Most cited papers in Advanced biosensing and bioanalysis techniques
What are the most cited papers in Advanced biosensing and bioanalysis techniques?
The most cited paper in Advanced biosensing and bioanalysis techniques is "Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays" (Tim R. Mosmann, 1983), with 56,216 citations. Next come "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity" (25,160) and "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (17,763).
Showing 50 of 100 papers. Every paper with more than 2,647 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays Tim R. Mosmann · Journal of Immunological Methods | Dec 1983 | 56,216 |
| 2 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity Andrew P. Feinberg, Bert Vogelstein · Analytical Biochemistry | Jul 1983 | 25,160 |
| 3 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science | 29 Jun 2012 | 17,763 |
| 4 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid K. Burton · Biochemical Journal | Feb 1956 | 14,144 |
| 5 | A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules Wendy D. Cornell, Piotr Cieplak, Christopher I. Bayly et al. · Journal of the American Chemical Society | May 1995 | 13,239 |
| 6 | Genome engineering using the CRISPR-Cas9 system F. Ann Ran, Patrick D. Hsu, Jason B. Wright et al. · Nature Protocols | 24 Oct 2013 | 11,982 |
| 7 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I Peter W. J. Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology | Jun 1977 | 11,663 |
| 8 | Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring Todd R. Golub, Donna K. Slonim, Pablo Tamayo et al. · Science | 15 Oct 1999 | 11,660 |
| 9 | A procedure for the isolation of deoxyribonucleic acid from micro-organisms Julius Marmur · Journal of Molecular Biology | Apr 1961 | 11,599 |
| 10 | Studies on transformation of Escherichia coli with plasmids Douglas Hanahan · Journal of Molecular Biology | Jun 1983 | 11,339 |
| 11 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Shuming Nie, Steven R. Emory · Science | 21 Feb 1997 | 10,238 |
| 12 | Loop-mediated isothermal amplification of DNA Tsugunori Notomi · Nucleic Acids Research | 15 Jun 2000 | 8,938 |
| 13 | Semiconductor Nanocrystals as Fluorescent Biological Labels Marcel P. Bruchez, Mario M. Moronne, Peter Gin et al. · Science | 25 Sep 1998 | 8,633 |
| 14 | Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology John Christopher Love, Lara A. Estroff, Jennah K. Kriebel et al. · Chemical Reviews | 25 Mar 2005 | 8,286 |
| 15 | Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics Xavier Michalet, Fabien F. Pinaud, Laurent A. Bentolila et al. · Science | 27 Jan 2005 | 7,777 |
| 16 | Folding DNA to create nanoscale shapes and patterns Paul W. K. Rothemund · Nature | 15 Mar 2006 | 7,535 |
| 17 | Intrinsic peroxidase-like activity of ferromagnetic nanoparticles Lizeng Gao, Jie Zhuang, Leng Nie et al. · Nature Nanotechnology | 26 Aug 2007 | 7,484 |
| 18 | Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA John R. Riordan, Johanna M. Rommens, Bat-Sheva Kerem et al. · Science | 8 Sep 1989 | 7,480 |
| 19 | Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Michael Walter Pfaffl · Nucleic Acids Research | May 2002 | 7,466 |
| 20 | Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection Warren C. W. Chan, Shuming Nie · Science | 25 Sep 1998 | 7,279 |
| 21 | Signaling Recognition Events with Fluorescent Sensors and Switches A. Prasanna de Silva, H. Q. Nimal Gunaratne, Thorfinnur Gunnlaugsson et al. · Chemical Reviews | Aug 1997 | 6,988 |
| 22 | Biosensing with plasmonic nanosensors Jeffrey N. Anker, W. Paige Hall, Olga Lyandres et al. · Nature Materials | 23 May 2008 | 6,794 |
| 23 | A DNA-based method for rationally assembling nanoparticles into macroscopic materials Chad Alexander Mirkin, Robert L. Letsinger, Robert C. Mucic et al. · Nature | Aug 1996 | 6,698 |
| 24 | Quantum dot bioconjugates for imaging, labelling and sensing Igor L. Medintz, H. Tetsuo Uyeda, Ellen R. Goldman et al. · Nature Materials | Jun 2005 | 6,217 |
| 25 | Localized Surface Plasmon Resonance Spectroscopy and Sensing Katherine A. Willets, Richard P. Van Duyne · Annual Review of Physical Chemistry | 26 Oct 2006 | 6,160 |
| 26 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers Jeffrey Vieira, Joachim W. Messing · Gene | Oct 1982 | 6,134 |
| 27 | Recent advances with liposomes as pharmaceutical carriers Vladimir P. Torchilin · Nature Reviews Drug Discovery | Feb 2005 | 5,273 |
| 28 | Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 John G. Doench, Nicolò Fusi, Meagan E. Sullender et al. · Nature Biotechnology | 18 Jan 2016 | 5,165 |
| 29 | Quantum-Sized Carbon Dots for Bright and Colorful Photoluminescence Ya‐Ping Sun, Bing Qin Zhou, Yi Lin et al. · Journal of the American Chemical Society | 23 May 2006 | 5,116 |
| 30 | Origins and Mechanisms of miRNAs and siRNAs Richard W. Carthew, Erik J. Sontheimer · Cell | Feb 2009 | 5,095 |
| 31 | DNA targeting specificity of RNA-guided Cas9 nucleases Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology | 21 Jul 2013 | 5,032 |
| 32 | Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes Lydia Alvarez‐Erviti, Yiqi Seow, HaiFang Yin et al. · Nature Biotechnology | 20 Mar 2011 | 4,972 |
| 33 | Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells Devika Basnagge Chithrani, Arezou A. Ghazani, Warren C. W. Chan · Nano Letters | Mar 2006 | 4,897 |
| 34 | In vivo cancer targeting and imaging with semiconductor quantum dots Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology | 18 Jul 2004 | 4,765 |
| 35 | Gold Nanoparticles in Chemical and Biological Sensing Krishnendu Saha, Sarit S. Agasti, Chaekyu Kim et al. · Chemical Reviews | 2 Feb 2012 | 4,628 |
| 36 | Nanostructures in Biodiagnostics Nathaniel L. Rosi, Chad Alexander Mirkin · Chemical Reviews | 23 Mar 2005 | 4,579 |
| 37 | Cancer nanotechnology: opportunities and challenges Mauro Ferrari · Nature reviews. Cancer | Mar 2005 | 4,555 |
| 38 | Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species Jiřı́ Homola · Chemical Reviews | 30 Jan 2008 | 4,533 |
| 39 | Molecular Computation of Solutions to Combinatorial Problems Leonard M. Adleman · Science | 11 Nov 1994 | 4,482 |
| 40 | Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles Robert Elghanian, James Justin Storhoff, Robert C. Mucic et al. · Science | 22 Aug 1997 | 4,399 |
| 41 | Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees et al. · Nature | 24 Oct 2017 | 4,380 |
| 42 | A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining Janet D. Rowley · Nature | Jun 1973 | 4,335 |
| 43 | Localized Surface Plasmon Resonance Sensors Kathryn M. Mayer, Jason H. Hafner · Chemical Reviews | 8 Jun 2011 | 4,332 |
| 44 | A System for Stable Expression of Short Interfering RNAs in Mammalian Cells Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science | 19 Apr 2002 | 4,319 |
| 45 | Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor Jean‐Philippe Coppé · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) | 13 Jan 2009 | 4,254 |
| 46 | Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface George P. Smith · Science | 14 Jun 1985 | 4,168 |
| 47 | Present and Future of Surface-Enhanced Raman Scattering Judith Langer et al. · ACS Nano | 3 Sep 2019 | 3,910 |
| 48 | Real-Time DNA Sequencing from Single Polymerase Molecules John S. Eid et al. · Science | 20 Nov 2008 | 3,878 |
| 49 | Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging Shoujun Zhu, Qingnan Meng, Lei Wang et al. · Angewandte Chemie International Edition | 28 Feb 2013 | 3,725 |
| 50 | Valley polarization in MoS2 monolayers by optical pumping Hualing Zeng, Junfeng Dai, Wang Yao et al. · Nature Nanotechnology | 17 Jun 2012 | 3,718 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.