Most cited papers in Adenosine and Purinergic Signaling
What are the most cited papers in Adenosine and Purinergic Signaling?
The most cited paper in Adenosine and Purinergic Signaling is "ATP mediates rapid microglial response to local brain injury in vivo" (Dimitrios Davalos, Jaime Grutzendler, Guang Yang et al., 2005), with 4,040 citations. Next come "Receptors for Purines and Pyrimidines" (3,980) and "Immunogenic Cell Death in Cancer Therapy" (3,313).
Showing 50 of 100 papers. Every paper with more than 938 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | ATP mediates rapid microglial response to local brain injury in vivo Dimitrios Davalos, Jaime Grutzendler, Guang Yang et al. · Nature Neuroscience | 15 May 2005 | 4,040 |
| 2 | Receptors for Purines and Pyrimidines Geoffrey Burnstock, Alexei Verkhratsky | 2012 | 3,980 |
| 3 | Immunogenic Cell Death in Cancer Therapy Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp et al. · Annual Review of Immunology | 16 Nov 2012 | 3,313 |
| 4 | Immunogenic cell death and DAMPs in cancer therapy Dmitri V. Krysko, Abhishek Dinkarnath Garg, Agnieszka Kaczmarek et al. · Nature reviews. Cancer | 15 Nov 2012 | 3,231 |
| 5 | Molecular Physiology of P2X Receptors Richard Alan North · Physiological Reviews | 10 Jan 2002 | 2,936 |
| 6 | Activation and regulation of the inflammasomes Eicke Latz, Tsan Sam Xiao, Andrea Stutz · Nature reviews. Immunology | 24 May 2013 | 2,928 |
| 7 | NAD(P)H Oxidase Kathy K. Griendling, Dan C. Sorescu, Masuko Ushio‐Fukai · Circulation Research | 17 Mar 2000 | 2,891 |
| 8 | Thioredoxin-interacting protein links oxidative stress to inflammasome activation Rongbin Zhou, Aubry Tardivel, Bernard Thorens et al. · Nature Immunology | 20 Dec 2009 | 2,719 |
| 9 | Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor Christopher N. Parkhurst, Guang Yang, Ipe Ninan et al. · Cell | Dec 2013 | 2,718 |
| 10 | International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson et al. · Pharmacological Reviews | Dec 2001 | 2,575 |
| 11 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression Silvia Deaglio, Karen M. Dwyer, Wenda Gao et al. · The Journal of Experimental Medicine | 14 May 2007 | 2,457 |
| 12 | Mediators of endoplasmic reticulum stress‐induced apoptosis Éva Szegezdi, Susan E. Logue, Adrienne M. Gorman et al. · EMBO Reports | Sep 2006 | 2,374 |
| 13 | Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration Liya Qin, Xuefei Wu, Michelle L. Block et al. · Glia | 3 Jan 2007 | 2,191 |
| 14 | Radioimmunoassay for Cyclic Nucleotides Alton L. Steiner, Charles W. Parker, DAVID M. KIPNIS · Journal of Biological Chemistry | Feb 1972 | 2,032 |
| 15 | Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production Tatsuya Saitoh, Naonobu Fujita, Myoung Ho Jang et al. · Nature | 5 Oct 2008 | 2,016 |
| 16 | Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis Marcel Leist, Barbara Single, Anna Federica Castoldi et al. · The Journal of Experimental Medicine | 21 Apr 1997 | 1,883 |
| 17 | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors François Ghiringhelli et al. · Nature Medicine | 20 Sep 2009 | 1,881 |
| 18 | Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure James I. Morgan, Donna Cohén, James L. Hempstead et al. · Science | 10 Jul 1987 | 1,817 |
| 19 | The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist Veli‐Pekka Jaakola, Mark T. Griffith, Michael A. Hanson et al. · Science | 2 Oct 2008 | 1,789 |
| 20 | Extracellular ATP: effects, sources and fate John L. Gordon · Biochemical Journal | 15 Jan 1986 | 1,665 |
| 21 | The Role and Regulation of Adenosine in the Central Nervous System Thomas V. Dunwiddie, Susan A. Masino · Annual Review of Neuroscience | Mar 2001 | 1,646 |
| 22 | Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance Michael Rusty Elliott, Faraaz B. Chekeni, Paul C. Trampont et al. · Nature | Sep 2009 | 1,643 |
| 23 | Complement System Part I – Molecular Mechanisms of Activation and Regulation Nicolas S. Merle, S. Church, Véronique Frémeaux‐Bacchi et al. · Frontiers in Immunology | 2 Jun 2015 | 1,618 |
| 24 | Physiology and Pathophysiology of Purinergic Neurotransmission Geoffrey Burnstock · Physiological Reviews | Apr 2007 | 1,595 |
| 25 | Nomenclature and classification of purinoceptors. Bertil B. Fredholm, Maria P. Abbracchio, Geoffrey Burnstock et al. · Pharmacological Reviews | Jun 1994 | 1,595 |
| 26 | The P2Y12 receptor regulates microglial activation by extracellular nucleotides Sharon E Haynes, Gunther Hollopeter, Guang Yang et al. · Nature Neuroscience | 19 Nov 2006 | 1,579 |
| 27 | P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Makoto Tsuda, Yukari Shigemoto‐Mogami, Schuichi Koizumi et al. · Nature | Aug 2003 | 1,567 |
| 28 | The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress Yoshiharu Kawaguchi, Jeffrey J. Kovacs, Adam C. McLaurin et al. · Cell | Dec 2003 | 1,545 |
| 29 | A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate BARRY L. BROWN, J. D. M. Albano, Roger P Ekins et al. · Biochemical Journal | Feb 1971 | 1,542 |
| 30 | Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor Pablo Pelegrı́n, Annmarie Surprenant · The EMBO Journal | 12 Oct 2006 | 1,456 |
| 31 | Mycophenolate mofetil and its mechanisms of action ANTHONY C. ALLISON, Elsie M. Eugui · Immunopharmacology | May 2000 | 1,438 |
| 32 | Identification of the platelet ADP receptor targeted by antithrombotic drugs Gunther Hollopeter, Hans‐Michael Jantzen, D Vincent et al. · Nature | 2001 | 1,433 |
| 33 | Adenosine receptors as therapeutic targets Kenneth A. Jacobson, Zhan‐Guo Gao · Nature Reviews Drug Discovery | Mar 2006 | 1,430 |
| 34 | Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities Go Saito, Joel A. Swanson, Kyung‐Dall Lee · Advanced Drug Delivery Reviews | Feb 2003 | 1,410 |
| 35 | Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study Louise Arseneault, Mary D Cannon, Richie Poulton et al. · BMJ | 21 Nov 2002 | 1,410 |
| 36 | Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy Lukas Franz Mager, Regula Burkhard, Nicola Pett et al. · Science | 13 Aug 2020 | 1,409 |
| 37 | Regulation of uric acid metabolism and excretion Jessica Maiuolo, Francesca Oppedisano, Santo Gratteri et al. · International Journal of Cardiology | 14 Aug 2015 | 1,404 |
| 38 | ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS Dietrich van Calker, Margarete Müller, Bernd Hamprecht · Journal of Neurochemistry | Nov 1979 | 1,373 |
| 39 | Is there a basis for distinguishing two types of P2-purinoceptor? Geoffrey Burnstock, Charles J. Kennedy · General Pharmacology The Vascular System | 1985 | 1,370 |
| 40 | A proton-gated cation channel involved in acid-sensing Rainer Waldmann, Guy Champigny, Frédéric Bassilana et al. · Nature | Mar 1997 | 1,365 |
| 41 | Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice Mickaël Michaud, Isabelle Martins, Abdul Qader Sukkurwala et al. · Science | 15 Dec 2011 | 1,361 |
| 42 | Astrocyte Control of Synaptic Transmission and Neurovascular Coupling Philip G. Haydon, Giorgio Carmignoto · Physiological Reviews | 30 Jun 2006 | 1,334 |
| 43 | Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion Lydia Aguilar‐Bryan, Colin G. Nichols, Sérgio Wechsler et al. · Science | 21 Apr 1995 | 1,331 |
| 44 | Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage Akio Ohta, Michail V. Sitkovsky · Nature | Dec 2001 | 1,330 |
| 45 | The autophagosome: origins unknown, biogenesis complex Christopher A. Lamb, Tamotsu Yoshimori, Sharon A. Tooze · Nature Reviews Molecular Cell Biology | 8 Nov 2013 | 1,328 |
| 46 | International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update Bertil B. Fredholm, Adriaan P. IJzerman, Kenneth A. Jacobson et al. · Pharmacological Reviews | 15 Feb 2011 | 1,316 |
| 47 | Astrocytic Purinergic Signaling Coordinates Synaptic Networks Olivier Pascual, Kristen B. Casper, Cathryn Kubera et al. · Science | 6 Oct 2005 | 1,297 |
| 48 | The P2X7 Receptor in Infection and Inflammation Francesco Di Virgilio, Diego Dal Ben, Alba Clara Sarti et al. · Immunity | Jul 2017 | 1,294 |
| 49 | ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation Tatsuo Hashimoto et al. · Nature | 24 Jul 2012 | 1,291 |
| 50 | International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy Maria P. Abbracchio, Geoffrey Burnstock, Jean‐Marie Boeynaems et al. · Pharmacological Reviews | Sep 2006 | 1,284 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.