Subfield · Immunology
Most cited papers in Immunology
What are the most cited papers in Immunology?
The most cited paper in Immunology is "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China" (Chaolin Huang et al., 2020), with 52,028 citations. Next come "PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer" (30,915) and "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)" (29,012).
Showing 50 of 100 papers. Every paper with more than 5,545 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Chaolin Huang et al. · The Lancet | 24 Jan 2020 | 52,028 |
| 2 | PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer Andreas Daniel Hartkopf, Florin‐Andrei Taran, Markus Wallwiener et al. · Breast Care | 2016 | 30,915 |
| 3 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA | 22 Feb 2016 | 29,012 |
| 4 | Atherosclerosis — An Inflammatory Disease Russell Ross · New England Journal of Medicine | 14 Jan 1999 | 21,815 |
| 5 | Integrated analysis of multimodal single-cell data Yuhan Hao et al. · Cell | 31 May 2021 | 16,879 |
| 6 | Improved Survival with Ipilimumab in Patients with Metastatic Melanoma Frank Stephen Hodi et al. · New England Journal of Medicine | 5 Jun 2010 | 15,337 |
| 7 | Inflammation and cancer Lisa M. Coussens, Zena Werb · Nature | Dec 2002 | 15,251 |
| 8 | Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al. · Molecular Cell | May 2010 | 14,980 |
| 9 | The 1982 revised criteria for the classification of systemic lupus erythematosus Eng M. Tan, Alan S. Cohen, James F. Fries et al. · Arthritis & Rheumatism | Nov 1982 | 14,664 |
| 10 | Dendritic cells and the control of immunity Jacques Banchereau, Ralph M. Steinman · Nature | Mar 1998 | 14,440 |
| 11 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid K. Burton · Biochemical Journal | Feb 1956 | 14,144 |
| 12 | The blockade of immune checkpoints in cancer immunotherapy Drew M. Pardoll · Nature reviews. Cancer | 22 Mar 2012 | 14,033 |
| 13 | Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer Suzanne Louise Topalian et al. · New England Journal of Medicine | 14 Jun 2012 | 12,842 |
| 14 | Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Roujian Lu et al. · The Lancet | 30 Jan 2020 | 12,621 |
| 15 | Pathogen Recognition and Innate Immunity Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi · Cell | Feb 2006 | 12,064 |
| 16 | Cancer-related inflammation Alberto Mantovani, Paola Allavena, Antonio Sica et al. · Nature | Jul 2008 | 11,477 |
| 17 | Immunity, Inflammation, and Cancer Sergei I. Grivennikov, Florian R. Greten, Michael Karin · Cell | Mar 2010 | 10,888 |
| 18 | Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry | 2017 | 10,709 |
| 19 | The pathogenesis of atherosclerosis: a perspective for the 1990s Russell Ross · Nature | Apr 1993 | 10,703 |
| 20 | Prospective identification of tumorigenic breast cancer cells Muhammad Al‐Hajj, Max S. Wicha, Adalberto Benito‐Hernández et al. · Proceedings of the National Academy of Sciences | 10 Mar 2003 | 10,455 |
| 21 | Neutrophil Extracellular Traps Kill Bacteria Volker Brinkmann, Ulrike Reichard, Christian Goosmann et al. · Science | 4 Mar 2004 | 10,383 |
| 22 | COVID-19: consider cytokine storm syndromes and immunosuppression Puja Mehta, Daniel Francis McAuley, Michael Brown et al. · The Lancet | Mar 2020 | 10,244 |
| 23 | Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer H. Borghaei et al. · New England Journal of Medicine | 27 Sep 2015 | 9,557 |
| 24 | Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease Paul M. Ridker et al. · New England Journal of Medicine | 27 Aug 2017 | 9,517 |
| 25 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Taro Kawai, Shizuo Akira · Nature Immunology | 20 Apr 2010 | 9,343 |
| 26 | Exploring the full spectrum of macrophage activation David M. Mosser, Justin P. Edwards · Nature reviews. Immunology | 25 Nov 2008 | 9,246 |
| 27 | Pattern Recognition Receptors and Inflammation Osamu Takeuchi, Shizuo Akira · Cell | Mar 2010 | 8,914 |
| 28 | Inflammation, Atherosclerosis, and Coronary Artery Disease Göran K. Hansson · New England Journal of Medicine | 20 Apr 2005 | 8,822 |
| 29 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Derek C. Angus, Walter T. Linde‐Zwirble, Jeffrey R. Lidicker et al. · Critical Care Medicine | Jul 2001 | 8,644 |
| 30 | NF-κB signaling in inflammation Ting Liu, Lingyun Zhang, Donghyun Joo et al. · Signal Transduction and Targeted Therapy | 14 Jul 2017 | 8,517 |
| 31 | Antimicrobial peptides of multicellular organisms MICHAEL A. ZASLOFF · Nature | 2002 | 8,479 |
| 32 | Innate Immune Recognition Charles A. Janeway, Ruslan M. Medzhitov · Annual Review of Immunology | Apr 2002 | 8,439 |
| 33 | Obesity is associated with macrophage accumulation in adipose tissue Stuart Phillip Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation | 15 Dec 2003 | 8,398 |
| 34 | Neurotoxic reactive astrocytes are induced by activated microglia Shane A. Liddelow et al. · Nature | 2017 | 8,364 |
| 35 | Toll-like receptor signalling Shizuo Akira, Kiyoshi Takeda · Nature reviews. Immunology | 30 Jun 2004 | 8,340 |
| 36 | Inflammation in atherosclerosis Peter Libby · Nature | Dec 2002 | 8,286 |
| 37 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma James Larkin et al. · New England Journal of Medicine | 31 May 2015 | 8,266 |
| 38 | Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science | 13 Feb 2003 | 8,213 |
| 39 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study Kristina E. Rudd et al. · The Lancet | 2020 | 8,189 |
| 40 | Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer Julie Renee Brahmer et al. · New England Journal of Medicine | 14 Jun 2012 | 8,100 |
| 41 | Glutamate neurotoxicity and diseases of the nervous system Dennis W. Choi · Neuron | Oct 1988 | 8,019 |
| 42 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Jason D. Fontenot, Marc A. Gavin, Alexander Yu Rudensky · Nature Immunology | 3 Mar 2003 | 7,778 |
| 43 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Timothy R. Mosmann, Holly M. Cherwinski, M W Bond et al. · The Journal of Immunology | Apr 1986 | 7,553 |
| 44 | The biochemistry of apoptosis Michael Otmar Hengartner · Nature | Oct 2000 | 7,357 |
| 45 | Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position Jason Daniel Buenrostro, Paul G. Giresi, Lisa C. Zaba et al. · Nature Methods | 6 Oct 2013 | 7,255 |
| 46 | Cell Death: The Significance of Apoptosis A H Wyllie, John F. R. Kerr, Richard A. Currie · International review of cytology | 1980 | 7,243 |
| 47 | Oncology Meets Immunology: The Cancer-Immunity Cycle Daniel S. Chen, Ira Mellman · Immunity | Jul 2013 | 7,122 |
| 48 | Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J P Mizgerd, H Kubo, G J Kutkoski et al. · PubMed | 20 Oct 1997 | 7,117 |
| 49 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell Dominique A. Bonnet, John Edgar Dick · Nature Medicine | Jul 1997 | 7,031 |
| 50 | Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature | 30 Apr 2006 | 7,030 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.