Topic · Adipose Tissue and Metabolism
Most cited papers in Adipose Tissue and Metabolism
What are the most cited papers in Adipose Tissue and Metabolism?
The most cited paper in Adipose Tissue and Metabolism is "Positional cloning of the mouse obese gene and its human homologue" (Yiying Zhang, Ricardo Proenca, Margherita Maffei et al., 1994), with 13,483 citations. Next come "Inflammation and metabolic disorders" (9,214) and "Biochemistry and molecular cell biology of diabetic complications" (9,153).
Showing 50 of 98 papers. Every paper with more than 2,559 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Positional cloning of the mouse obese gene and its human homologue Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature | Dec 1994 | 13,483 |
| 2 | Inflammation and metabolic disorders Gökhan S. Hotamışlıgil · Nature | 13 Dec 2006 | 9,214 |
| 3 | Biochemistry and molecular cell biology of diabetic complications Michael Brownlee · Nature | 13 Dec 2001 | 9,153 |
| 4 | Obesity is associated with macrophage accumulation in adipose tissue Stuart Phillip Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation | 15 Dec 2003 | 8,604 |
| 5 | The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function Gijs H. Goossens · Obesity Facts | 2017 | 8,505 |
| 6 | How mitochondria produce reactive oxygen species Michael P. Murphy · Biochemical Journal | 12 Dec 2008 | 8,245 |
| 7 | Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science | 1993 | 7,534 |
| 8 | Human Adipose Tissue Is a Source of Multipotent Stem Cells Patricia A. Zuk, Min Zhu, Peter H. Ashjian et al. · Molecular Biology of the Cell | Dec 2002 | 6,709 |
| 9 | Dose translation from animal to human studies revisited Shannon Reagan‐Shaw, Minakshi Nihal, Nihal Ahmad · The FASEB Journal | 17 Oct 2007 | 6,526 |
| 10 | Brown Adipose Tissue: Function and Physiological Significance Barbara Cannon, Jan Nedergaard · Physiological Reviews | 2004 | 6,496 |
| 11 | Central nervous system control of food intake Michael W. Schwartz, Stephen C. Woods, Daniel Porte et al. · Nature | Apr 2000 | 6,471 |
| 12 | Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation | 15 Dec 2003 | 5,834 |
| 13 | Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation Panu Jaakkola, David Robert Mole, Ya‐Min Tian et al. · Science | 20 Apr 2001 | 5,570 |
| 14 | Adipose Tissue as an Endocrine Organ Erin E. Kershaw, Jeffrey S. Flier · The Journal of Clinical Endocrinology & Metabolism | Jun 2004 | 5,530 |
| 15 | Mechanisms linking obesity to insulin resistance and type 2 diabetes Steven E. Kahn, Rebecca L. Hull, Kristina M. Utzschneider · Nature | Dec 2006 | 5,508 |
| 16 | Leptin and the regulation of body weight in mammals Jeffrey M. Friedman, Jeffrey L. Halaas · Nature | Oct 1998 | 5,424 |
| 17 | Insulin signalling and the regulation of glucose and lipid metabolism Alan R. Saltiel, C. Ronald Kahn · Nature | Dec 2001 | 5,360 |
| 18 | Increased oxidative stress in obesity and its impact on metabolic syndrome Shigetada Furukawa, Takuya Fujita, Michio Shimabukuro et al. · Journal of Clinical Investigation | 15 Dec 2004 | 5,349 |
| 19 | Stress, Adaptation, and Disease: Allostasis and Allostatic Load Bruce S. McEwen · Annals of the New York Academy of Sciences | May 1998 | 5,076 |
| 20 | Genetic studies of body mass index yield new insights for obesity biology The LifeLines Cohort Study et al. · Nature | 10 Feb 2015 | 4,954 |
| 21 | The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Toshimasa Yamauchi et al. · Nature Medicine | Aug 2001 | 4,950 |
| 22 | Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity Yukio Arita, Shinji Kihara, Noriyuki Bob Ouchi et al. · Biochemical and Biophysical Research Communications | Apr 1999 | 4,880 |
| 23 | A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature | 2012 | 4,823 |
| 24 | The hormone resistin links obesity to diabetes Claire M. Steppan, Shannon Terrell Bailey, Savitha Bhat et al. · Nature | 2001 | 4,790 |
| 25 | Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. Marco T. Castagna, Yoshimi Takai, Kozo Kaibuchi et al. · Journal of Biological Chemistry | Jul 1982 | 4,765 |
| 26 | Inflammation and insulin resistance Steven E. Shoelson · Journal of Clinical Investigation | 3 Jul 2006 | 4,703 |
| 27 | AMPK: a nutrient and energy sensor that maintains energy homeostasis David Grahame Hardie, Fiona A. Ross, Simon A. Hawley · Nature Reviews Molecular Cell Biology | 22 Mar 2012 | 4,622 |
| 28 | Adipokines in inflammation and metabolic disease Noriyuki Bob Ouchi, Jennifer L. Parker, Jesse J. Lugus et al. · Nature reviews. Immunology | 21 Jan 2011 | 4,601 |
| 29 | Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science | 28 Jul 1995 | 4,468 |
| 30 | Identification and Importance of Brown Adipose Tissue in Adult Humans Aaron M. Cypess, Sanaz Lehman, Gethin Williams et al. · New England Journal of Medicine | 8 Apr 2009 | 4,457 |
| 31 | Metabolism of Isolated Fat Cells Martin Rodbell · Journal of Biological Chemistry | Feb 1964 | 4,432 |
| 32 | Mitochondria, Oxidants, and Aging Robert S. Balaban, Shino Nemoto, Toren Finkel · Cell | Feb 2005 | 4,416 |
| 33 | Resveratrol improves health and survival of mice on a high-calorie diet Joseph A. Baur et al. · Nature | Nov 2006 | 4,279 |
| 34 | Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine | 7 Oct 2002 | 4,251 |
| 35 | Succinate is an inflammatory signal that induces IL-1β through HIF-1α Gillian M. Tannahill et al. · Nature | 22 Mar 2013 | 4,197 |
| 36 | Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 Zhidan Wu, Pere Puigserver, Ulf Andersson et al. · Cell | Jul 1999 | 4,156 |
| 37 | Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α Marie Lagouge, Carmen Argmann, Zachary Gerhart‐Hines et al. · Cell | 17 Nov 2006 | 4,041 |
| 38 | Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member Alexandra C. McPherron, Ann M. Lawler, Se‐Jin Lee · Nature | May 1997 | 4,036 |
| 39 | Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice Mary Ann Pelleymounter, Mary Jane Cullen, Mary Beth Baker et al. · Science | 28 Jul 1995 | 4,035 |
| 40 | Amino Acid Metabolism in Mammalian Cell Cultures Harry Eagle · Science | 21 Aug 1959 | 4,032 |
| 41 | Autophagy regulates lipid metabolism Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature | Apr 2009 | 4,022 |
| 42 | Ghrelin induces adiposity in rodents Matthias H. Tschöp, David L. Smiley, Mark L. Heiman · Nature | Oct 2000 | 3,964 |
| 43 | Therapeutic potential of resveratrol: the in vivo evidence Joseph A. Baur, David A. Sinclair · Nature Reviews Drug Discovery | 26 May 2006 | 3,951 |
| 44 | Inflammation, stress, and diabetes Kathryn E. Wellen, Gökhan S. Hotamışlıgil · Journal of Clinical Investigation | 2 May 2005 | 3,922 |
| 45 | Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus Henriette van Praag, Gerd Kempermann, Fred H. Gage · Nature Neuroscience | Mar 1999 | 3,922 |
| 46 | Effects of Size and Temperature on Metabolic Rate James F. Gillooly, James H. Brown, Geoffrey B. West et al. · Science | 21 Sep 2001 | 3,887 |
| 47 | A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis Pere Puigserver, Zhidan Wu, Cheol Won Park et al. · Cell | Mar 1998 | 3,881 |
| 48 | Inflammatory Mechanisms in Obesity Margaret F. Gregor, Gökhan S. Hotamışlıgil · Annual Review of Immunology | Mar 2011 | 3,743 |
| 49 | An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) Jürgen M. Lehmann, Linda B. Moore, Tracey A. Smith-Oliver et al. · Journal of Biological Chemistry | Jun 1995 | 3,648 |
| 50 | Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor Peter Tontonoz, Erding Hu, Bruce M. Spiegelman · Cell | Dec 1994 | 3,551 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.