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Most cited papers from The Francis Crick Institute

What are the most cited papers from The Francis Crick Institute?

The most cited paper from The Francis Crick Institute is "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018" (Lorenzo Galluzzi et al., 2018), with 6,760 citations. Next come "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)" (6,023) and "The nf-core framework for community-curated bioinformatics pipelines" (4,389).

Showing 50 of 60 papers. Every paper with more than 1,005 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Lorenzo Galluzzi et al. · Cell Death and Differentiation Open access169 authors 23 Jan 2018 6,760
2 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy Open access2,467 authors 2 Jan 2016 6,023
3 The nf-core framework for community-curated bioinformatics pipelines Philip Ewels, Alexander Peltzer, Sven Fillinger et al. · Nature Biotechnology Open access 13 Feb 2020 4,389
4 A framework for advancing our understanding of cancer-associated fibroblasts Erik A. Sahai et al. · Nature reviews. Cancer ReviewOpen access 24 Jan 2020 3,962
5 The repertoire of mutational signatures in human cancer Ludmil B. Alexandrov et al. · Nature Open access1,384 authors 5 Feb 2020 3,854
6 DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput Vadim Petrovich Demichev, Christoph B. Messner, Spyros I. Vernardis et al. · Nature Methods Open access 25 Nov 2019 3,652
7 Improved protein structure prediction using potentials from deep learning Andrew Senior, Richard Evans, John Jumper et al. · Nature Open access 15 Jan 2020 3,622
8 GISAID: Global initiative on sharing all influenza data – from vision to reality Yuelong Shu, John W. McCauley · Eurosurveillance Open access 30 Mar 2017 3,604
9 Neutrophil extracellular traps in immunity and disease Venizelos Papayannopoulos · Nature reviews. Immunology Review 9 Oct 2017 3,477
10 Virus interference. I. The interferon Alick Isaacs, Jean-Michel Lindenmann · Proceedings of the Royal Society B Biological Sciences 12 Sep 1957 3,446
11 Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature Open access1,324 authors 5 Feb 2020 3,360
12 The regulation of IL-10 production by immune cells Margarida Saraiva, Anne O’Garra · Nature reviews. Immunology ReviewOpen access 15 Feb 2010 3,198
13 Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Nicholas McGranahan et al. · Science Open access 3 Mar 2016 3,177
14 Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future Nicholas McGranahan, Charles Swanton · Cell Open access Feb 2017 3,002
15 Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic Timothy An-thy Chan, Mark M. Yarchoan, Elizabeth M. Jaffee et al. · Annals of Oncology Open access Nov 2018 2,932
16 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 Daniel J. Klionsky et al. · Autophagy Open access2,930 authors 2 Jan 2021 2,743
17 Classification of Intrinsically Disordered Regions and Proteins Robin van der Lee, Marija Buljan, Benjamin Lang et al. · Chemical Reviews ReviewOpen access 29 Apr 2014 2,336
18 Male development of chromosomally female mice transgenic for Sry Peter A. Koopman, John Gubbay, Nigel Vivian et al. · Nature May 1991 2,242
19 Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Christopher Abbosh et al. · Nature Open access104 authors 25 Apr 2017 1,978
20 Artificial intelligence in cancer imaging: Clinical challenges and applications Wenya Linda Bi, Ahmed Hosny, Matthew B. Schabath et al. · CA A Cancer Journal for Clinicians Open access 5 Feb 2019 1,886
21 NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control Jan P. Böttcher, Eduardo Bonavita, Probir Chakravarty et al. · Cell Open access Feb 2018 1,883
22 High burden and pervasive positive selection of somatic mutations in normal human skin Iñigo Martincorena, Amit Roshan, Moritz Gerstung et al. · Science Open access 22 May 2015 1,880
23 Universal Patterns of Selection in Cancer and Somatic Tissues Iñigo Martincorena, Keiran M. Raine, Moritz Gerstung et al. · Cell Open access 19 Oct 2017 1,706
24 A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes John Gubbay, Jérôme Collignon, Peter A. Koopman et al. · Nature Jul 1990 1,691
25 Molecular definitions of autophagy and related processes Lorenzo Galluzzi et al. · The EMBO Journal Open access 8 Jun 2017 1,670
26 High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction Georges Snounou, Suganya Viriyakosol, Xin Ping Zhu et al. · Molecular and Biochemical Parasitology Oct 1993 1,647
27 Chromosomal instability drives metastasis through a cytosolic DNA response Samuel F. W. Bakhoum et al. · Nature Open access 17 Jan 2018 1,621
28 The role of ROS in tumour development and progression Eric C. Cheung, Karen H. Vousden · Nature reviews. Cancer ReviewOpen access 31 Jan 2022 1,613
29 Autophagy in major human diseases Daniel J. Klionsky et al. · The EMBO Journal Open access 30 Aug 2021 1,608
30 Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission Hannah Peckham, Nina M. de Gruijter, Charles Raine et al. · Nature Communications Open access 9 Dec 2020 1,599
31 Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA M.C. Liu et al. · Annals of Oncology Open access159 authors 30 Mar 2020 1,567
32 Autophagy pathway: Cellular and molecular mechanisms Li Yu, Yang Chen, Sharon A. Tooze · Autophagy Open access 21 Sep 2017 1,531
33 Genetic mechanisms of critical illness in COVID-19 The GenOMICC Investigators et al. · Nature Open access 11 Dec 2020 1,515
34 The spectrum of latent tuberculosis: rethinking the biology and intervention strategies Clifton E. Barry, Helena I. Boshoff, Veronique Anne Dartois et al. · Nature Reviews Microbiology ReviewOpen access 26 Oct 2009 1,466
35 Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution Nicholas McGranahan et al. · Cell Open access223 authors 26 Oct 2017 1,361
36 deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution Rachel Rosenthal, Nicholas McGranahan, Javier Herrero et al. · Genome biology Open access 22 Feb 2016 1,358
37 Sequence requirements for nuclear location of simian virus 40 large-T antigen Daniel Kalderon, William David Richardson, Alexander F. Markham et al. · Nature 6 Sep 1984 1,331
38 TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines Dmitry Ershov, Minh-Son Phan, Joanna W. Pylvänäinen et al. · Nature Methods Open access 2 Jun 2022 1,329
39 High-throughput discovery of novel developmental phenotypes Mary E. Dickinson et al. · Nature Open access 13 Sep 2016 1,321
40 Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis Annika Warnatsch, Marianna Ioannou, Qian Wang et al. · Science Open access 16 Jul 2015 1,292
41 Content-aware image restoration: pushing the limits of fluorescence microscopy MARTIN G. WEIGERT et al. · Nature Methods Open access 19 Nov 2018 1,258
42 Role of the polycomb protein EED in the propagation of repressive histone marks Raphaël Margueron, Neil Justin, Katsuhito Ohno et al. · Nature Open access 20 Sep 2009 1,234
43 Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer Matthew David Hellmann et al. · Cancer Cell Open access 12 Apr 2018 1,197
44 Patterning the Vertebrate Neuraxis Andrew Lumsden, Robb K. Krumlauf · Science 15 Nov 1996 1,151
45 The evolutionary history of 2,658 cancers Moritz Gerstung et al. · Nature Open access1,441 authors 5 Feb 2020 1,149
46 Biology and therapeutic potential of interleukin-10 Margarida Saraiva, Paulo Rufino Paulino Vieira, Anne O’Garra · The Journal of Experimental Medicine Open access 14 Oct 2019 1,145
47 Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity Santiago Zelenay, Annemarthe G. van der Veen, Jan P. Böttcher et al. · Cell Open access Sep 2015 1,142
48 Mutational signatures associated with tobacco smoking in human cancer Ludmil B. Alexandrov, Young Seok Ju, Kerstin Haase et al. · Science Open access 3 Nov 2016 1,137
49 Mapping the human genetic architecture of COVID-19 COVID-19 Host Genetics Initiative et al. · Nature Open access3,896 authors 8 Jul 2021 1,130
50 Genetic compensation triggered by mutant mRNA degradation Mohamed A. El-Brolosy, Zacharias Kontarakis, Andrea Rossi et al. · Nature Open access 3 Apr 2019 1,126

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.