Institution · Xenon Pharmaceuticals (Canada)

Most cited papers from Xenon Pharmaceuticals (Canada)

Xenon Pharmaceuticals (Canada)

What are the most cited papers from Xenon Pharmaceuticals (Canada)?

The most cited paper from Xenon Pharmaceuticals (Canada) is "Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency" (Angela R Brooks-Wilson et al., 1999), with 1,720 citations. Next come "Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia" (1,149) and "Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis" (985).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 59 papers. Every paper with more than 51 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency Angela R Brooks-Wilson et al. · Nature Genetics	Aug 1999	1,720
2	Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia Cathryn M. Lewis et al. · The American Journal of Human Genetics ReviewOpen access	Jul 2003	1,149
3	Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis George V. Papanikolaou et al. · Nature Genetics	30 Nov 2003	985
4	Mitoferrin is essential for erythroid iron assimilation George Shaw et al. · Nature	Mar 2006	633
5	Cystic fibrosis population carrier screening: 2004 revision of American College of Medical Genetics mutation panel Michael S. Watson, Garry R. Cutting, Robert J. Desnick et al. · Genetics in Medicine Open access	Sep 2004	480
6	Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy Johane M. Robitaille, Marcia L.E. MacDonald, Ajamete Kaykas et al. · Nature Genetics	12 Aug 2002	479
7	Loss‐of‐function mutations in the Na v 1.7 gene underlie congenital indifference to pain in multiple human populations Y. Paul Goldberg et al. · Clinical Genetics	26 Mar 2007	463
8	Hepcidin in iron overload disorders George V. Papanikolaou, Michalis Tzilianos, John I. Christakis et al. · Blood Open access	30 Jan 2005	447
9	Two Genes That Map to the STSL Locus Cause Sitosterolemia: Genomic Structure and Spectrum of Mutations Involving Sterolin-1 and Sterolin-2, Encoded by ABCG5 and ABCG8, Respectively Kangmo Lu, Mi-Hye Lee, E. Starr Hazard et al. · The American Journal of Human Genetics Open access	Aug 2001	359
10	Progress in Understanding and Treating SCN2A-Mediated Disorders Stephan Sanders et al. · Trends in Neurosciences ReviewOpen access	23 Apr 2018	358
11	Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux Michel Marcil, Angela R Brooks-Wilson, Susanne M. Clee et al. · The Lancet	Oct 1999	358
12	Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia Alan Attie, Ronald M. Krauss, Mark P. Gray-Keller et al. · Journal of Lipid Research Open access	29 Oct 2002	348
13	Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Shivani Ahuja et al. · Science	17 Dec 2015	335
14	Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes Susanne M. Clee, John J.P. Kastelein, Marjel van Dam et al. · Journal of Clinical Investigation Open access	15 Nov 2000	318
15	ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation Cheryl Lea Wellington, Elizabeth K.-Y. Walker, Agripina Suarez et al. · Laboratory Investigation Open access	Mar 2002	300
16	Common Genetic Variation in ABCA1 Is Associated With Altered Lipoprotein Levels and a Modified Risk for Coronary Artery Disease Susanne M. Clee, Aeilko Having Zwinderman, James C. Engert et al. · Circulation Open access	6 Mar 2001	292
17	Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis Alan Attie, John P. Kastelein, Michael R. Hayden · Journal of Lipid Research Open access	Nov 2001	286
18	Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase Kambiz N. Alavian, Hongmei Li, Leon P. Collis et al. · Nature Cell Biology Open access	18 Sep 2011	284
19	Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract Lei Bu, Yiping Jin, Yuefeng Shi et al. · Nature Genetics	24 Jun 2002	275
20	Increased ABCA1 activity protects against atherosclerosis Roshni Rebecca Singaraja, Catherine Fiévet, Graciela Rosa Castro et al. · Journal of Clinical Investigation Open access	Jul 2002	250
21	Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin Lan Lin, Y. Paul Goldberg, Tomas Ganz · Blood	6 Jul 2005	240
22	The Small Molecule GMX1778 Is a Potent Inhibitor of NAD + Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors Mark H. Watson et al. · Molecular and Cellular Biology Open access	24 Aug 2009	225
23	Inhibitory effects of cannabidiol on voltage-dependent sodium currents Mohammad‐Reza Ghovanloo, Noah Gregory Shuart, Janette Mezeyova et al. · Journal of Biological Chemistry Open access	17 Sep 2018	212
24	Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study Marjel van Dam, Eric de Groot, Susanne M. Clee et al. · The Lancet	2002	196
25	Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1 Roshni Rebecca Singaraja, Virginie Bocher, Erick R. James et al. · Journal of Biological Chemistry Open access	Sep 2001	194
26	Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain Sultan Chowdhury, Mikhail Ayratovich Chafeev, Shifeng Liu et al. · Bioorganic & Medicinal Chemistry Letters Open access	25 Apr 2011	159
27	Identification of a Novel Gene (HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates Ronald G.A. Lafrenière et al. · The American Journal of Human Genetics Open access	16 Apr 2004	158
28	Methyl-containing pharmaceuticals: Methylation in drug design Shaoyi Sun, Jianmin Fu · Bioorganic & Medicinal Chemistry Letters Open access	14 Sep 2018	155
29	Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker Yigal Paul Goldberg, Nicola Price, Rostam Namdari et al. · Pain	31 Oct 2011	150
30	A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease G. Kees Hovingh, Alison Brownlie, Radjesh J. Bisoendial et al. · Journal of the American College of Cardiology Open access	Oct 2004	130
31	Protein Kinase A Site-specific Phosphorylation Regulates ATP-binding Cassette A1 (ABCA1)-mediated Phospholipid Efflux Raymond H. See, Rosalinda A. Caday‐Malcolm, Roshni Rebecca Singaraja et al. · Journal of Biological Chemistry Open access	25 Oct 2002	128
32	ABCA1 Is Essential for Efficient Basolateral Cholesterol Efflux during the Absorption of Dietary Cholesterol in Chickens Jacob D. Mulligan, Matthew T. Flowers, Angie Tebon et al. · Journal of Biological Chemistry Open access	Apr 2003	127
33	Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency Michael R. Hayden, Susanne M. Clee, Angela R Brooks-Wilson et al. · Current Opinion in Lipidology	Apr 2000	123
34	The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1) Amanda Donovan · Blood	22 Aug 2002	107
35	Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1 Cheryl Lea Wellington, Liam R. Brunham, Steven Zhou et al. · Journal of Lipid Research Open access	23 Jul 2003	100
36	ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels KY Zwarts, Susanne M. Clee, AH Zwinderman et al. · Clinical Genetics Open access	Feb 2002	99
37	Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability Jianying Huang, Carlos G. Vanoye, Alison Cutts et al. · Journal of Clinical Investigation Open access	21 May 2017	98
38	Applications of amide isosteres in medicinal chemistry Shaoyi Sun, Qi Jia, Zaihui Zhang · Bioorganic & Medicinal Chemistry Letters Open access	22 Jul 2019	91
39	CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease Alicia Semaka, Chris Kay, Crystal N. Doty et al. · Journal of Medical Genetics	29 Jul 2013	91
40	Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action Amaury E. Fernández‐Montalván et al. · ACS Chemical Biology Open access	18 Oct 2017	90
41	Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease Zaihui Zhang, Natalie A. Dales, Michael D. Winther · Journal of Medicinal Chemistry	2 Dec 2013	90
42	Structure of the deep demersal fish fauna off Newfoundland PVR Snelgrove, R L Haedrich · Marine Ecology Progress Series Open access	1985	90
43	Genome‐wide scan for linkage to schizophrenia in a Spanish‐origin cohort from Costa Rica Lynn E. DeLisi, Andrea Mesén, Carlos Rodriguez et al. · American Journal of Medical Genetics	8 May 2002	87
44	GeneTests-GeneClinics: Genetic testing information for a growing audience Roberta A Pagon, Peter Z Tarczy-Hornoch, Patricia K. Baskin et al. · Human Mutation	10 Apr 2002	83
45	Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain Girish R. Bankar et al. · Cell Reports Open access	Sep 2018	80
46	NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats JP Johnson et al. · eLife Open access	24 Feb 2022	78
47	Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans Lr Brunham, Ian Tietjen, A.E. Bochem et al. · Clinical Genetics	11 Apr 2011	75
48	Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models Thilo Focken et al. · ACS Medicinal Chemistry Letters Open access	19 Jan 2016	73
49	Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN) Nicola Price, Rostam Namdari, Judith Neville et al. · Clinical Journal of Pain Open access	16 Jul 2016	69
50	Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity Mohammad‐Reza Ghovanloo, Koushik Choudhury, Tagore Sanketh Bandaru et al. · The Journal of General Physiology Open access	17 Mar 2021	66

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.