| 1 |
Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015
Mohammad Hossein Forouzanfar et al. · JAMA
Open access |
10 Jan 2017 |
2,464 |
| 2 |
Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Nicholas J Kassebaum et al. · The Lancet
Open access349 authors |
2 May 2014 |
1,682 |
| 3 |
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Christopher J L Murray et al. · The Lancet
Open access366 authors |
21 Jul 2014 |
998 |
| 4 |
Cistrome: an integrative platform for transcriptional regulation studies
Tao Liu, Jorge Ortíz, Len Taing et al. · Genome biology
Open access |
22 Aug 2011 |
801 |
| 5 |
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
| 6 |
Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013
Hmwe Hmwe Kyu et al. · Archives of Pediatrics and Adolescent Medicine
Open access157 authors |
26 Jan 2016 |
641 |
| 7 |
PD1 blockade with pembrolizumab is highly effective in relapsed or refractory NK/T-cell lymphoma failing l-asparaginase
Yok‐Lam Kwong, Thomas S. Y. Chan, Daryl Chen Lung Tan et al. · Blood
Open access |
10 Feb 2017 |
504 |
| 8 |
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Mohsen Naghavi et al. · The Lancet
Open access2,463 authors |
Oct 2025 |
500 |
| 9 |
Child and Adolescent Health From 1990 to 2015
Nicholas J Kassebaum et al. · Archives of Pediatrics and Adolescent Medicine
Open access253 authors |
7 Apr 2017 |
447 |
| 10 |
Stroke Epidemiology in South, East, and South-East Asia: A Review
Narayanaswamy Venketasubramanian, Byung Woo Yoon, Jeyaraj Durai Pandian et al. · Journal of Stroke
Open access |
29 Sep 2017 |
423 |
| 11 |
Epidemiology of clinical benign prostatic hyperplasia
Kok Bin Lim · Asian journal of urology
Open access |
9 Jun 2017 |
392 |
| 12 |
Efficacy of pregabalin in acute postoperative pain: a meta-analysis
Jie Zhang, Kok‐Yuen Ho, Ying Wang · British Journal of Anaesthesia
ReviewOpen access |
26 Feb 2011 |
363 |
| 13 |
Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
Kie Kyon Huang et al. · Cancer Cell
Open access |
28 Dec 2017 |
336 |
| 14 |
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts
Nick A. Weaver et al. · The Lancet Neurology
Open access |
23 Apr 2021 |
330 |
| 15 |
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017
Roy Burstein et al. · Nature
Open access559 authors |
16 Oct 2019 |
280 |
| 16 |
A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study
Carol Yim-lui Cheung et al. · The Lancet Digital Health
Open access |
30 Sep 2022 |
268 |
| 17 |
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
Hweixian Leong Penny, Je Lin Sieow, Giulia Adriani et al. · OncoImmunology
Open access |
21 Jun 2016 |
265 |
| 18 |
Mechanisms of Stroke in COVID-19
J. David Spence, Gabriel R. de Freitas, Luther Creed Pettigrew et al. · Cerebrovascular Diseases
Open access |
2020 |
242 |
| 19 |
Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma
Lee Jin Lim, Samuel Yeung Shan Wong, Feiyang Huang et al. · Cancer Research
|
23 Jul 2019 |
222 |
| 20 |
Current understanding of the mixed pain concept: a brief narrative review
Rainer Freynhagen, Harold Arevalo Parada, Carlos‐Alberto Calderón‐Ospina et al. · Current Medical Research and Opinion
ReviewOpen access |
27 Nov 2018 |
220 |
| 21 |
Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
Spencer Lewis James et al. · Injury Prevention
Open access597 authors |
24 Apr 2020 |
219 |
| 22 |
Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
Azhar Ali, Elena Levantini, Jun Ting Teo et al. · EMBO Molecular Medicine
Open access |
15 Feb 2018 |
189 |
| 23 |
Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism
Ngoh Chin Liew, Gina V Alemany, Pantep Angchaisuksiri et al. · International Angiology
|
2017 |
174 |
| 24 |
Prevalence of Dementia in People Aged 60 Years and Above: Results from the WiSE Study
Mythily Subramaniam et al. · Journal of Alzheimer s Disease
|
13 Apr 2015 |
173 |
| 25 |
COVID-19: Notes From the Front Line, Singapore’s Primary Health Care Perspective
Wei Han Lim, Wei Mon Wong · The Annals of Family Medicine
Open access |
May 2020 |
158 |
| 26 |
Autophagy-mediated clearance of aggresomes is not a universal phenomenon
Esther S.P. Wong, Jeanne M.M. Tan, Wen-E Soong et al. · Human Molecular Genetics
Open access |
23 May 2008 |
158 |
| 27 |
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Dana Bryazka et al. · The Lancet Public Health
Open access1,009 authors |
Oct 2024 |
148 |
| 28 |
Cortical microinfarcts on 3T MRI: Clinical correlates in memory‐clinic patients
Susanne J. van Veluw, Saima Hilal, Hugo J. Kuijf et al. · Alzheimer s & Dementia
Open access |
5 May 2015 |
146 |
| 29 |
Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey
Yiying Cai et al. · Clinical Infectious Diseases
Open access |
31 Mar 2017 |
145 |
| 30 |
A systematic review and meta‐analysis on the effectiveness of education on medication adherence for patients with hypertension, hyperlipidaemia and diabetes
Jinhan Pamala Tan, Karis Kin Fong Cheng, Chiew Jiat Rosalind Siah · Journal of Advanced Nursing
Review |
16 Apr 2019 |
142 |
| 31 |
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)
Jonathan Wei Jie Lee et al. · Gut
Open access |
11 May 2021 |
133 |
| 32 |
Clinical profiles of multiple myeloma in Asia—An Asian Myeloma Network study
Kihyun Kım et al. · American Journal of Hematology
Open access |
9 Apr 2014 |
124 |
| 33 |
Acyclic indole and carbazole-based sulfate receptors
Philip Alan Gale, Jennifer R. Hiscock, Chen Zhu Jie et al. · Chemical Science
|
2010 |
122 |
| 34 |
Cortical cerebral microinfarcts on 3T MRI
Saima Hilal, Emiel Sikking, Muhammad Amin Shaik et al. · Neurology
Open access |
2 Sep 2016 |
121 |
| 35 |
Retinal neurodegeneration on optical coherence tomography and cerebral atrophy
Yi‐Ting Ong, Saima Hilal, Carol Yim-lui Cheung et al. · Neuroscience Letters
|
19 Oct 2014 |
121 |
| 36 |
Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study
Spencer Lewis James et al. · Injury Prevention
Open access538 authors |
24 Aug 2020 |
120 |
| 37 |
Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells*
Shiam-Peng Tay, Calvin W.S. Yeo, Chou Chai et al. · Journal of Biological Chemistry
Open access |
15 Jul 2010 |
117 |
| 38 |
Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease
Fang Ji, Ofer Pasternak, Siwei Liu et al. · Alzheimer s Research & Therapy
Open access |
17 Aug 2017 |
115 |
| 39 |
Strategies to Improve Stroke Care Services in Low- and Middle-Income Countries: A Systematic Review
Jeyaraj Durai Pandian et al. · Neuroepidemiology
ReviewOpen access |
2017 |
114 |
| 40 |
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells
Jing Zhou, Shuai-Er Hu, Shi-Hao Tan et al. · Autophagy
Open access |
19 Mar 2012 |
113 |
| 41 |
Retinal microvasculature dysfunction is associated with Alzheimer’s disease and mild cognitive impairment
Jacqueline Chua, Qinglan Hu, Mengyuan Ke et al. · Alzheimer s Research & Therapy
Open access |
Dec 2020 |
111 |
| 42 |
Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017
Juanita A. Haagsma et al. · Injury Prevention
Open access313 authors |
8 Jan 2020 |
111 |
| 43 |
Monkey business: human–animal conflicts in urban Singapore
Jun-Han Yeo, Harvey Neo · Social & Cultural Geography
|
18 Sep 2010 |
110 |
| 44 |
Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Andreas Kattem Hus⊘y et al. · The Lancet Neurology
Open access336 authors |
13 Nov 2025 |
98 |
| 45 |
Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment
Juan Wang, Reza Khosrowabadi, Kwun Kei Ng et al. · Frontiers in Aging Neuroscience
Open access |
13 Dec 2018 |
98 |
| 46 |
Markers of Cardiac Dysfunction in Cognitive Impairment and Dementia
Saima Hilal, Yuek Ling Chai, M. Kamran Ikram et al. · Medicine
Open access |
2015 |
98 |
| 47 |
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
LBD Double Burden of Malnutrition Collaborators et al. · Nature Medicine
Open access930 authors |
20 Apr 2020 |
96 |
| 48 |
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR‐targeted therapies in non‐small cell lung cancer
Dana W.Y. Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong et al. · EMBO Molecular Medicine
Open access |
30 May 2018 |
96 |
| 49 |
Microvascular network alterations in retina of subjects with cerebral small vessel disease
Saima Hilal, Yi‐Ting Ong, Carol Yim-lui Cheung et al. · Neuroscience Letters
|
16 Jun 2014 |
89 |
| 50 |
Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
Yuek Ling Chai, Joyce Ruifen Chong, Ainiah Rushdiana Raquib et al. · Scientific Reports
Open access |
17 Feb 2021 |
87 |