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Most cited papers from Trials Methodology Research Network

Trials Methodology Research Network

What are the most cited papers from Trials Methodology Research Network?

The most cited paper from Trials Methodology Research Network is "The COMET Handbook: version 1.0" (Paula Ruth Williamson, Douglas G. Altman, Heather Bagley et al., 2017), with 2,079 citations. Next come "Core Outcome Set–STAndards for Reporting: The COS-STAR Statement" (672) and "The yin and yang of nitric oxide in cancer progression" (376).

Showing 50 of 60 papers. Every paper with more than 56 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The COMET Handbook: version 1.0 Paula Ruth Williamson, Douglas G. Altman, Heather Bagley et al. · Trials Open access Jun 2017 2,079
2 Core Outcome Set–STAndards for Reporting: The COS-STAR Statement Jamie J Kirkham, Sarah L. Gorst, Douglas G. Altman et al. · PLoS Medicine Open access 18 Oct 2016 672
3 The yin and yang of nitric oxide in cancer progression Anthony Joseph Burke, Francis J Sullivan, Francis Joseph Giles et al. · Carcinogenesis Open access 25 Jan 2013 376
4 Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)? Shaun P. Treweek et al. · Trials Open access 23 Feb 2018 354
5 Efficacy and safety of COVID-19 vaccines Carolina Graña et al. · Cochrane Database of Systematic Reviews Open access 7 Dec 2022 323
6 Data Analysis and Synthesis Within a Realist Evaluation: Toward More Transparent Methodological Approaches Brynne Gilmore, Éilish McAuliffe, J. R. Power et al. · International Journal of Qualitative Methods Open access 2019 322
7 To Cross-Link or Not to Cross-Link? Cross-Linking Associated Foreign Body Response of Collagen-Based Devices Luis María Delgado, Yves Bayon, Abhay S. Pandit et al. · Tissue Engineering Part B Reviews Open access 17 Dec 2014 273
8 What Are the Effects of Teaching Evidence-Based Health Care (EBHC)? Overview of Systematic Reviews Taryn Young, Anke Rohwer, Jimmy A Volmink et al. · PLoS ONE ReviewOpen access 28 Jan 2014 266
9 Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study Francis Joseph Giles, Philipp D. le Coutre, Javier A. Pinilla-Ibarz et al. · Leukemia Open access 5 Jul 2012 252
10 Epidermal mucus, a major determinant in fish health: a review. Supriya Dash, Swagat Kumar Das, Juhi Samal et al. · PubMed Open access 2018 224
11 The trials methodological research agenda: results from a priority setting exercise Catrin Tudur Smith, Helen Hickey, Mike J Clarke et al. · Trials Open access 23 Jan 2014 223
12 Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis Louise Foley, James Larkin, Richard Lombard-Vance et al. · BMJ Open ReviewOpen access Sep 2021 209
13 Identifying trial recruitment uncertainties using a James Lind Alliance Priority Setting Partnership – the PRioRiTy (Prioritising Recruitment in Randomised Trials) study Patricia Healy et al. · Trials Open access 28 Feb 2018 200
14 Medication adherence among patients with apparent treatment-resistant hypertension Hannah Durand, Peter Hayes, Eimear C. Morrissey et al. · Journal of Hypertension 2 Aug 2017 197
15 Resilience, burnout and coping mechanisms in UK doctors: a cross-sectional study Nicola McKinley, Scott McCain, Liam J. Convie et al. · BMJ Open Open access 2020 196
16 Interleukin-6 blocking agents for treating COVID-19: a living systematic review Lina Ghosn et al. · Cochrane Database of Systematic Reviews ReviewOpen access 18 Mar 2021 185
17 Current trends in biologics delivery to restore intervertebral disc anabolism Gianluca Fontana, Eugene Yong-Shun See, Abhay S. Pandit · Advanced Drug Delivery Reviews Review 29 Aug 2014 162
18 Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomised controlled trial Peter J. Kelly et al. · The Lancet Open access 7 Jun 2024 154
19 The Consolidated Framework for Implementation Research (CFIR) User Guide: a five-step guide for conducting implementation research using the framework Caitlin Marie Reardon, Laura J. Damschroder, Laura Ellen Ashcraft et al. · Implementation Science Open access 16 Aug 2025 153
20 Core outcome sets for prevention and treatment of postpartum haemorrhage: an international Delphi consensus study Shireen Meher et al. · BJOG An International Journal of Obstetrics & Gynaecology 19 Jun 2018 129
21 Collagen: Finding a Solution for the Source S. Browne, Dimitrios I. Zeugolis, Abhay S. Pandit · Tissue Engineering Part A Open access 14 Dec 2012 127
22 Palliative care interventions in advanced dementia Edel Murphy, Katherine A. Froggatt, Sheelah Connolly et al. · Cochrane Database of Systematic Reviews Open access 2 Dec 2016 126
23 Barriers to the uptake of evidence from systematic reviews and meta-analyses: a systematic review of decision makers’ perceptions John Paul Wallace, Bosah Nwosu, Mike J Clarke · BMJ Open ReviewOpen access 2012 123
24 What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: the PRioRiTy II (Prioritising Retention in Randomised Trials) study Dan Brunsdon et al. · Trials Open access 15 Oct 2019 116
25 Developing complex interventions for nursing: a critical review of key guidelines Margarita Corry, Mike J Clarke, Alison While et al. · Journal of Clinical Nursing 29 Mar 2013 112
26 Core outcome sets in medical research Jamie J Kirkham, Paula Ruth Williamson · BMJ Medicine Open access Oct 2022 109
27 Maternity care during COVID-19: a qualitative evidence synthesis of women’s and maternity care providers’ views and experiences Sarah Jane Flaherty, Hannah Delaney, Karen Matvienko‐Sikar et al. · BMC Pregnancy and Childbirth Open access 26 May 2022 109
28 Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial Christopher Butler et al. · The Lancet Open access 12 Dec 2019 107
29 A General Method to Generate DNA Probes for Microorganisms Tom N. Barry, Richard Powell, Frank Gannon · Nature Biotechnology Mar 1990 107
30 A core outcome set for studies of gestational diabetes mellitus prevention and treatment Aoife Maria Egan et al. · Diabetologia Open access 20 Mar 2020 106
31 The COVID-NMA Project: Building an Evidence Ecosystem for the COVID-19 Pandemic Isabelle Boutron, Anna Chaimani, Joerg J Meerpohl et al. · Annals of Internal Medicine Open access 15 Sep 2020 102
32 Carotid Plaque Inflammation Imaged by 18 F-Fluorodeoxyglucose Positron Emission Tomography and Risk of Early Recurrent Stroke Peter J. Kelly et al. · Stroke Open access 6 Jun 2019 101
33 Observation of a rickettsia‐like organism in Atlantic salmon, Salmo salar L., in Ireland H. D. Rodger, E. M. Drinan · Journal of Fish Diseases Jul 1993 101
34 Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment Barbara Nußbaumer-Streit, Isolde Sommer, Candyce Hamel et al. · BMJ Evidence-Based Medicine Open access 19 Apr 2023 99
35 Hyaluronic acid decreases IL-6 and IL-8 secretion and permeability in an inflammatory model of interstitial cystitis Peadar Rooney, Akshay Kumar Srivastava, Luke Watson et al. · Acta Biomaterialia 5 Apr 2015 99
36 Readability and understandability of clinical research patient information leaflets and consent forms in Ireland and the UK: a retrospective quantitative analysis Lydia O’Sullivan, Prasanth Sukumar, Rachel Katherine Crowley et al. · BMJ Open Open access Sep 2020 97
37 Early Metformin in Gestational Diabetes Fidelma Dunne, Christine Newman, Alberto Alvarez‐Iglesias et al. · JAMA Open access 3 Oct 2023 91
38 “One‐step” Preparation of Thiol‐Ene Clickable PEG‐Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogel Yixiao Dong, Aram Omer Saeed, Waqar Ul Hassan et al. · Macromolecular Rapid Communications 5 Dec 2011 91
39 Biomaterial-Mediated Modification of the Local Inflammatory Environment S. Browne, Abhay S. Pandit · Frontiers in Bioengineering and Biotechnology Open access 15 May 2015 91
40 Development of a core outcome set for trials on induction of labour: an international multistakeholder Delphi study Francois Dos Santos, Stefania Drymiotou, Alba Antequera et al. · BJOG An International Journal of Obstetrics & Gynaecology Open access 7 Jul 2018 89
41 The Effectiveness of Disaster Risk Communication: A Systematic Review of Intervention Studies Declan Bradley, Marie McFarland, Mike J Clarke · PLoS Currents ReviewOpen access 2014 88
42 The impact of the PCR plateau phase on quantitative PCR Ciaran G. Morrison, Frank Gannon · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression Oct 1994 86
43 Use of core outcome sets was low in clinical trials published in major medical journals Karen Matvienko‐Sikar, KERRY N. L. AVERY, Jane M. Blazeby et al. · Journal of Clinical Epidemiology Open access 28 Oct 2021 85
44 RNA interference therapy via functionalized scaffolds Michael G. Monaghan, Abhay S. Pandit · Advanced Drug Delivery Reviews Review 18 Jan 2011 84
45 Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice Shoba Dawson et al. · Trials Open access 17 Aug 2022 82
46 Frequency and format of clinical trial results dissemination to patients: a survey of authors of trials indexed in PubMed Sara Schroter, Amy I Price, Mario Malički et al. · BMJ Open Open access Oct 2019 81
47 Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein Mohammad Abu-Rub, Kristen Lawrence Billiar, M.H. van Es et al. · Soft Matter Open access 2011 81
48 Comparative efficacy of exercise and anti-hypertensive pharmacological interventions in reducing blood pressure in people with hypertension: A network meta-analysis Chris Noone, Joy Leahy, Eimear C. Morrissey et al. · European Journal of Preventive Cardiology Open access 16 Oct 2019 70
49 Electric Field-Guided Neuron Migration:A Novel Approach in Neurogenesis Li Yao, Abhay S. Pandit, Sheng Yao et al. · Tissue Engineering Part B Reviews 30 Jan 2011 69
50 A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials Oriana Ciani et al. · EClinicalMedicine Open access 17 Oct 2023 68

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.