Most cited papers from The Wistar Institute

The Wistar Institute

What are the most cited papers from The Wistar Institute?

The most cited paper from The Wistar Institute is "The serial cultivation of human diploid cell strains" (Leonard Hayflick, Paul S. Moorhead, 1961), with 8,548 citations. Next come "Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease" (7,867) and "Understanding the tumor immune microenvironment (TIME) for effective therapy" (6,338).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 1,259 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The serial cultivation of human diploid cell strains Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research	Dec 1961	8,548
2	Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease Brent R. Stockwell et al. · Cell Open access	Oct 2017	7,867
3	Understanding the tumor immune microenvironment (TIME) for effective therapy Mikhail Binnewies, Edward W. Roberts, Kelly Kersten et al. · Nature Medicine Open access	20 Apr 2018	6,338
4	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy Open access2,467 authors	2 Jan 2016	6,023
5	The limited in vitro lifetime of human diploid cell strains Leonard Hayflick · Experimental Cell Research	Mar 1965	5,907
6	The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression Thomas Derrien et al. · Genome Research Open access	Sep 2012	5,308
7	Chromosome preparations of leukocytes cultured from human peripheral blood Paul S. Moorhead, Peter C. Nowell̀, William J. Mellman et al. · Experimental Cell Research	Sep 1960	4,247
8	Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling Kandice R. Levental, Hongmei Yu, Laura Kass et al. · Cell Open access	Nov 2009	4,155
9	Restoring function in exhausted CD8 T cells during chronic viral infection Daniel L. Barber, E. John Wherry, David Masopust et al. · Nature	28 Dec 2005	4,031
10	Biology of Natural Killer Cells Giorgio Trinchieri · Advances in immunology Book chapterOpen access	1989	2,934
11	Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response Gang Chen et al. · Nature Open access	Aug 2018	2,867
12	Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards Vincenzo Bronte, Sven Brandau, Shu‐Hsia Chen et al. · Nature Communications Open access	6 Jul 2016	2,806
13	The complex language of chromatin regulation during transcription Shelley L. Berger · Nature	May 2007	2,792
14	The Microprocessor complex mediates the genesis of microRNAs Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan et al. · Nature	Nov 2004	2,758
15	Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 Daniel J. Klionsky et al. · Autophagy Open access2,930 authors	2 Jan 2021	2,743
16	PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression Cheryl L. Day et al. · Nature	20 Aug 2006	2,694
17	Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity Giorgio Trinchieri · Annual Review of Immunology	Apr 1995	2,433
18	Genome sequence of the Brown Norway rat yields insights into mammalian evolution Richard A. Gibbs et al. · Nature Open access248 authors	Apr 2004	2,224
19	A promoter-level mammalian expression atlas Alistair R. R. Forrest et al. · Nature Open access261 authors	Mar 2014	2,221
20	Active genes are tri-methylated at K4 of histone H3 Helena Santos-Rosa, Robert Schneider, Andrew J. Bannister et al. · Nature	Sep 2002	2,191
21	Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response Catherine Scott Manno et al. · Nature Medicine	12 Feb 2006	2,172
22	Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection Shawn D. Blackburn, Haina Shin, W. Nicholas Haining et al. · Nature Immunology Open access	30 Nov 2008	2,110
23	TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy et al. · Nature Open access	22 Jun 2005	2,109
24	Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation Joe Swift, Irena Lambrova Ivanovska, Amnon Buxboim et al. · Science Open access	29 Aug 2013	2,080
25	Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen Barbara B. Knowles, Chin C. Howe, David P. Aden · Science	25 Jul 1980	2,050
26	The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment Vinit Kumar, Sima Patel, Evgenii N. Tcyganov et al. · Trends in Immunology ReviewOpen access	6 Feb 2016	2,037
27	Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions Vassilis G. Gorgoulis, Leandros-Vassilios F. Vassiliou, Panagiotis Karakaidos et al. · Nature	Apr 2005	2,018
28	Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints Jiřina Bártková et al. · Nature	Nov 2006	2,012
29	Integrins and other cell adhesion molecules Steven M Albelda, Clayton A. Buck · The FASEB Journal	Aug 1990	1,975
30	MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness R M Zinkernagel, Peter C. Doherty · Advances in immunology Book chapter	1979	1,946
31	Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity Filippo Veglia, Emilio Sanseviero, Dmitry I. Gabrilovich · Nature reviews. Immunology ReviewOpen access	Feb 2021	1,936
32	Myeloid-Derived Suppressor Cells Dmitry I. Gabrilovich · Cancer Immunology Research Open access	2017	1,936
33	An operational definition of epigenetics: Figure 1. Shelley L. Berger, Tony Kouzarides, Ramin Shiekhattar et al. · Genes & Development Open access	Apr 2009	1,878
34	Myeloid-derived suppressor cells coming of age Filippo Veglia, Michela Perego, Dmitry I. Gabrilovich · Nature Immunology Open access	4 Jan 2018	1,839
35	Involvement of the bcl -2 Gene in Human Follicular Lymphoma Yoshihide Tsujimoto, Jeffrey Cossman, Elaine S. Jaffe et al. · Science	21 Jun 1985	1,800
36	Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation Yoshihide Tsujimoto, L R Finger, Jorge J. Yunis et al. · Science	30 Nov 1984	1,793
37	Acetylation of Histones and Transcription-Related Factors David E. Sterner, Shelley L. Berger · Microbiology and Molecular Biology Reviews ReviewOpen access	Jun 2000	1,788
38	Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Riccardo Dalla‐Favera, Marco Bregni, J Erikson et al. · Proceedings of the National Academy of Sciences Open access	Dec 1982	1,785
39	Long Noncoding RNAs with Enhancer-like Function in Human Cells Ulf Andersson Ørom, Thomas Derrien, Malte Beringer et al. · Cell Open access	Oct 2010	1,779
40	Cancer as an evolutionary and ecological process Lauren M.F. Merlo, John W. Pepper, Brian J. Reid et al. · Nature reviews. Cancer Review	16 Nov 2006	1,760
41	Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide Martha S. Jordan, Alina C. Boesteanu, Amy J. Reed et al. · Nature Immunology	Apr 2001	1,665
42	Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing Richard I. Gregory, Thimmaiah P. Chendrimada, Neil S. Cooch et al. · Cell Open access	Nov 2005	1,576
43	Completion of mouse embryogenesis requires both the maternal and paternal genomes James M. McGrath, Davor Solter · Cell Open access	May 1984	1,575
44	Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. S E Macatonia, Nancy A. Hosken, Mark J. Litton et al. · The Journal of Immunology	May 1995	1,552
45	The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection Arlene H. Sharpe, E. John Wherry, Rafi Ahmed et al. · Nature Immunology	15 Feb 2007	1,532
46	Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy Guangping Gao, Mauricio R. Alvira, Lili Wang et al. · Proceedings of the National Academy of Sciences Open access	21 Aug 2002	1,532
47	A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade Livnat Jerby‐Arnon et al. · Cell Open access	Nov 2018	1,505
48	An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants Nobuhiro Suzuki, Tobun T. Cheung, Xiao-Dan Cai et al. · Science	27 May 1994	1,475
49	A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau Virginia M.‐Y. Lee, Brian Joseph Balin, László Ötvös et al. · Science	8 Feb 1991	1,422
50	Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. Annalisa D’Andrea, Miguel Aste-Amézaga, Nicholas M. Valiante et al. · The Journal of Experimental Medicine Open access	Sep 1993	1,406

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.