| 1 |
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Julian P. T. Higgins, Doug G. Altman, Peter Christian Gøtzsche et al. · BMJ
Open access |
18 Oct 2011 |
34,881 |
| 2 |
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
N.K. Aaronson, Sam Hjelmeland Ahmedzai, Bengt Bergman et al. · JNCI Journal of the National Cancer Institute
|
3 Mar 1993 |
16,252 |
| 3 |
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Clotilde Théry et al. · Journal of Extracellular Vesicles
Open access382 authors |
23 Nov 2018 |
11,535 |
| 4 |
CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials
David Moher, Sally Hopewell, Kenneth F. Schulz et al. · BMJ
Open access |
23 Mar 2010 |
9,147 |
| 5 |
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration
Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · PLoS Medicine
Open access |
10 Oct 2007 |
8,626 |
| 6 |
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Alan J. Thompson et al. · The Lancet Neurology
Open access |
21 Dec 2017 |
8,265 |
| 7 |
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
John J.V. McMurray et al. · New England Journal of Medicine
Open access |
19 Sep 2019 |
7,135 |
| 8 |
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
A.-W. Chan, Jennifer Tetzlaff, Peter Christian Gøtzsche et al. · BMJ
Open access |
9 Jan 2013 |
7,135 |
| 9 |
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes et al. · Intensive Care Medicine
Open access |
18 Jan 2017 |
6,868 |
| 10 |
European Position Paper on Rhinosinusitis and Nasal Polyps 2020
W.J. Fokkens et al. · Rhinology Journal
Open access148 authors |
Feb 2020 |
5,610 |
| 11 |
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Laura Evans et al. · Intensive Care Medicine
Open access |
2 Oct 2021 |
5,314 |
| 12 |
Standardised Nordic questionnaires for the analysis of musculoskeletal symptoms
Ilkka Kuorinka, Björn G. Jonsson, Åsa Kilbom et al. · Applied Ergonomics
|
Sep 1987 |
5,161 |
| 13 |
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Martine J Piccart et al. · New England Journal of Medicine
Open access |
20 Oct 2005 |
5,138 |
| 14 |
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*
Jean Bousquet et al. · Allergy
Open access |
7 Mar 2008 |
4,764 |
| 15 |
Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention
Pim A.L. Tonino, Bernard De Bruyne, Nico H.J. Pijls et al. · New England Journal of Medicine
Open access |
14 Jan 2009 |
4,279 |
| 16 |
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization
Veronika Whitesell Skrivankova, Rebecca Claire Richmond, Benjamin A. R. Woolf et al. · JAMA
Open access |
26 Oct 2021 |
4,188 |
| 17 |
Persistent postsurgical pain: risk factors and prevention
Henrik Kehlet, Troels Staehelin Jensen, Clifford J. Woolf · The Lancet
|
May 2006 |
4,102 |
| 18 |
Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
Sarah C. Darby, Marianne Ewertz, Paul McGale et al. · New England Journal of Medicine
Open access |
13 Mar 2013 |
4,034 |
| 19 |
The repertoire of mutational signatures in human cancer
Ludmil B. Alexandrov et al. · Nature
Open access1,384 authors |
5 Feb 2020 |
3,854 |
| 20 |
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases
Bente Klarlund Pedersen, Bengt Saltin · Scandinavian Journal of Medicine and Science in Sports
Open access |
25 Nov 2015 |
3,588 |
| 21 |
Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations
Robert H. Dworkin et al. · Journal of Pain
Open access |
13 Dec 2007 |
3,496 |
| 22 |
Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes
Peter Gæde, Henrik Lund‐Andersen, Hans‐Henrik Parving et al. · New England Journal of Medicine
Open access |
6 Feb 2008 |
3,489 |
| 23 |
Ageing as a risk factor for neurodegenerative disease
Yujun Hou, Xiuli Dan, Mansi Babbar et al. · Nature Reviews Neurology
Review |
9 Sep 2019 |
3,412 |
| 24 |
Pan-cancer analysis of whole genomes
Lauri A. Aaltonen et al. · Nature
Open access1,324 authors |
5 Feb 2020 |
3,360 |
| 25 |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
eQTLGen et al. · Nature Genetics
Open access218 authors |
26 Apr 2018 |
3,347 |
| 26 |
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences
Open access |
Apr 1990 |
3,301 |
| 27 |
Antibiotic resistance of bacterial biofilms
Niels Høiby, Thomas Bjarnsholt, Michael Givskov et al. · International Journal of Antimicrobial Agents
|
11 Feb 2010 |
3,283 |
| 28 |
ESPEN Guidelines for Nutrition Screening 2002
Jens Kondrup · Clinical Nutrition
|
22 Jul 2003 |
3,169 |
| 29 |
The anti-inflammatory effect of exercise
Anne Marie Winther Petersen, Bente Klarlund Pedersen · Journal of Applied Physiology
|
16 Mar 2005 |
3,096 |
| 30 |
Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials
Jens Kondrup · Clinical Nutrition
|
25 Mar 2003 |
3,078 |
| 31 |
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
Tomasz M. Beer et al. · New England Journal of Medicine
Open access |
Jun 2014 |
3,076 |
| 32 |
Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients
Michael J. Reardon et al. · New England Journal of Medicine
Open access |
17 Mar 2017 |
3,033 |
| 33 |
Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
Nadja Larsen, Finn Kvist Vogensen, Frans W.J. van den Berg et al. · PLoS ONE
Open access |
4 Feb 2010 |
3,014 |
| 34 |
SignalP 6.0 predicts all five types of signal peptides using protein language models
Felix Teufel, José Juan Almagro Armenteros, Alexander Rosenberg Johansen et al. · Nature Biotechnology
Open access |
3 Jan 2022 |
2,998 |
| 35 |
Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
H. J. G. Gundersen, Thomas Fichtner Bendtsen, Lise Korbo et al. · Apmis
|
1988 |
2,964 |
| 36 |
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Bente Klarlund Pedersen, Mark Anthony Febbraio · Nature Reviews Endocrinology
Review |
3 Apr 2012 |
2,921 |
| 37 |
When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts
Janus Christian Jakobsen, Christian Nyfeldt Gluud, Jørn Wetterslev et al. · BMC Medical Research Methodology
Open access |
Dec 2017 |
2,864 |
| 38 |
An atlas of active enhancers across human cell types and tissues
Robin Andersson et al. · Nature
Open access |
Mar 2014 |
2,854 |
| 39 |
Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children
Alexander Edward Dela Cruz Drilon et al. · New England Journal of Medicine
Open access |
21 Feb 2018 |
2,827 |
| 40 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update
Josef S Smolen et al. · Annals of the Rheumatic Diseases
Open access |
22 Jan 2020 |
2,807 |
| 41 |
Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest
Niklas Nielsen et al. · New England Journal of Medicine
Open access |
17 Nov 2013 |
2,799 |
| 42 |
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society
Børge Grønne Nordestgaard et al. · European Heart Journal
Open access |
15 Aug 2013 |
2,797 |
| 43 |
Fractional Flow Reserve–Guided PCI versus Medical Therapy in Stable Coronary Disease
Bernard De Bruyne et al. · New England Journal of Medicine
Open access |
28 Aug 2012 |
2,784 |
| 44 |
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)
Jan Paul Vandenbroucke, Erik B von Elm, Douglas G. Altman et al. · Epidemiology
Open access |
Nov 2007 |
2,777 |
| 45 |
Evidence for decreasing quality of semen during past 50 years.
Elisabeth Carlsen, Aleksander Giwercman, Niels Keiding et al. · BMJ
Open access |
12 Sep 1992 |
2,775 |
| 46 |
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Martin Aringer et al. · Arthritis & Rheumatology
Open access |
6 Aug 2019 |
2,644 |
| 47 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez et al. · Nature Genetics
Open access1,266 authors |
Apr 2022 |
2,608 |
| 48 |
Postoperative Radiotherapy in High-Risk Premenopausal Women with Breast Cancer Who Receive Adjuvant Chemotherapy
Marie Overgaard, Per Syrak Hansen, Jens Overgaard et al. · New England Journal of Medicine
|
2 Oct 1997 |
2,591 |
| 49 |
Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
Lesley J. Wood, Matthias Egger, Lise Lotte Gluud et al. · BMJ
Open access |
3 Mar 2008 |
2,582 |
| 50 |
The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
H.J.G. Gundersen, Peter Valdemar Bagger, Thomas Fichtner Bendtsen et al. · Apmis
|
Jul 1988 |
2,506 |