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Most cited papers in Biomedical Engineering

What are the most cited papers in Biomedical Engineering?

The most cited paper in Biomedical Engineering is "Comparison of simple potential functions for simulating liquid water" (William L. Jorgensen, Jayaraman Chandrasekhar, Jeffry D. Madura et al., 1983), with 42,894 citations. Next come "Equation of State Calculations by Fast Computing Machines" (37,517) and "Molecular dynamics with coupling to an external bath" (31,502).

Showing 50 of 100 papers. Every paper with more than 6,912 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Comparison of simple potential functions for simulating liquid water William L. Jorgensen, Jayaraman Chandrasekhar, Jeffry D. Madura et al. · The Journal of Chemical Physics 15 Jul 1983 42,894
2 Equation of State Calculations by Fast Computing Machines N. Metropolis, Arianna W. Rosenbluth, M. N. Rosenbluth et al. · The Journal of Chemical Physics Jun 1953 37,517
3 Molecular dynamics with coupling to an external bath Herman J. C. Berendsen, Johan P. M. Postma, Wilfred F. van Gunsteren et al. · The Journal of Chemical Physics Open access 15 Oct 1984 31,502
4 An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments W. C. Oliver, George M. Pharr · Journal of materials research/Pratt's guide to venture capital sources Jun 1992 27,030
5 Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents Vernon L. Singleton, Joseph A. Rossi · American Journal of Enology and Viticulture 1965 24,756
6 A smooth particle mesh Ewald method Ulrich Essmann, L. Perera, Max L. Berkowitz et al. · The Journal of Chemical Physics 15 Nov 1995 23,377
7 A new generation of Ca2+ indicators with greatly improved fluorescence properties. Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry Open access Mar 1985 21,798
8 Particle swarm optimization Riccardo Poli, James C. Kennedy, Tim Blackwell · Swarm Intelligence 31 Jul 2007 21,401
9 Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report) Matthias Thommes, Katsumi Kaneko, Alexander V. Neimark et al. · Pure and Applied Chemistry 2 Jul 2015 20,886
10 High resolution two-dimensional electrophoresis of proteins. Patrick H. O’Farrell · Journal of Biological Chemistry Open access May 1975 19,391
11 DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS* Baruch J. Davis · Annals of the New York Academy of Sciences Dec 1964 18,971
12 Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly Maarit Kangas, Raija Korpelainen, Irene Vikman et al. · Gerontology 13 Aug 2014 18,953
13 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology Aug 1981 18,543
14 ATHENA , ARTEMIS , HEPHAESTUS : data analysis for X-ray absorption spectroscopy using IFEFFIT Bruce Ravel, Matthew G. Newville · Journal of Synchrotron Radiation Open access 15 Jun 2005 16,947
15 The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments Stephen Andrew Bustin, Vladimı́r Beneš, Jeremy A. Garson et al. · Clinical Chemistry Open access 26 Feb 2009 16,583
16 NMRPipe: A multidimensional spectral processing system based on UNIX pipes Frank Delaglio, Stephan Grzesiek, Geerten W. Vuister et al. · Journal of Biomolecular NMR Nov 1995 16,465
17 Heart rate variability: Standards of measurement, physiological interpretation, and clinical use Marek Malik, J. Thomas Bigger, A. John Camm et al. · European Heart Journal Open access Mar 1996 15,375
18 A survey on deep learning in medical image analysis Geert J. S. Litjens, Thijs Kooi, Babak Ehteshami Bejnordi et al. · Medical Image Analysis Open access 26 Jul 2017 15,309
19 Nanostructured High‐Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes J.‐W. Yeh, Swe-Kai Chen, Sung‐Jan Lin et al. · Advanced Engineering Materials May 2004 15,287
20 Single-layer MoS2 transistors Branimir Radisavljevic, Aleksandra Rađenović, Jacopo Brivio et al. · Nature Nanotechnology Open access 30 Jan 2011 14,985
21 The Properties of Gases and Liquids Robert Cortas Reid, THOMAS K. SHERWOOD, Robert E. Street · Physics Today Apr 1959 14,172
22 Matrix Elasticity Directs Stem Cell Lineage Specification Adam Jeffrey Engler, Shamik Sen, Hugh Lee Sweeney et al. · Cell Open access Aug 2006 13,994
23 Graphene: Status and Prospects Andre K. Geim · Science Open access 18 Jun 2009 13,990
24 Optical Coherence Tomography David T. Huang, Eric A. Swanson, Charles P. Lin et al. · Science Open access 22 Nov 1991 13,894
25 Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide Sasha Stankovich, Dmitriy A. Dikin, Richard D. Piner et al. · Carbon 8 Mar 2007 13,883
26 A survey on sensor networks Ian Fuat Akyildiz, Weilian Su, Yogesh Sankarasubramaniam et al. · IEEE Communications Magazine Aug 2002 13,712
27 Antioxidant Determinations by the Use of a Stable Free Radical Marsden S. Blois · Nature Apr 1958 13,038
28 Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Laura C. Green, David A. Wagner, Joseph A. Glogowski et al. · Analytical Biochemistry Oct 1982 12,147
29 Improved Synthesis of Graphene Oxide Daniela C. Marcano, Dmitry V. Kosynkin, Jacob M. Berlin et al. · ACS Nano 22 Jul 2010 12,017
30 A training algorithm for optimal margin classifiers Bernhard E. Boser, Isabelle Guyon, Vladimir N. Vapnik Conference paper Jul 1992 11,724
31 Surface plasmon subwavelength optics William L. Barnes, Alain Dereux, Thomas W. Ebbesen · Nature Aug 2003 11,670
32 The chemistry of graphene oxide Daniel R. Dreyer, Sungjin Park, Christopher W. Bielawski et al. · Chemical Society Reviews Review 3 Nov 2009 11,601
33 Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa Hermann Schägger, Gebhard von Jagow · Analytical Biochemistry Nov 1987 11,542
34 Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils Xuesong Li, Weiwei Cai, Jinho An et al. · Science Open access 7 May 2009 11,244
35 The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment K. Lance Kelly, Eduardo A. Coronado, Lin Lin Zhao et al. · The Journal of Physical Chemistry B 21 Dec 2002 10,577
36 Orbital angular momentum of light and the transformation of Laguerre-Gaussian laser modes Leslie Allen, Marco W. Beijersbergen, R. J. C. Spreeuw et al. · Physical Review A Jun 1992 10,522
37 Large-scale pattern growth of graphene films for stretchable transparent electrodes Keun‐Soo Kim, Yüe Zhao, Houk Jang et al. · Nature 14 Jan 2009 10,482
38 Light Propagation with Phase Discontinuities: Generalized Laws of Reflection and Refraction Nanfang Yu, Patrice Genevet, Mikhail A. Kats et al. · Science Sep 2011 10,346
39 Carbon Nanotubes--the Route Toward Applications Ray H. Baughman, Anvar A. Zakhidov, Walt A. de Heer · Science 2 Aug 2002 10,268
40 An Introduction To Compressive Sampling Emmanuel J. Candès, Michael B. Wakin · IEEE Signal Processing Magazine Mar 2008 10,167
41 Phonons and related crystal properties from density-functional perturbation theory Stefano Baroni, Stefano de Gironcoli, Andrea Dal Corso et al. · Reviews of Modern Physics Open access 6 Jul 2001 10,098
42 Strong localization of photons in certain disordered dielectric superlattices Sajeev John · Physical Review Letters Open access 8 Jun 1987 10,049
43 PLS-regression: a basic tool of chemometrics Svante Wold, Michael Sjöstróm, Lennart Eriksson · Chemometrics and Intelligent Laboratory Systems Oct 2001 10,019
44 Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria Chris H. Polman, Stephen C. Reingold, Brenda Banwell et al. · Annals of Neurology Open access 11 Jan 2011 9,914
45 Signal Recovery From Random Measurements Via Orthogonal Matching Pursuit Joel A. Tropp, Anna C. Gilbert · IEEE Transactions on Information Theory Dec 2007 9,832
46 New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute 4 Jul 1990 9,830
47 Tissue Engineering Róbert Langer, Joseph P. Vacanti · Science 14 May 1993 9,666
48 The origins and the future of microfluidics George M. Whitesides · Nature Jul 2006 9,641
49 How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki Takadama · Biomaterials Feb 2006 9,606
50 nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation Fabian Isensee, Paul F. Jaeger, Simon A. A. Kohl et al. · Nature Methods Open access 7 Dec 2020 9,588

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.