efficient tumor targetting based on single–chain Fv antibody selected from a combinatorial library Richard H. J. Beǵent, Marlies J. Verhaar, Kerry Ann Chester et al. · Nature Medicine Sep 1996 242
15 Beyond micromachining: the potential of diatoms John Parkinson, Richard Gordon · Trends in biotechnology Review May 1999 227
16 In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs Joseph Cappello, John W. Crissman, Mary Crissman et al. · Journal of Controlled Release Apr 1998 226
17 Intermediate sequences increase the detection of homology between sequences Jong Moon Park, Sarah Amalia Teichmann, Tim Hubbard et al. · Journal of Molecular Biology Oct 1997 222
18 Affimer proteins are versatile and renewable affinity reagents Christian Tiede et al. · eLife Open access 8 Jun 2017 214
19 Human CD1d–glycolipid tetramers generated by in vitro oxidative refolding chromatography Anastasios Karadimitris, Stephan Donat Gadola, Myriam M. Altamirano et al. · Proceedings of the National Academy of Sciences Open access 13 Mar 2001 184
20 The growth and management of R&D outsourcing: evidence from UK pharmaceuticals Jeremy Howells, Dimitri Gagliardi, Khaleel Malik · R and D Management Open access 13 Feb 2008 172
21 Double-Hexahistidine Tag with High-Affinity Binding for Protein Immobilization, Purification, and Detection on Ni−Nitrilotriacetic Acid Surfaces Farid Khan, Mingyue He, Michael Taussig · Analytical Chemistry 5 Apr 2006 167
22 pKA Values of Carboxyl Groups in the Native and Denatured States of Barnase: The pKA Values of the Denatured State Are on Average 0.4 Units Lower Than Those of Model Compounds Mikael Oliveberg, Vickery L. Arcus, Alan R. Fersht · Biochemistry 25 Jul 1995 165
23 Circular dichroism studies of barnase and its mutants: Characterization of the contribution of aromatic side chains Stéphane Vuilleumier, Javier Monleón Sancho, Ron Loewenthal et al. · Biochemistry 5 Oct 1993 158
24 Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46) M. Kathryn Liszewski, Marilyn K. Leung, Wenying Cui et al. · Journal of Biological Chemistry Open access Dec 2000 143
25 Perturbed pKA-values in the Denatured States of Proteins Yee‐Joo Tan, Mikael Oliveberg, Ben J. Davis et al. · Journal of Molecular Biology Dec 1995 133
26 Movement of the position of the transition state in protein folding Andreas Matouschek, Daniel E. Otzen, Laura S. Itzhaki et al. · Biochemistry 17 Oct 1995 127
27 Importance of Two Buried Salt Bridges in the Stability and Folding Pathway of Barnase A. C. Tissot, Stéphane Vuilleumier, A. R. Fersht · Biochemistry 1996 125
28 Protein Stability as a Function of Denaturant Concentration: The Thermal Stability of Barnase in the Presence of Urea Christopher M. Johnson, Alan Roy Fersht · Biochemistry 23 May 1995 125
29 Vitamin E and transfer proteins Daisy E. Kaempf‐Rotzoll, Maret G. Traber, Hiroyuki Arai · Current Opinion in Lipidology 21 May 2003 121
30 Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis Steffan Vartanian, Taylur P. Ma, James Lee et al. · Molecular & Cellular Proteomics Open access 28 Dec 2015 119
31 Controlled Release of Plasmid DNA from a Genetically Engineered Silk-Elastinlike Hydrogel Zaki Megeed, Joseph Cappello, Hamidreza Ghandehari · Pharmaceutical Research Jul 2002 118
32 DNA Damage–Induced Bcl-xL Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH Rui Zhao, David Oxley, Trevor Smith et al. · PLoS Biology Open access 15 Dec 2006 116
33 Effect of soy protein on endogenous hormones in postmenopausal women Victoria Persky, Mary Ellen Turyk, Ling Wang et al. · American Journal of Clinical Nutrition Open access 2002 111
34 Pharmacological administration of granulocyte/macrophage-colony-stimulating factor is of significant importance for the induction of a strong humoral and cellular response in patients immunized with recombinant carcinoembryonic antigen Ali Samanci, Qing Yi, Jan Fagerberg et al. · Cancer Immunology Immunotherapy Open access Oct 1998 111
35 Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4 Daniela Bumbaca, Anne Wong, Elizabeth A. Drake et al. · mAbs Open access Jul 2011 110
36 Plant Breeding: Past, Present, and Future Theodore M. Crosbie, Sam R. Eathington, Gary R. Johnson et al. Conference paper 10 May 2006 101
37 Wet-Spinning of Recombinant Silk-Elastin-Like Protein Polymer Fibers with High Tensile Strength and High Deformability Weiguo Qiu, Weibing Teng, Joseph Cappello et al. · Biomacromolecules 2 Feb 2009 100
38 Scaling behaviour and rate-determining steps in filamentous self-assembly Georg Meisl, Luke Rajah, S. Cohen et al. · Chemical Science Open access 2017 98
39 In Vitro Chondrogenesis of Mesenchymal Stem Cells in Recombinant Silk-elastinlike Hydrogels Mohamed Aly Haider, Joseph Cappello, Hamidreza Ghandehari et al. · Pharmaceutical Research Open access 2 Apr 2007 91
40 Titration Properties and Thermodynamics of the Transition State for Folding: Comparison of Two-state and Multi-state Folding Pathways Yee‐Joo Tan, Mikael Oliveberg, Alan Roy Fersht · Journal of Molecular Biology Nov 1996 88
41 Gene duplications in H. influenzae Steven E. Brenner, Tim Hubbard, Alexey G. Murzin et al. · Nature 9 Nov 1995 87
42 Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants Georg Meisl, Xiaoting Yang, Christopher M. Dobson et al. · Chemical Science Open access 2017 81
43 The grounded city: from competitivity to the foundational economy Ewald Engelen, Julie Froud, Sukhdev Johal et al. · Cambridge Journal of Regions Economy and Society Open access 26 Jul 2017 80
44 The dietary-regulated biosynthesis of high-sulphur wool proteins JM Gillespie, PJ Reis · Biochemical Journal Open access Mar 1966 75
45 Thermodynamic study of the acid denaturation of barnase and its dependence on ionic strength: Evidence for residual electrostatic interactions in the acid/thermally denatured state Mikael Oliveberg, Stéphane Vuilleumier, Alan Roy Fersht · Biochemistry Jul 1994 73
46 Demonstration of a tandem pair of complement protein modules in GABAB receptor 1a Edward Hawrot, Yuanyuan Xiao, Qing-luo Shi et al. · FEBS Letters Open access 7 Aug 1998 70
47 Synthesis and highly efficient supercapacitor behavior of a novel poly pyrrole/ceramic oxide nanocomposite film Hamid Mohammad Shiri, Ali Ehsani, Javad Shabani Shayeh · RSC Advances 2015 68
48 Adenoviral Gene Delivery to Solid Tumors by Recombinant Silk–Elastinlike Protein Polymers Arash Hatefi, Joseph Cappello, Hamidreza Ghandehari · Pharmaceutical Research 16 Feb 2007 67
49 Search for Nucleation Sites in Smaller Fragments of Chymotrypsin Inhibitor 2 Laura S. Itzhaki, Jose Luis Hernandez Neira, Javier Ruiz‐Sanz et al. · Journal of Molecular Biology Nov 1995 67
50 Ribosome display: next-generation display technologies for production of antibodiesin vitro Mingyue He, Farid Khan · Expert Review of Proteomics Jun 2005 64

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.