Most cited papers in Advanced Synthetic Organic Chemistry
What are the most cited papers in Advanced Synthetic Organic Chemistry?
The most cited paper in Advanced Synthetic Organic Chemistry is "Amide bond formation: beyond the myth of coupling reagents" (Eric Valeur, Mark Bradley, 2008), with 2,203 citations. Next come "Rethinking amide bond synthesis" (2,162) and "Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?" (2,040).
Showing 50 of 100 papers. Every paper with more than 323 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Amide bond formation: beyond the myth of coupling reagents Eric Valeur, Mark Bradley · Chemical Society Reviews | 4 Dec 2008 | 2,203 |
| 2 | Rethinking amide bond synthesis Vijaya Raghavan Pattabiraman, Jeffrey W. Bode · Nature | Dec 2011 | 2,162 |
| 3 | Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone? Dean G. Brown, Jonas Boström · Journal of Medicinal Chemistry | 16 Nov 2015 | 2,040 |
| 4 | N-methoxy-n-methylamides as effective acylating agents Steven H. Nahm, Steven M. Weinreb · Tetrahedron Letters | 1981 | 1,798 |
| 5 | Amide bond formation and peptide coupling Christian Montalbetti, Virginie M. Falque · Tetrahedron | 20 Sep 2005 | 1,773 |
| 6 | Direct Synthesis of Amides from Alcohols and Amines with Liberation of H 2 Chidambaram Gunanathan, Yehoshoa Ben‐David, David Milstein · Science | 9 Aug 2007 | 1,284 |
| 7 | Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids (1998 to 1999) David O’Hagan · Natural Product Reports | 2000 | 1,253 |
| 8 | Catalytic Enantioselective Addition of Allylic Organometallic Reagents to Aldehydes and Ketones Scott E. Denmark, Jiping Fu · Chemical Reviews | 3 Jul 2003 | 1,235 |
| 9 | Metal-catalysed approaches to amide bond formation C. Liana Allen, Jonathan M. J. Williams · Chemical Society Reviews | 2011 | 1,055 |
| 10 | Reactions of Electron-Deficient Alkynes and Allenes under Phosphine Catalysis Xiyan Lu, Chunming Zhang, Zhenrong Xu · Accounts of Chemical Research | 12 May 2001 | 1,028 |
| 11 | The remarkable metal-catalysed olefin metathesis reaction Amir H. Hoveyda, Adil R. Zhugralin · Nature | Nov 2007 | 1,013 |
| 12 | Carbon–heteroatom bond formation catalysed by organometallic complexes John F. Hartwig · Nature | 17 Sep 2008 | 1,011 |
| 13 | Nucleophilic Phosphine Organocatalysis Joey L. Methot, William R. Roush · Advanced Synthesis & Catalysis | Aug 2004 | 982 |
| 14 | Recent Advances in Catalytic Enantioselective Michael Additions Norbert Krause, Anja Hoffmann‐Röder · Synthesis | 2001 | 948 |
| 15 | Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds Mary A. Blanchette, William Choy, Jeffery T. Davis et al. · Tetrahedron Letters | 1984 | 916 |
| 16 | Ynamides: A Modern Functional Group for the New Millennium Kyle A. DeKorver, Hongyan Li, Andrew G. Lohse et al. · Chemical Reviews | 29 Apr 2010 | 887 |
| 17 | Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals Joshua R. Dunetz, Javier Magano, Gerald A. Weisenburger · Organic Process Research & Development | 15 Nov 2015 | 829 |
| 18 | Phosphine-Catalyzed Asymmetric Organic Reactions Huanzhen Ni, Wai‐Lun Chan, Yixin Lü · Chemical Reviews | 11 Sep 2018 | 776 |
| 19 | The art of total synthesis through cascade reactions K. C. Nicolaou, Jason S. Chen · Chemical Society Reviews | 2009 | 754 |
| 20 | The chemistry of recently isolated naturally occurring quinazolinone alkaloids Santosh B. Mhaske, Narshinha P. Argade · Tetrahedron | 25 Aug 2006 | 750 |
| 21 | Phosphine-triggered synthesis of functionalized cyclic compounds Long‐Wu Ye, Jian Er Zhou, Yong Jin Tang · Chemical Society Reviews | 2008 | 744 |
| 22 | Enantioselective Organocatalytic Reductive Amination Richard Storer, Diane E. Carrera, Yike Ni et al. · Journal of the American Chemical Society | 14 Dec 2005 | 736 |
| 23 | Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution John F. Hartwig, Levi M. Stanley · Accounts of Chemical Research | 28 Sep 2010 | 719 |
| 24 | Enantioselective Construction of Quaternary Stereocenters Jens Christoffers, Alexander Mann · Angewandte Chemie International Edition | 17 Dec 2001 | 715 |
| 25 | Phosphoramidites: Marvellous Ligands in Catalytic Asymmetric Conjugate Addition Ben L. Feringa · Accounts of Chemical Research | 31 May 2000 | 701 |
| 26 | Four-Membered Ring-Containing Spirocycles: Synthetic Strategies and Opportunities Erick M. Carreira, Thomas C. Fessard · Chemical Reviews | 8 Jul 2014 | 634 |
| 27 | Synthesis of quinazolinones and quinazolines David J. Connolly, Declan Cusack, Timothy P. O’Sullivan et al. · Tetrahedron | 10 Aug 2005 | 627 |
| 28 | Synthesis of Functionalized Olefins by Cross and Ring-Closing Metatheses Arnab Chatterjee, John P. Morgan, Matthias Scholl et al. · Journal of the American Chemical Society | Apr 2000 | 616 |
| 29 | Asymmetric synthesis of amines by nucleophilic 1,2-addition of organometallic reagents to the CN-double bond Dieter Enders, Ulrich Reinhold · Tetrahedron Asymmetry | Jun 1997 | 568 |
| 30 | Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones Andrew G. Myers, Bryant H. Yang, Hou Chen et al. · Journal of the American Chemical Society | Jul 1997 | 566 |
| 31 | A mild, general method for conversion of esters to amides Anwer Basha, Michael F. Lipton, Steven M. Weinreb · Tetrahedron Letters | 1977 | 563 |
| 32 | Phosphinoaryl- and phosphinoalkyloxazolines as new chiral ligands for enantioselective catalysis: Very high enantioselectivity in palladium catalyzed allylic substitutions Jürgen Sprinz, Günter Helmchen · Tetrahedron Letters | Mar 1993 | 559 |
| 33 | Highly Enantioselective Iridium-Catalyzed Hydrogenation of Heteroaromatic Compounds, Quinolines Wenbo Wang, Sheng‐Mei Lu, Pengyu Yang et al. · Journal of the American Chemical Society | 9 Aug 2003 | 556 |
| 34 | Binding Characteristics of a Radiolabeled Agonist and Antagonist at Central Nervous System Alpha Noradrenergic Receptors David C. U’Prichard, David A. Greenberg, Solomon H. Snyder · Molecular Pharmacology | May 1977 | 553 |
| 35 | Multifunctional Chiral Phosphine Organocatalysts in Catalytic Asymmetric Morita−Baylis−Hillman and Related Reactions Yin Wei, Min Jun Shi · Accounts of Chemical Research | 16 Mar 2010 | 553 |
| 36 | Intramolecular reactions of N-acyliminium intermediates W. Nico Speckamp, Henk C. Hiemstra · Tetrahedron | 1985 | 550 |
| 37 | Macrocyclization by Ring‐Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations Ana Gradillas, Javier Pérez‐Castells · Angewandte Chemie International Edition | 21 Aug 2006 | 546 |
| 38 | Palladium-Catalyzed Enantioselective C-3 Allylation of 3-Substituted-1 H -Indoles Using Trialkylboranes Barry M. Trost, Jean Quancard · Journal of the American Chemical Society | 15 Apr 2006 | 535 |
| 39 | Some recent applications of α-amino nitrile chemistry Dieter Enders, John P. Shilvock · Chemical Society Reviews | 2000 | 530 |
| 40 | Amide Synthesis from Alcohols and Amines by the Extrusion of Dihydrogen Lars Ulrik Nordstrøm, Henning Vogt, Robert Madsen · Journal of the American Chemical Society | 5 Dec 2008 | 519 |
| 41 | Direct Catalytic Asymmetric α-Amination of Aldehydes Benjamin List · Journal of the American Chemical Society | 30 Apr 2002 | 518 |
| 42 | Catalytic asymmetric allylation of aldehydes Gary E. Keck, Kenneth H. Tarbet, Leo S. Geraci · Journal of the American Chemical Society | Sep 1993 | 511 |
| 43 | Recent Strategies for the Synthesis of Pyridine Derivatives Matthew Davenport Hill · Chemistry - A European Journal | 8 Sep 2010 | 509 |
| 44 | Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction Martin Edmund Maier · Angewandte Chemie International Edition | 16 Jun 2000 | 509 |
| 45 | Enantioselective Organocatalytic Hydride Reduction Stéphane G. Ouellet, Jamison B. Tuttle, David W. C. MacMillan · Journal of the American Chemical Society | 9 Dec 2004 | 504 |
| 46 | Enantioselective construction of remote quaternary stereocentres Tian‐Sheng Mei, Harshkumar H. Patel, Matthew S. Sigman · Nature | 8 Apr 2014 | 487 |
| 47 | Self‐Regeneration of Stereocenters (SRS)—Applications, Limitations, and Abandonment of a Synthetic Principle Dieter Seebàch, Andrea Rolf Sting, Matthias Hoffmann · Angewandte Chemie International Edition in English | Dec 1996 | 485 |
| 48 | Enantioselective Synthesis of α-Amino Nitriles from N -Benzhydryl Imines and HCN with a Chiral Bicyclic Guanidine as Catalyst Elias James Corey, Michael J. Grogan · Organic Letters | 24 May 1999 | 472 |
| 49 | Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications Imtiaz Ali Khan, Aliya Ibrar, Naeem Abbas et al. · European Journal of Medicinal Chemistry | 7 Feb 2014 | 470 |
| 50 | Total Synthesis of Complex Cyclotryptamine Alkaloids: Stereocontrolled Construction of Quaternary Carbon Stereocenters Alan Steven, Larry E. Overman · Angewandte Chemie International Edition | 25 Jun 2007 | 465 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.