| 1 |
Health benefits of physical activity: the evidence
Darren E. R. Warburton · Canadian Medical Association Journal
Open access |
13 Mar 2006 |
8,106 |
| 2 |
Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery
Martin B. Leon et al. · New England Journal of Medicine
Open access |
20 Oct 2010 |
7,239 |
| 3 |
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Ravindra L. Mehta, John A. Kellum, Sudhir V. Shah et al. · Critical Care
Open access |
Mar 2007 |
7,137 |
| 4 |
Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
Craig R. Smith et al. · New England Journal of Medicine
Open access |
5 Jun 2011 |
6,389 |
| 5 |
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
James C. Hogg, Fanny S. F. Chu, Soraya Utokaparch et al. · New England Journal of Medicine
Open access |
23 Jun 2004 |
3,801 |
| 6 |
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary
Claus Franz Vogelmeier et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
Mar 2017 |
3,296 |
| 7 |
Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement
Susheel Kodali et al. · New England Journal of Medicine
Open access |
26 Mar 2012 |
2,308 |
| 8 |
Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial
Jean–Frédéric Colombel, William J. Sandborn, Paul J. Rutgeerts et al. · Gastroenterology
Open access |
30 Nov 2006 |
2,263 |
| 9 |
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
Wenqi Gan · Thorax
ReviewOpen access |
28 Jun 2004 |
1,854 |
| 10 |
Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality*
John H. Boyd, Jason Forbes, Taka‐aki Nakada et al. · Critical Care Medicine
|
23 Oct 2010 |
1,550 |
| 11 |
Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery Disease
Bjarne Linde Nørgaard, Jonathon A Leipsic, Sara Gaur et al. · Journal of the American College of Cardiology
Open access |
31 Jan 2014 |
1,498 |
| 12 |
The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL)
Milada Dobiášová, Jiri J Frohlich · Clinical Biochemistry
|
Oct 2001 |
1,492 |
| 13 |
Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis
Raj Makkar et al. · New England Journal of Medicine
Open access |
26 Mar 2012 |
1,354 |
| 14 |
Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
Alvar G.N. Agustí et al. · European Respiratory Journal
Open access |
Mar 2023 |
1,320 |
| 15 |
Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research
Philippe Généreux et al. · Journal of the American College of Cardiology
Open access |
19 Apr 2021 |
1,302 |
| 16 |
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
James C. Hogg · The Lancet
|
Aug 2004 |
1,295 |
| 17 |
Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough, Ren Yuan, Masaru Suzuki et al. · New England Journal of Medicine
Open access |
26 Oct 2011 |
1,225 |
| 18 |
Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock
Anand Kumar, Anand Kumar, Paul Ellis et al. · CHEST Journal
|
20 Aug 2009 |
1,209 |
| 19 |
2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult
Todd J. Anderson et al. · Canadian Journal of Cardiology
|
26 Jul 2016 |
1,183 |
| 20 |
Management of Sepsis
James A. Russell · New England Journal of Medicine
|
18 Oct 2006 |
1,053 |
| 21 |
Celecoxib for the Prevention of Sporadic Colorectal Adenomas
Monica M. Bertagnolli et al. · New England Journal of Medicine
Open access |
30 Aug 2006 |
1,047 |
| 22 |
Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper
David A. Lynch, Nicola Sverzellati, William David Travis et al. · The Lancet Respiratory Medicine
Open access |
15 Nov 2017 |
1,042 |
| 23 |
Mortality in COPD: role of comorbidities
Don D. Sin, N. R. Anthonisen, Joan Bautista Soriano et al. · European Respiratory Journal
Open access |
30 Nov 2006 |
1,025 |
| 24 |
Percutaneous Transarterial Aortic Valve Replacement in Selected High-Risk Patients With Aortic Stenosis
John G. Webb, Sanjeevan Pasupati, Karin H. Humphries et al. · Circulation
Open access |
23 Jul 2007 |
1,022 |
| 25 |
Transcatheter Aortic Valve Implantation for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at Very High or Prohibitive Surgical Risk
Josep Rodés‐Cabau et al. · Journal of the American College of Cardiology
Open access |
25 Jan 2010 |
981 |
| 26 |
Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease
Kazuhiro Ito, Misako Ito, W. Mark Elliott et al. · New England Journal of Medicine
Open access |
11 May 2005 |
974 |
| 27 |
Global burden of COPD
José Luís López-Campos, Wan Cheng Tan, Joan Bautista Soriano · Respirology
Open access |
23 Oct 2015 |
945 |
| 28 |
Natalizumab Induction and Maintenance Therapy for Crohn's Disease
William J. Sandborn, Jean‐Frédéric Colombel, Roberts Enns et al. · New England Journal of Medicine
Open access |
2 Nov 2005 |
929 |
| 29 |
Enfuvirtide, an HIV-1 Fusion Inhibitor, for Drug-Resistant HIV Infection in North and South America
Jacob Paul Lalezari, Keith Henry, Mary O’Hearn et al. · New England Journal of Medicine
Open access |
28 May 2003 |
920 |
| 30 |
Percutaneous Aortic Valve Implantation Retrograde From the Femoral Artery
John G. Webb, Mann Chandavimol, Christopher Thompson et al. · Circulation
Open access |
7 Feb 2006 |
905 |
| 31 |
The Relationship Between Reduced Lung Function and Cardiovascular Mortality
Don D. Sin, LieLing Wu, S. F. Paul Man · CHEST Journal
|
Jun 2005 |
890 |
| 32 |
Improved Survival Among HIV-Infected Individuals Following Initiation of Antiretroviral Therapy
Robert S. Hogg · JAMA
|
11 Feb 1998 |
869 |
| 33 |
2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults
Glen J. Pearson et al. · Canadian Journal of Cardiology
Open access |
27 Mar 2021 |
861 |
| 34 |
The Pathology of Chronic Obstructive Pulmonary Disease
James C. Hogg, Wim Timens · Annual Review of Pathology Mechanisms of Disease
Review |
27 Oct 2008 |
860 |
| 35 |
The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis
Gordon R. Bernard, Arthur P. Wheeler, James A. Russell et al. · New England Journal of Medicine
|
27 Mar 1997 |
840 |
| 36 |
An integrated cell atlas of the lung in health and disease
Lisa Sikkema et al. · Nature Medicine
Open access |
Jun 2023 |
834 |
| 37 |
Frailty in Older Adults Undergoing Aortic Valve Replacement
Jonathan Afilalo et al. · Journal of the American College of Cardiology
Open access |
7 Jul 2017 |
815 |
| 38 |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James McKay et al. · Nature Genetics
Open access140 authors |
12 Jun 2017 |
808 |
| 39 |
The Mechanics of Airway Narrowing in Asthma
Alan L. James, Peter D. Paré, James C. Hogg · American Review of Respiratory Disease
|
1989 |
792 |
| 40 |
2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult
Todd J. Anderson et al. · Canadian Journal of Cardiology
|
23 Jan 2013 |
775 |
| 41 |
2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations
Jacques J. Genest et al. · Canadian Journal of Cardiology
Open access |
Oct 2009 |
772 |
| 42 |
Staging classification of aortic stenosis based on the extent of cardiac damage
Philippe Généreux et al. · European Heart Journal
Open access |
18 Jun 2017 |
752 |
| 43 |
Chronic Kidney Disease and Coronary Artery Disease
Mark J. Sarnak et al. · Journal of the American College of Cardiology
Open access |
30 Sep 2019 |
749 |
| 44 |
Enhancing a Somatic Maturity Prediction Model
Sarah A. Moore, Heather A. McKay, HEATHER M. MACDONALD et al. · Medicine & Science in Sports & Exercise
Open access |
25 Nov 2014 |
742 |
| 45 |
Rates of Disease Progression by Baseline CD4 Cell Count and Viral Load After Initiating Triple-Drug Therapy
Robert S. Hogg · JAMA
|
28 Nov 2001 |
736 |
| 46 |
Prevalent left ventricular hypertrophy in the predialysis population: Identifying opportunities for intervention
Adeera Levin, Joel Singer, Christopher Thompson et al. · American Journal of Kidney Diseases
|
Mar 1996 |
715 |
| 47 |
Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis
Manish Motwani et al. · European Heart Journal
Open access |
Jun 2016 |
709 |
| 48 |
National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines for Chronic Kidney Disease in Children and Adolescents: Evaluation, Classification, and Stratification
Ronald J. Hogg, Susan L. Furth, Kevin V. Lemley et al. · PEDIATRICS
|
Jun 2003 |
705 |
| 49 |
Computed Tomographic Measurements of Airway Dimensions and Emphysema in Smokers
Yasutaka Nakano, Shigeo Muro, Hiroaki Sakai et al. · American Journal of Respiratory and Critical Care Medicine
|
Sep 2000 |
699 |
| 50 |
Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report
Claus Franz Vogelmeier et al. · Respirology
|
2 Feb 2017 |
697 |