Institution · Wihuri Research Institute
Most cited papers from Wihuri Research Institute
What are the most cited papers from Wihuri Research Institute?
The most cited paper from Wihuri Research Institute is "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society" (Børge Grønne Nordestgaard et al., 2013), with 2,797 citations. Next come "A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules" (2,233) and "A molecular atlas of cell types and zonation in the brain vasculature" (2,056).
Showing 50 of 60 papers. Every paper with more than 243 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society Børge Grønne Nordestgaard et al. · European Heart Journal | 15 Aug 2013 | 2,797 |
| 2 | A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules Aleksanteri Aspelund, Salli Antila, Steven T. Proulx et al. · The Journal of Experimental Medicine | 15 Jun 2015 | 2,233 |
| 3 | A molecular atlas of cell types and zonation in the brain vasculature Michael Vanlandewijck, Liqun He, Maarja Andaloussi Mäe et al. · Nature | 13 Feb 2018 | 2,056 |
| 4 | Lipoprotein(a) as a cardiovascular risk factor: current status Børge Grønne Nordestgaard, M. John Chapman, Kausik Kumar Ray et al. · European Heart Journal | 21 Oct 2010 | 1,824 |
| 5 | Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system Hellmut G. Augustin, Gou Young Koh, Gavin Thurston et al. · Nature Reviews Molecular Cell Biology | 23 Feb 2009 | 1,468 |
| 6 | Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins Marika J. Karkkainen, Paula Haiko, Kirsi Sainio et al. · Nature Immunology | 23 Nov 2003 | 1,435 |
| 7 | Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities Magnus Bäck, Arif Yurdagul, Ira A. Tabas et al. · Nature Reviews Cardiology | 7 Mar 2019 | 1,341 |
| 8 | Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management M. John Chapman, Henry N. Ginsberg, Pierre Amarenco et al. · European Heart Journal | 29 Apr 2011 | 1,241 |
| 9 | Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation Kristiina Rajamäki, Jani Lappalainen, Katariina Öörni et al. · PLoS ONE | 23 Jul 2010 | 1,040 |
| 10 | Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment Albert Wiegman et al. · European Heart Journal | 25 May 2015 | 898 |
| 11 | Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation Tuomas Tammela et al. · Nature | 25 Jun 2008 | 823 |
| 12 | VEGFs and receptors involved in angiogenesis versus lymphangiogenesis Marja K. Lohela, Maija Bry, Tuomas Tammela et al. · Current Opinion in Cell Biology | 22 Feb 2009 | 744 |
| 13 | Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage Michele M. Nava, Yekaterina A. Miroshnikova, Leah C. Biggs et al. · Cell | 16 Apr 2020 | 688 |
| 14 | Understanding the functions and relationships of the glymphatic system and meningeal lymphatics Antoine Louveau, Benjamin A. Plog, Salli Antila et al. · Journal of Clinical Investigation | 31 Aug 2017 | 659 |
| 15 | Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques Bernhard Schieffer, Elisabeth Schieffer, Denise Hilfiker‐Kleiner et al. · Circulation | 28 Mar 2000 | 647 |
| 16 | The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management Robert Alexander Hegele et al. · The Lancet Diabetes & Endocrinology | 22 Dec 2013 | 643 |
| 17 | Therapeutic targeting of the angiopoietin–TIE pathway Pipsa Saharinen, Lauri Eklund, Kari K. Alitalo · Nature Reviews Drug Discovery | 19 May 2017 | 628 |
| 18 | Infiltrates of Activated Mast Cells at the Site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction Petri T. Kovanen, Maija Kaartinen, Timo Paavonen · Circulation | Sep 1995 | 617 |
| 19 | Consensus guidelines for the use and interpretation of angiogenesis assays Patrycja Nowak‐Sliwinska et al. · Angiogenesis | 15 May 2018 | 607 |
| 20 | VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours Eric J. Song, Tianyang Mao, Huiping Dong et al. · Nature | 15 Jan 2020 | 551 |
| 21 | Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease Helena Gylling et al. · Atherosclerosis | 23 Nov 2013 | 527 |
| 22 | Development and plasticity of meningeal lymphatic vessels Salli Antila, Sinem Karaman, Harri J. Nurmi et al. · The Journal of Experimental Medicine | 15 Nov 2017 | 490 |
| 23 | Diet promotes sleep duration and quality Katri Peuhkuri, Nora Sihvola, Riitta Korpela · Nutrition Research | 25 Apr 2012 | 473 |
| 24 | RET tyrosine kinase signaling in development and cancer Elena Arighi, Maria Grazia Borrello, Hannu V. Sariola · Cytokine & Growth Factor Reviews | 28 Jun 2005 | 470 |
| 25 | Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts Pipsa Saharinen, Lauri Eklund, Juho Jalmari Miettinen et al. · Nature Cell Biology | 20 Apr 2008 | 460 |
| 26 | Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture. Maija Kaartinen, Antti Penttilä, Petri T. Kovanen · Circulation | Oct 1994 | 445 |
| 27 | Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL Tiia Hevonoja, Markku O. Pentikäinen, M. Hyvönen et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | Nov 2000 | 436 |
| 28 | Molecular Dynamics Simulations of Lipid Bilayers: Major Artifacts Due to Truncating Electrostatic Interactions M. Patra, M. Karttunen, M.T. Hyvönen et al. · Biophysical Journal | Jun 2003 | 423 |
| 29 | Tie receptors: new modulators of angiogenic and lymphangiogenic responses Nina Jones, Kristiina Iljin, Daniel Dumont et al. · Nature Reviews Molecular Cell Biology | Apr 2001 | 418 |
| 30 | TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages P Sarén, Howard G. Welgus, Petri T. Kovanen · The Journal of Immunology | Nov 1996 | 406 |
| 31 | Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer Biswajyoti Sahu, Marko Laakso, Kristian Ovaska et al. · The EMBO Journal | 13 Sep 2011 | 403 |
| 32 | Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells Jussi Taipale, Jouko Lohi, Juhani Saarinen et al. · Journal of Biological Chemistry | Mar 1995 | 398 |
| 33 | Molecular dynamics simulations of lipid bilayers : major artifacts due to truncating electrostatic interactions Patra, M, Karttunen, MEJ Mikko, Hyvönen, MT et al. · TU/e Research Portal | 2003 | 393 |
| 34 | Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome Kristiina Rajamäki, Tommy Nordström, Katariina Nurmi et al. · Journal of Biological Chemistry | 26 Mar 2013 | 361 |
| 35 | Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery Petri Laine, Maija Kaartinen, Antti Penttilä et al. · Circulation | 26 Jan 1999 | 343 |
| 36 | Vascular endothelial growth factor signaling in development and disease Sinem Karaman, Veli‐Matti Leppänen, Kari K. Alitalo · Development | 15 Jul 2018 | 342 |
| 37 | Circadian Clock Control by SUMOylation of BMAL1 Luca Cardone, Jun Hirayama, Francesca Giordano et al. · Science | 18 Aug 2005 | 331 |
| 38 | Lymphatic System in Cardiovascular Medicine Aleksanteri Aspelund, Marius R. Robciuc, Sinem Karaman et al. · Circulation Research | 4 Feb 2016 | 325 |
| 39 | Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway Katri Niemi, Laura Teirilä, Jani Lappalainen et al. · The Journal of Immunology | 21 Apr 2011 | 324 |
| 40 | Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. Juhani Saarinen, Nisse Kalkkinen, Howard G. Welgus et al. · Journal of Biological Chemistry | Jul 1994 | 319 |
| 41 | Tie1 controls angiopoietin function in vascular remodeling and inflammation Emilia A. Korhonen, Anita Lampinen, Hemant Giri et al. · Journal of Clinical Investigation | 21 Aug 2016 | 307 |
| 42 | Assessing the Nature of Lipid Raft Membranes Perttu S. Niemelä, O. H. Samuli Ollila, M. Hyvönen et al. · PLoS Computational Biology | 20 Feb 2007 | 298 |
| 43 | Lessons of Slicing Membranes: Interplay of Packing, Free Area, and Lateral Diffusion in Phospholipid/Cholesterol Bilayers Emma Falck, Michael Patra, Mikko Karttunen et al. · Biophysical Journal | Aug 2004 | 294 |
| 44 | Endothelial destabilization by angiopoietin-2 via integrin β1 activation Laura Hakanpää, Tuomas Sipilä, Veli‐Matti Leppänen et al. · Nature Communications | 30 Jan 2015 | 287 |
| 45 | Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice Ilze Bot, Saskia C.A. de Jager, Alma Zernecke et al. · Circulation | 30 Apr 2007 | 280 |
| 46 | Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation Ulla Wartiovaara, Petri Salvén, Hanna K. A. Mikkola et al. · Thrombosis and Haemostasis | 1998 | 278 |
| 47 | Statins for children with familial hypercholesterolemia Alpo F. Vuorio, Jaana Kuoppala, Petri T. Kovanen et al. · Cochrane Database of Systematic Reviews | 7 Jul 2017 | 265 |
| 48 | NOTUM from Apc-mutant cells biases clonal competition to initiate cancer Dustin James Flanagan et al. · Nature | 2 Jun 2021 | 263 |
| 49 | Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure Gábor Földes, Ferenc Horkay, István Szokodi et al. · Biochemical and Biophysical Research Communications | Aug 2003 | 261 |
| 50 | Nonvenous Origin of Dermal Lymphatic Vasculature Inés Martínez‐Corral, Maria Helena Ulvmar, Lukas Stanczuk et al. · Circulation Research | 3 Mar 2015 | 257 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.