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Most cited papers from Science for Life Laboratory

What are the most cited papers from Science for Life Laboratory?

The most cited paper from Science for Life Laboratory is "Full-length transcriptome assembly from RNA-Seq data without a reference genome" (Manfred G. Grabherr et al., 2011), with 23,028 citations. Next come "Tissue-based map of the human proteome" (16,343) and "MultiQC: summarize analysis results for multiple tools and samples in a single report" (11,105).

Showing 50 of 59 papers. Every paper with more than 1,398 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Full-length transcriptome assembly from RNA-Seq data without a reference genome Manfred G. Grabherr et al. · Nature Biotechnology Open access 15 May 2011 23,028
2 Tissue-based map of the human proteome Mathias Uhlén et al. · Science Open access 22 Jan 2015 16,343
3 MultiQC: summarize analysis results for multiple tools and samples in a single report Philip Ewels, Måns Magnusson, Sverker Lundin et al. · Bioinformatics Open access 16 Jun 2016 11,105
4 De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis Brian J. Haas et al. · Nature Protocols Open access 11 Jul 2013 9,312
5 SignalP 4.0: discriminating signal peptides from transmembrane regions Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne et al. · Nature Methods 29 Sep 2011 9,256
6 Pfam: The protein families database in 2021 Jaina Mistry, Sara Chuguransky, Lowri Williams et al. · Nucleic Acids Research Open access 6 Oct 2020 8,165
7 GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit Sander Pronk, Szilárd Páll, Roland Schulz et al. · Bioinformatics Open access 13 Feb 2013 7,730
8 Pfam: the protein families database ROBERT FINN, Alex Bateman, Jody Clements et al. · Nucleic Acids Research Open access 27 Nov 2013 6,604
9 Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science Emily Alexandra Holmes et al. · The Lancet Psychiatry Open access 15 Apr 2020 6,092
10 New tools for automated high-resolution cryo-EM structure determination in RELION-3 Jasenko Zivanov, Takanori Nakane, Björn O. Forsberg et al. · eLife Open access 9 Nov 2018 5,552
11 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project Ewan Birney et al. · Nature Open access312 authors Jun 2007 5,310
12 The Pfam protein families database in 2019 Sara El-Gebali, Jaina Mistry, Alex Bateman et al. · Nucleic Acids Research Open access 9 Oct 2018 5,256
13 Genetic studies of body mass index yield new insights for obesity biology The LifeLines Cohort Study et al. · Nature Open access487 authors 10 Feb 2015 4,954
14 SignalP 5.0 improves signal peptide predictions using deep neural networks José Juan Almagro Armenteros, Konstantinos D. Tsirigos, Casper Kaae Sønderby et al. · Nature Biotechnology Open access 18 Feb 2019 4,807
15 RNA velocity of single cells Gioele La Manno et al. · Nature Open access 7 Aug 2018 4,678
16 The nf-core framework for community-curated bioinformatics pipelines Philip Ewels, Alexander Peltzer, Sven Fillinger et al. · Nature Biotechnology Open access 13 Feb 2020 4,389
17 Visualization and analysis of gene expression in tissue sections by spatial transcriptomics Patrik L. Ståhl et al. · Science 30 Jun 2016 4,138
18 Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics Linn Fagerberg et al. · Molecular & Cellular Proteomics Open access 5 Dec 2013 3,874
19 The repertoire of mutational signatures in human cancer Ludmil B. Alexandrov et al. · Nature Open access1,384 authors 5 Feb 2020 3,854
20 A pathology atlas of the human cancer transcriptome Mathias Uhlén et al. · Science Open access 17 Aug 2017 3,597
21 Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence Giulio Genovese et al. · New England Journal of Medicine Open access 26 Nov 2014 3,589
22 Clumpak : a program for identifying clustering modes and packaging population structure inferences across K Naama Meira Kopelman, Jonathan Mayzel, Mattias Jakobsson et al. · Molecular Ecology Resources Open access 13 Feb 2015 3,416
23 Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature Open access1,324 authors 5 Feb 2020 3,360
24 Discovery and refinement of loci associated with lipid levels Cristen J. Willer et al. · Nature Genetics Open access259 authors 6 Oct 2013 3,319
25 Binning metagenomic contigs by coverage and composition Johannes Alneberg, Brynjar Smári Bjarnason, Ino de Bruijn et al. · Nature Methods Open access 14 Sep 2014 3,116
26 A subcellular map of the human proteome Peter J. Thul et al. · Science 11 May 2017 3,046
27 Transitions in bacterial communities along the 2000 km salinity gradient of the Baltic Sea Daniel P. R. Herlemann, Matthias Labrenz, Klaus Jürgens et al. · The ISME Journal Open access 7 Apr 2011 3,025
28 SignalP 6.0 predicts all five types of signal peptides using protein language models Felix Teufel, José Juan Almagro Armenteros, Alexander Rosenberg Johansen et al. · Nature Biotechnology Open access 3 Jan 2022 2,998
29 A survey of best practices for RNA-seq data analysis Ana Conesa, Pedro Madrigal, Sonia Tarazona et al. · Genome biology Open access 26 Jan 2016 2,977
30 Autoantibodies against type I IFNs in patients with life-threatening COVID-19 Paul Bastard et al. · Science Open access752 authors 24 Sep 2020 2,885
31 Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea Robert M. Bowers et al. · Nature Biotechnology Open access Aug 2017 2,869
32 Trends in GPCR drug discovery: new agents, targets and indications Alexander S. Hauser, Misty M. Attwood, Mathias Rask‐Andersen et al. · Nature Reviews Drug Discovery ReviewOpen access 27 Oct 2017 2,779
33 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Stephen J. Sawcer et al. · Nature Open access241 authors Aug 2011 2,772
34 A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease Majid Nikpay et al. · Nature Genetics ReviewOpen access151 authors 7 Sep 2015 2,733
35 Towards a knowledge-based Human Protein Atlas Mathias Uhlén, Per Oksvold, Linn Fagerberg et al. · Nature Biotechnology Open access Dec 2010 2,550
36 The Human Cell Atlas Aviv Regev et al. · eLife Open access 5 Dec 2017 2,441
37 A promoter-level mammalian expression atlas Alistair R. R. Forrest et al. · Nature Open access261 authors Mar 2014 2,221
38 Transcriptome and genome sequencing uncovers functional variation in humans Tuuli Lappalainen et al. · Nature Open access Sep 2013 2,200
39 Evolution of genes and genomes on the Drosophila phylogeny Andrew G. Clark et al. · Nature Open access415 authors Nov 2007 2,132
40 Defining the role of common variation in the genomic and biological architecture of adult human height Andrew R. Wood et al. · Nature Genetics 446 authors 5 Oct 2014 2,114
41 Tumor angiogenesis: causes, consequences, challenges and opportunities Roberta Lugano, Mohanraj Ramachandran, Anna Dimberg · Cellular and Molecular Life Sciences Open access 6 Nov 2019 2,006
42 Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps Anubha Mahajan et al. · Nature Genetics Open access115 authors Oct 2018 1,968
43 The genomic basis of adaptive evolution in threespine sticklebacks Felicity C. Jones et al. · Nature Open access Apr 2012 1,956
44 A single-cell and spatially resolved atlas of human breast cancers Sunny Z. Wu et al. · Nature Genetics Open access Sep 2021 1,918
45 A single–cell type transcriptomics map of human tissues Max Karlsson et al. · Science Advances Open access 28 Jul 2021 1,911
46 Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays Ao Chen et al. · Cell Open access May 2022 1,872
47 Genome-wide association studies Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung et al. · Nature Reviews Methods Primers ReviewOpen access 26 Aug 2021 1,869
48 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Rainer Malik et al. · Nature Genetics Open access428 authors 12 Mar 2018 1,753
49 New genetic loci link adipose and insulin biology to body fat distribution Dmitry Shungin et al. · Nature Open access410 authors 10 Feb 2015 1,726
50 The Norway spruce genome sequence and conifer genome evolution Björn Nystedt et al. · Nature Open access May 2013 1,574

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.