| 1 |
The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises
Srinivasa Naga Raja, Daniel B. Carr, Milton L Cohen et al. · Pain
Open access |
16 Jul 2020 |
5,173 |
| 2 |
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter J. Bailey et al. · Nature
103 authors |
23 Feb 2016 |
3,805 |
| 3 |
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki et al. · Nature
|
16 Sep 2015 |
3,790 |
| 4 |
Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)
Rolf‐Detlef Treede et al. · Pain
Open access |
22 Dec 2018 |
3,452 |
| 5 |
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Kendle M. Maslowski, Angelica Thomas Vieira, Aylwin Ng et al. · Nature
Open access |
Oct 2009 |
3,283 |
| 6 |
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Paul Bastard et al. · Science
Open access752 authors |
24 Sep 2020 |
2,885 |
| 7 |
A classification of chronic pain for ICD-11
Rolf‐Detlef Treede et al. · Pain
Open access |
6 Apr 2015 |
2,856 |
| 8 |
Endogenous microRNA sponges: evidence and controversy
Daniel W. Thomson, Marcel E. Dinger · Nature Reviews Genetics
ReviewOpen access |
4 Apr 2016 |
2,402 |
| 9 |
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton et al. · Nature
Open access239 authors |
27 May 2007 |
2,342 |
| 10 |
An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction
Bernard T. Haylen, Dirk J. M. K. De Ridder, Robert M. Freeman et al. · International Urogynecology Journal
|
24 Nov 2009 |
2,232 |
| 11 |
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Australian Pancreatic Cancer Genome Initiative et al. · Nature
Open access127 authors |
24 Oct 2012 |
2,133 |
| 12 |
Pre-metastatic niches: organ-specific homes for metastases
Héctor Peinado, Haiying Zhang, Irina R. Matei et al. · Nature reviews. Cancer
ReviewOpen access |
17 Mar 2017 |
1,930 |
| 13 |
A single-cell and spatially resolved atlas of human breast cancers
Sunny Z. Wu et al. · Nature Genetics
Open access |
Sep 2021 |
1,918 |
| 14 |
Adherence to Continuous Positive Airway Pressure Therapy: The Challenge to Effective Treatment
Terri E. Weaver, Ronald R. Grunstein · Proceedings of the American Thoracic Society
Open access |
Feb 2008 |
1,673 |
| 15 |
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Ruth Pidsley, Elena Zotenko, Timothy J. Peters et al. · Genome biology
Open access |
7 Oct 2016 |
1,670 |
| 16 |
The IASP classification of chronic pain for ICD-11: chronic primary pain
Michael K. Nicholas, Johan W.S. Vlaeyen, Winfried Rief et al. · Pain
Open access |
22 Dec 2018 |
1,433 |
| 17 |
Cyclin D as a therapeutic target in cancer
Elizabeth A. Musgrove, C. Elizabeth Caldon, Jane Barraclough et al. · Nature reviews. Cancer
Review |
7 Jul 2011 |
1,383 |
| 18 |
Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis
C Vlachopoulos, Konstantinos A. Aznaouridis, Michael F. O’Rourke et al. · European Heart Journal
ReviewOpen access |
2 Mar 2010 |
1,370 |
| 19 |
Clinical Pharmacokinetics of Metformin
Garry G. Graham, Jeroen Punt, Manit Arora et al. · Clinical Pharmacokinetics
|
18 Jan 2011 |
1,320 |
| 20 |
Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
Sudarshan Paramsothy, Michael A. Kamm, Nadeem O. Kaakoush et al. · The Lancet
|
15 Feb 2017 |
1,292 |
| 21 |
Biological determinants of endocrine resistance in breast cancer
Elizabeth A. Musgrove, Robert L. Sutherland · Nature reviews. Cancer
Review |
24 Aug 2009 |
1,275 |
| 22 |
The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
Di Yu, Sudha Rao, Louis M. Tsai et al. · Immunity
Open access |
24 Jul 2009 |
1,250 |
| 23 |
Mechanical Factors in Arterial Aging
Michael F. O’Rourke, Junichiro Hashimoto · Journal of the American College of Cardiology
Open access |
19 Jun 2007 |
1,246 |
| 24 |
Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee
Stuart G. Tangye, Waleed Al–Herz, Aziz A. Bousfiha et al. · Journal of Clinical Immunology
Open access |
2020 |
1,238 |
| 25 |
Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee
Stuart G. Tangye, Waleed Al–Herz, Aziz A. Bousfiha et al. · Journal of Clinical Immunology
Open access |
24 Jun 2022 |
1,189 |
| 26 |
The IASP classification of chronic pain for ICD-11: chronic neuropathic pain
Joachim Scholz et al. · Pain
Open access |
22 Dec 2018 |
1,186 |
| 27 |
Prospective Evaluation of a Method for Estimating Ascending Aortic Pressure From the Radial Artery Pressure Waveform
Alfredo L. Pauca, Michael F. O’Rourke, Neal D. Kon · Hypertension
Open access |
Oct 2001 |
1,181 |
| 28 |
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Angela M Wood et al. · The Lancet
Open access246 authors |
Apr 2018 |
1,177 |
| 29 |
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
Mara H. Sherman et al. · Cell
Open access |
Sep 2014 |
1,153 |
| 30 |
Clinical applications of arterial stiffness; definitions and reference values
M. F. O'Rourke, Jan A. Staessen, Charalampos Vlachopoulos et al. · American Journal of Hypertension
Open access |
May 2002 |
1,096 |
| 31 |
Arterial Stiffness, Wave Reflections, and the Risk of Coronary Artery Disease
THOMAS R. WEBER, Johann Auer, Michael F. O’Rourke et al. · Circulation
Open access |
9 Dec 2003 |
1,085 |
| 32 |
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
Jeffrey E. Squires, Hardip R. Patel, Marco Nousch et al. · Nucleic Acids Research
Open access |
16 Feb 2012 |
1,080 |
| 33 |
De novo identification of differentially methylated regions in the human genome
Timothy J. Peters, Michael J Buckley, Aaron L. Statham et al. · Epigenetics & Chromatin
Open access |
27 Jan 2015 |
1,071 |
| 34 |
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Rebecca C. Coll, James R. Hill, Christopher J. Day et al. · Nature Chemical Biology
Open access |
13 May 2019 |
1,046 |
| 35 |
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Chansavath Phetsouphanh, David Ross Darley, Daniel B. Wilson et al. · Nature Immunology
Open access |
13 Jan 2022 |
1,038 |
| 36 |
The matrix in cancer
Thomas R. Cox · Nature reviews. Cancer
Review |
15 Feb 2021 |
1,015 |
| 37 |
Do we need a third mechanistic descriptor for chronic pain states?
Eva Kosek, Milton L Cohen, Ralf Baron et al. · Pain
|
30 Jan 2016 |
961 |
| 38 |
Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events
Rachael A. McCloy, Samuel Rogers, C. Elizabeth Caldon et al. · Cell Cycle
Open access |
6 Mar 2014 |
892 |
| 39 |
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Hye Sun Kuehn et al. · Science
Open access |
12 Sep 2014 |
865 |
| 40 |
The Human Phenotype Ontology in 2017
Sebastian Köhler et al. · Nucleic Acids Research
Open access |
28 Nov 2016 |
819 |
| 41 |
International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity
Capucine Pïcard, Hubert Bobby Gaspar, Waleed Al–Herz et al. · Journal of Clinical Immunology
Open access |
11 Dec 2017 |
811 |
| 42 |
The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation
Charalambos V. Vlachopoulos et al. · Atherosclerosis
Open access |
16 May 2015 |
725 |
| 43 |
RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure
Zhipeng Lu, Qiangfeng Cliff Zhang, Byron Lee et al. · Cell
Open access |
May 2016 |
721 |
| 44 |
hERG K + Channels: Structure, Function, and Clinical Significance
Jamie I. Vandenberg, Matthew Perry, Mark J. Perrin et al. · Physiological Reviews
Review |
Jul 2012 |
718 |
| 45 |
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
Martin Whitham, Benjamin L. Parker, Martin Haljeta Friedrichsen et al. · Cell Metabolism
Open access |
2018 |
700 |
| 46 |
Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification
Aziz A. Bousfiha, Leïla Jeddane, Capucine Pïcard et al. · Journal of Clinical Immunology
Open access |
2020 |
699 |
| 47 |
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
Kevin Mulder et al. · Immunity
Open access |
30 Jul 2021 |
698 |
| 48 |
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
Carrie L. Lucas et al. · Nature Immunology
Open access |
28 Oct 2013 |
681 |
| 49 |
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
Garry G. Graham, Michael J. Davies, Richard Osborne Day et al. · Inflammopharmacology
|
29 May 2013 |
672 |
| 50 |
Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
Jing He et al. · Immunity
Open access |
Oct 2013 |
662 |