Most cited papers from Trudeau Institute

Trudeau Institute

What are the most cited papers from Trudeau Institute?

The most cited paper from Trudeau Institute is "Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development" (Gerritje J. W. van der Windt, Bart Everts, Chih‐Hao Chang et al., 2011), with 1,567 citations. Next come "IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge" (1,463) and "Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation" (1,262).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 321 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development Gerritje J. W. van der Windt, Bart Everts, Chih‐Hao Chang et al. · Immunity Open access	30 Dec 2011	1,567
2	IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge Shabaana Abdul Khader, Guy K Bell, John E. Pearl et al. · Nature Immunology	11 Mar 2007	1,463
3	Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation Connie M. Krawczyk, Thomas Holowka, Jie Sun et al. · Blood Open access	29 Mar 2010	1,262
4	Identification of nitric oxide synthase as a protective locus against tuberculosis John D. MacMicking, R J North, Ron LaCourse et al. · Proceedings of the National Academy of Sciences Open access	13 May 1997	1,188
5	Cell-Mediated Immune Responses in Tuberculosis Andrea May Cooper · Annual Review of Immunology ReviewOpen access	20 Mar 2009	1,179
6	TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation Bart Everts, Eyal Amiel, Stanley Ching‐Cheng Huang et al. · Nature Immunology Open access	23 Feb 2014	1,085
7	Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice Bao Lu, BARBARA J. RUTLEDGE, Long Gu et al. · The Journal of Experimental Medicine Open access	16 Feb 1998	1,029
8	Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4 Stephen T. Smiley, Jennifer A. King, Wayne W. Hancock · The Journal of Immunology Open access	Sep 2001	955
9	THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVO George B. Mackaness · The Journal of Experimental Medicine Open access	May 1969	933
10	IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases Michele W.L. Teng, Edward P. Bowman, Joshua J. McElwee et al. · Nature Medicine	29 Jun 2015	881
11	T CELL MEMORY Richard W Dutton, Linda M. Bradley, Susan L. Swain · Annual Review of Immunology Review	Apr 1998	835
12	Reciprocal regulation of polarized cytokine production by effector B and T cells David P. Harris, Laura Haynes, Peter C. Sayles et al. · Nature Immunology	Dec 2000	833
13	Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity Juan Moyron‐Quiroz, Javier Rangel‐Moreno, Kim L. Kusser et al. · Nature Medicine	15 Aug 2004	828
14	Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes Monika Julia Wolf et al. · Cancer Cell Open access	Oct 2014	695
15	I mmunity to T uberculosis R J North, Yu‐Jin Jung · Annual Review of Immunology Review	19 Mar 2004	690
16	Down-Regulation of the Antitumor Immune Response R J North · Advances in cancer research Book chapter	1985	684
17	THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE Philip B. Carter, Frank M. Collins · The Journal of Experimental Medicine Open access	May 1974	672
18	Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. R J North · The Journal of Experimental Medicine Open access	Apr 1982	649
19	The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne Mycobacterium tuberculosis Infection in Mice Tirsit Mogues, Mariam E. Goodrich, Lynn Ryan et al. · The Journal of Experimental Medicine Open access	29 Jan 2001	562
20	Cytokine-producing B lymphocytes — key regulators of immunity Frances E. Lund · Current Opinion in Immunology ReviewOpen access	17 Apr 2008	560
21	The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments Karsten Mahnke, Ming Guo, Sena Lee et al. · The Journal of Cell Biology Open access	30 Oct 2000	545
22	Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation André Ballesteros‐Tato, Beatriz León, Beth A. Graf et al. · Immunity Open access	29 Mar 2012	543
23	Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells Bart Everts, Eyal Amiel, Gerritje J. W. van der Windt et al. · Blood Open access	12 Jul 2012	538
24	Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus Eric J. Yager, Mushtaq Ahmed, Kathleen G. Lanzer et al. · The Journal of Experimental Medicine Open access	10 Mar 2008	497
25	Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis Javier Rangel‐Moreno, Louise Hartson, Carmen Navarro et al. · Journal of Clinical Investigation Open access	Dec 2006	497
26	IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available Shabaana Abdul Khader, John E. Pearl, Kaori Sakamoto et al. · The Journal of Immunology Open access	Jul 2005	476
27	Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis Xiaohong Zhang, Thomas B. Brunner, Laura Carter et al. · The Journal of Experimental Medicine Open access	19 May 1997	470
28	Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo Santiago Partida‐Sánchez, Debra A. Cockayne, Simon P. Monard et al. · Nature Medicine	Nov 2001	455
29	Migration, maintenance and recall of memory T cells in peripheral tissues David L. Woodland, Jacob E. Kohlmeier · Nature reviews. Immunology Review	25 Feb 2009	448
30	The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells Oliver Dienz, Sheri M. Eaton, Jeffrey P. Bond et al. · The Journal of Experimental Medicine Open access	12 Jan 2009	444
31	The development of inducible bronchus-associated lymphoid tissue depends on IL-17 Javier Rangel‐Moreno, Damian M. Carragher, María de la Luz García-Hernández et al. · Nature Immunology Open access	12 Jun 2011	444
32	Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis Cong‐Qiu Chu, Susan T. Wittmer, Dyana K. Dalton · The Journal of Experimental Medicine Open access	3 Jul 2000	422
33	Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations Satoshi Okada et al. · Science Open access	9 Jul 2015	418
34	Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections Robert Jeff Hogan, Edward J. Usherwood, Weimin Zhong et al. · The Journal of Immunology	Feb 2001	414
35	Class II-Independent Generation of CD4 Memory T Cells from Effectors Susan L. Swain, Hui Hu, Gail E. Huston · Science	12 Nov 1999	411
36	IL-4–producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells Irah L. King, Markus Mohrs · The Journal of Experimental Medicine Open access	20 Apr 2009	408
37	Evidence that tumor necrosis factor has an important role in antibacterial resistance. Edward A. Havell · The Journal of Immunology	Nov 1989	406
38	Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge Hiromasa Hamada, María de la Luz García-Hernández, Joyce B. Reome et al. · The Journal of Immunology Open access	Mar 2009	395
39	T follicular helper cells differentiate from Th2 cells in response to helminth antigens Arielle Glatman Zaretsky, Justin J. Taylor, Irah L. King et al. · The Journal of Experimental Medicine Open access	20 Apr 2009	387
40	Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue Lydia Lynch, Xavier Michelet, Sai Mei Zhang et al. · Nature Immunology Open access	Dec 2014	386
41	Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice Hui Zheng, Daniel S. Fletcher, Wiesław Kozak et al. · Immunity Open access	Jul 1995	368
42	Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. George L. Spitalny, Edward A. Havell · The Journal of Experimental Medicine Open access	May 1984	368
43	Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. Henry W. Murray, George L. Spitalny, C F Nathan · The Journal of Immunology	Mar 1985	358
44	Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo Creg J. Workman, Linda S. Cauley, In-Jeong Kim et al. · The Journal of Immunology	May 2004	353
45	CARBON MONOXIDE UPTAKE AND PULMONARY DIFFUSING CAPACITY IN NORMAL SUBJECTS AT REST AND DURING EXERCISE 1 Giles F. Filley, Donald Macintosh, George W. Wright · Journal of Clinical Investigation Open access	Dec 1954	352
46	The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis Andrea May Cooper, Shabaana Abdul Khader · Immunological Reviews ReviewOpen access	30 Oct 2008	351
47	IL-12p40: an inherently agonistic cytokine Andrea May Cooper, Shabaana Abdul Khader · Trends in Immunology Review	29 Nov 2006	347
48	INFLUENCE OF DOSE AND ROUTE OF ANTIGEN INJECTION ON THE IMMUNOLOGICAL INDUCTION OF T CELLS Philippe Henri Lagrange, George B. Mackaness, Thomas E. Miller · The Journal of Experimental Medicine Open access	Mar 1974	345
49	Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J. Wayne Conlan, R J North · The Journal of Experimental Medicine Open access	1994	345
50	Jump-starting the immune system: prime–boosting comes of age David L. Woodland · Trends in Immunology Review	4 Dec 2003	345

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.