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Topic · Physiology

Adenosine and Purinergic Signaling

Adenosine and Purinergic Signaling is a research topic within Physiology. Science Explorer counts 28k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.

  • Purinergic Signalling
  • Adenosine Receptors
  • P2X Receptors
  • Nucleotide Signalling
  • Immune Suppression
  • Inflammation
  • Neuroprotection
  • Extracellular ATP
  • Tumor Microenvironment
  • Therapeutic Targets
Research works
28k
fractional, since 1950
In the world top 10%
2.8k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+7%
the tick is no change
Largest producer
China
39% of the 10 largest, 2022-now
Adenosine and Purinergic Signaling

Which countries lead Adenosine and Purinergic Signaling research?

By volume, China and the United States publish the most (1.2k and 805 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.2k works
  2. 2 United States 805 works
  3. 3 Germany 170 works
  4. 4 Japan 165 works
  5. 5 India 133 works
  6. 6 Italy 132 works
  7. 7 United Kingdom 121 works
  8. 8 Brazil 110 works
  9. 9 South Korea 91 works
  10. 10 France 82 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 39.0%United States: 27.2%Germany: 5.7%Japan: 5.6%6 others listed: 22.6%39%largest
China1,155 · 39.0%United States805 · 27.2%Germany170 · 5.7%Japan165 · 5.6%6 others listed670 · 22.6%

Shares of the rows listed above, not of the whole node.

Which institutions lead Adenosine and Purinergic Signaling research?

By volume in 2022-now, National Institutes of Health publishes the most Adenosine and Purinergic Signaling research, followed by Harvard University and Sun Yat-sen University.

By volume, 2022-now

  1. 1 National Institutes of HealthUnited States 32 works
  2. 2 Harvard UniversityUnited States 32 works
  3. 3 Sun Yat-sen UniversityChina 30 works
  4. 4 Shanghai Jiao Tong UniversityChina 27 works
  5. 5 Chinese Academy of SciencesChina 26 works
  6. 6 Fudan UniversityChina 25 works
  7. 7 Sichuan UniversityChina 24 works
  8. 8 Nanchang UniversityChina 22 works
  9. 9 Nanjing Medical UniversityChina 21 works
  10. 10 Centre National de la Recherche ScientifiqueFrance 20 works

Who are the leading researchers in Adenosine and Purinergic Signaling?

The most-cited researchers publishing on Adenosine and Purinergic Signaling include Guido Kroemer, Shizuo Akira and Jun Wang.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Shizuo Akira Japan 342k citations
  3. 3 Jun Wang China 340k citations
  4. 4 Giuseppe Remuzzi Italy 328k citations
  5. 5 Luigi Ferrucci United States 281k citations
  6. 6 Matthew M. Meyerson United States 280k citations
  7. 7 Michael Karin United States 276k citations
  8. 8 Hagop M. Kantarjian United States 273k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Adenosine and Purinergic Signaling?

The most cited paper in Adenosine and Purinergic Signaling is "ATP mediates rapid microglial response to local brain injury in vivo" (Dimitrios Davalos, Jaime Grutzendler, Guang Yang et al., 2005), with 4,040 citations. Next come "Receptors for Purines and Pyrimidines" (3,980) and "Immunogenic Cell Death in Cancer Therapy" (3,313).

Most cited papers
#PaperReleasedCitations
1 ATP mediates rapid microglial response to local brain injury in vivo Dimitrios Davalos, Jaime Grutzendler, Guang Yang et al. · Nature Neuroscience 15 May 2005 4,040
2 Receptors for Purines and Pyrimidines Geoffrey Burnstock, Alexei Verkhratsky Book chapter 2012 3,980
3 Immunogenic Cell Death in Cancer Therapy Guido Kroemer, Lorenzo Galluzzi, Oliver Kepp et al. · Annual Review of Immunology Review 16 Nov 2012 3,313
4 Immunogenic cell death and DAMPs in cancer therapy Dmitri V. Krysko, Abhishek Dinkarnath Garg, Agnieszka Kaczmarek et al. · Nature reviews. Cancer ReviewOpen access 15 Nov 2012 3,231
5 Molecular Physiology of P2X Receptors Richard Alan North · Physiological Reviews Review 10 Jan 2002 2,936
All 100 most cited papers, with filters and sorting

Where is Adenosine and Purinergic Signaling research done?

The largest centres of Adenosine and Purinergic Signaling research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda and Nanchang.

Largest cities, 2022-now

  1. 1 BeijingChina 109 works
  2. 2 ShanghaiChina 101 works
  3. 3 GuangzhouChina 80 works
  4. 4 NanjingChina 66 works
  5. 5 ChengduChina 51 works
  6. 6 WuhanChina 50 works
  7. 7 TokyoJapan 42 works
  8. 8 SeoulSouth Korea 41 works
  9. 9 HangzhouChina 37 works
  10. 10 ParisFrance 36 works

Where it is the local speciality

  1. BethesdaUS · 30.9 works6.8×
  2. NanchangCN · 30.4 works4.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Adenosine and Purinergic Signaling than the world average.

See Adenosine and Purinergic Signaling on the map

Where is the best place to study Adenosine and Purinergic Signaling?

Among universities, judged by research, Sun Yat-sen University, Fudan University and Harvard University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 19.45%fractional works in this field (log) →share of work in the world top 10% →University of FerraraFudan UniversitySun Yat-sen UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 74.918.3%4.3×30 +62.8%
2Fudan UniversityChina 74.518.5%4.8×25 +50.9%
3Harvard UniversityUnited States 72.416.9%3.0×32 -16.0%
4University of FerraraItaly 66.322.6%21.6×13 -42.0%
5Oregon Health & Science UniversityUnited States 65.324.0%9.6×11 +209.9%
6Southern Medical UniversityChina 64.718.6%8.4×17 +138.8%
7Sichuan UniversityChina 62.816.8%3.2×24 +93.0%
8China Pharmaceutical UniversityChina 62.720.7%19.3×14 +96.5%
9Nanjing Medical UniversityChina 60.916.6%7.0×21 +103.3%
10Nanjing University of Chinese MedicineChina 59.521.5%11.0×9 +100.8%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Adenosine and Purinergic Signaling, country by country

Is Adenosine and Purinergic Signaling research growing?

Output in 2022-2025 was 7% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Adenosine and Purinergic Signaling.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Adenosine and Purinergic Signaling as a percentage of every work published that year, 0.017% in 2024.

still counting0.020%0.040%0.060%Adenosine and Purinergic Signaling0.016% in 202519801990200020102020

Fractional works of Adenosine and Purinergic Signaling over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Adenosine and Purinergic Signaling10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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