Most cited papers from Synthon (Netherlands)

Synthon (Netherlands)

What are the most cited papers from Synthon (Netherlands)?

The most cited paper from Synthon (Netherlands) is "Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study" (Udai Banerji, Carla M.L. van Herpen, Cristina Saura et al., 2019), with 577 citations. Next come "Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985" (225) and "The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers" (218).

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Showing 50 of 62 papers. Every paper with more than 21 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study Udai Banerji, Carla M.L. van Herpen, Cristina Saura et al. · The Lancet Oncology Open access	27 Jun 2019	577
2	Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 Ronald C. Elgersma, Ruud G. E. Coumans, Tijl Huijbregts et al. · Molecular Pharmaceutics Open access	30 Jan 2015	225
3	The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers Miranda M.C. van der Lee, Patrick G. Groothuis, Ruud Ubink et al. · Molecular Cancer Therapeutics	14 Jan 2015	218
4	Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform Wim H.A. Dokter et al. · Molecular Cancer Therapeutics Open access	5 Sep 2014	168
5	Novel astaxanthin extraction from Haematococcus pluvialis using cell permeabilising ionic liquids Rupali K. Desai, Mathieu Streefland, René H. Wijffels et al. · Green Chemistry Open access	29 Sep 2015	155
6	Metabolic characterization of a CHO cell size increase phase in fed-batch cultures Xiao Pan, Ciska Dalm, René H. Wijffels et al. · Applied Microbiology and Biotechnology Open access	26 Sep 2017	143
7	A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours Mark T. J. van Bussel, Ahmad Hussein Awada, Maja J.A. de Jonge et al. · British Journal of Cancer Open access	23 Nov 2020	130
8	Extraction and stability of selected proteins in ionic liquid based aqueous two phase systems Rupali K. Desai, Mathieu Streefland, René H. Wijffels et al. · Green Chemistry Open access	2014	129
9	NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods Maria Lorna A. De Leoz et al. · Molecular & Cellular Proteomics Open access162 authors	7 Oct 2019	126
10	Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? Sun‐Wei Guo, Patrick G. Groothuis · Human Reproduction Update Open access	21 May 2018	101
11	Elucidation of the Primary Structure of the Lantibiotic Epilancin K7 from Staphylococcus epidermidis K7. Cloning and Characterisation of the Epilancin-K7-Encoding Gene and NMR Analysis of Mature Epilancin K7 Mart van de Kamp, Henno W. van den Hooven, Ruud N.H. Konings et al. · European Journal of Biochemistry Open access	Jun 1995	100
12	SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody–Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression Jonathan T. Black et al. · Molecular Cancer Therapeutics Open access	2 Jun 2016	93
13	1,3-Dipolar cycloaddition reactions of nitrones with alkyl vinyl ethers catalyzed by chiral oxazaborolidines Jean-Paul G. Seerden, Mike M.M. Boeren, Hans W. Scheeren · Tetrahedron	Aug 1997	88
14	Development and validation of a simple HPLC method for simultaneous in vitro determination of amoxicillin and metronidazole at single wavelength Naser Tavakoli, Jaleh Varshosaz, Farid Abedin Dorkoosh et al. · Journal of Pharmaceutical and Biomedical Analysis	22 Jul 2006	88
15	The three‐dimensional structure of a DNA hairpin in solution Marcel J. J. Blommers, Frank J. M. VAN DE VEN, Gÿs A. VAN DER MAREL et al. · European Journal of Biochemistry Open access	Oct 1991	85
16	Optimization of biopharmaceutical downstream processes supported by mechanistic models and artificial neural networks Silvia M. Pirrung, Luuk A. M. van der Wielen, Ruud F. W. C. van Beckhoven et al. · Biotechnology Progress	5 Jan 2017	82
17	Supercontracted spider dragline silk: a solid-state NMR study of the local structure Jacco D. van Beek, Jörg Kümmerlen, Fritz W. Vollrath et al. · International Journal of Biological Macromolecules	Mar 1999	78
18	Equivalence of Generic Glatiramer Acetate in Multiple Sclerosis Jeffrey Allen Cohen, Anna N. Belova, Krzysztof W. Selmaj et al. · JAMA Neurology Open access	13 Oct 2015	78
19	Selection of chemically defined media for CHO cell fed-batch culture processes Xiao Pan, Mathieu Streefland, Ciska Dalm et al. · Cytotechnology Open access	29 Nov 2016	73
20	Crystal Growth and Morphology: New Developments in an Integrated Hartman−PerdokConnected NetRoughening Transition Theory, Supported by Computer Simulations Piet Bennema, Hugo Meekes, S. X. M. Boerrigter et al. · Crystal Growth & Design Open access	2 Jul 2004	61
21	Continuous nondestructive monitoring of Bordetella pertussis biofilms by Fourier transform infrared spectroscopy and other corroborative techniques Diego O. Serra, Alejandra Bosch, Daniela Marta Russo et al. · Analytical and Bioanalytical Chemistry Open access	9 Jan 2007	60
22	The solution structure of the circular trinucleotide cr(GpGpGp) determined by NMR and molecular mechanics calculation M.M.W. Mooren, Sybren S. Wijmenga, Gijs A. van der Marel et al. · Nucleic Acids Research Open access	1994	59
23	Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM‐775) Simon D. Brandt, Pierce V. Kavanagh, Brendan Twamley et al. · Drug Testing and Analysis Open access	5 Jun 2017	58
24	The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1 Mercedes Nadal‐Serrano, Beatriz Morancho, Santiago Escrivá-de-Romaní et al. · Cancers Open access	13 Mar 2020	57
25	A Heterogeneously Structured Composite Based on Poly(lactic-co-glycolic acid) Microspheres and Poly(vinyl alcohol) Hydrogel Nanoparticles for Long-Term Protein Drug Delivery Nuo Wang, Xue Shen Wu, Jiakui Li · Pharmaceutical Research	Sep 1999	56
26	Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability Marie-Therese Schermeyer, Anna Katharina Wöll, Bas P.A. Kokke et al. · mAbs Open access	15 Jun 2017	55
27	Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting Saskia Meyer, Maaike Nederend, J.H. Marco Jansen et al. · mAbs Open access	14 Oct 2015	55
28	Solubility of molecular crystals: Polymorphism in the light of solubility theory Pieter Bennema, J VANEUPEN, B VANDERWOLF et al. · International Journal of Pharmaceutics Open access	26 Sep 2007	55
29	The detailed structure of tandem G·A mismatched base-pair motifs in RNA duplexes is context dependent Hans A. Heus, Sybren S. Wijmenga, Hans Hoppe et al. · Journal of Molecular Biology	Aug 1997	54
30	Unraveling the Interaction between Carboxylesterase 1c and the Antibody–Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice Ruud Ubink, Eef H.C. Dirksen, Myrthe Rouwette et al. · Molecular Cancer Therapeutics Open access	9 Aug 2018	51
31	Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing Arianne M. Brandsma, Toine ten Broeke, Maaike Nederend et al. · Cancer Immunology Research Open access	25 Sep 2015	50
32	Rubisco separation using biocompatible aqueous two-phase systems Catalina A. Suarez Ruiz, Corjan van den Berg, René H. Wijffels et al. · Separation and Purification Technology Open access	3 May 2017	49
33	Palladium-Catalyzed Cyclization Reactions of Acetylene-Containing Amino Acids Larissa B. Wolf, Kim C. M. F. Tjen, Hefziba T. ten Brink et al. · Advanced Synthesis & Catalysis	2002	49
34	The effect of dialectical behaviour therapy in autism spectrum patients with suicidality and/ or self-destructive behaviour (DIASS): study protocol for a multicentre randomised controlled trial Anne Huntjens, L. M. C. Wies van den Bosch, Bram B. Sizoo et al. · BMC Psychiatry Open access	17 Mar 2020	48
35	A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA Gerard Rouwendal, Miranda MC van der Lee, Saskia Meyer et al. · mAbs Open access	6 Oct 2015	48
36	Novel 20-Carbonate Linked Prodrugs of Camptothecin and 9-Aminocamptothecin Designed for Activation by Tumour-Associated Plasmin Franciscus M. H. de Groot, Guuske F. Busscher, Rene W. M. Aben et al. · Bioorganic & Medicinal Chemistry Letters	Sep 2002	48
37	Broadband dipolar recoupling in rotating solids: a numerical comparison of some pulse schemes Marc Baldus, Dirk E. M. Geurts, Beat H. Meier · Solid State Nuclear Magnetic Resonance	Jun 1998	48
38	LC–MS Quantification of Oligonucleotides in Biological Matrices with Spe or Hybridization Extraction Luc Sips, Emmanuel Njumbe Ediage, Benno A. Ingelse et al. · Bioanalysis	Nov 2019	47
39	Return of the lysergamides. Part III: Analytical characterization of N6‐ethyl‐6‐norlysergic acid diethylamide (ETH‐LAD) and 1‐propionyl ETH‐LAD (1P–ETH‐LAD) Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal et al. · Drug Testing and Analysis Open access	25 Mar 2017	45
40	Plasmin‐activated doxorubicin prodrugs containing a spacer reduce tumor growth and angiogenesis without systemic toxicity Laetitia Devy, Franciscus M. H. de Groot, Silvia Blacher et al. · The FASEB Journal	20 Jan 2004	43
41	Quantitative structure–retention relationships in comparative studies of behavior of stationary phases under high-performance liquid chromatography and capillary electrochromatography conditions Jan Jiskra, Henk A. Claessens, C.A.M.G. Cramers et al. · Journal of Chromatography A	21 Oct 2002	42
42	Through-bond correlation of adenine H2 and H8 protons in unlabeled DNA fragments by HMBC spectroscopy Maria J. P. van Dongen, Sybren S. Wijmenga, Ramón Eritja et al. · Journal of Biomolecular NMR Open access	Sep 1996	41
43	Influence of growth stage on activities of polyhydroxyalkanoate (PHA) polymerase and PHA depolymerase in Pseudomonas putida U Qun Ren, Guy de Roo, Bernard Witholt et al. · BMC Microbiology Open access	2010	41
44	Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance Erik J. M. Toonen, Andreea-Manuela Mirea, Cees J. Tack et al. · Molecular Medicine Open access	2016	40
45	The Transition from a Neutral-pH Double Helix to a Low-pH Triple Helix Induces a Conformational Switch in the CCCG Tetraloop Closing a Watson-Crick Stem Maria J. P. van Dongen, Sybren S. Wijmenga, Gijsbert A. van der Marel et al. · Journal of Molecular Biology Open access	Nov 1996	34
46	Rapid screening of IgG quality attributes – effects on Fc receptor binding Karin Lubbers-Geuijen, Cindy Oppers‐Tiemissen, David F. Egging et al. · FEBS Open Bio Open access	10 Aug 2017	33
47	A Phase I Dose-Escalation and Bioequivalence Study of a Trastuzumab Biosimilar in Healthy Male Volunteers Liselijn A. B. Wisman, Eduard P. M. De Cock, Joannes A. A. Reijers et al. · Clinical Drug Investigation	7 Nov 2014	32
48	Polymorphism and Migratory Chiral Resolution of the Free Base of Venlafaxine. A Remarkable Topotactical Solid State Transition from a Racemate to a Racemic Conglomerate J.Th.H. Van Eupen, W.W.J. Elffrink, Rolf Keltjens et al. · Crystal Growth & Design	2008	30
49	Assignment Strategies and Analysis of Cross-Peak Patterns and Intensities in the Three-Dimensional Homonuclear TOCSY-NOESY of RNA Sybren S. Wijmenga, Hans A. Heus, Sebastiaan Werten et al. · Journal of Magnetic Resonance Series B	Feb 1994	28
50	Interactions of phenethylamine‐derived psychoactive substances of the 2C‐series with human monoamine oxidases Lea Wagmann, Simon D. Brandt, Alexander Stratford et al. · Drug Testing and Analysis Open access	6 Sep 2018	26

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.