Most cited papers in Alkaline Phosphatase Research Studies
What are the most cited papers in Alkaline Phosphatase Research Studies?
The most cited paper in Alkaline Phosphatase Research Studies is "Studies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate" (Charles Huggins, Clarence V. Hodges, 2002), with 3,204 citations. Next come "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product" (2,405) and "FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis" (1,891).
Showing 50 of 100 papers. Every paper with more than 392 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Studies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate Charles Huggins, Clarence V. Hodges · The Journal of Urology | Jul 2002 | 3,204 |
| 2 | Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product Yoshizumi Ishino, Hideo Shinagawa, K Makino et al. · Journal of Bacteriology | Dec 1987 | 2,405 |
| 3 | FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis Takashi Shimada, Hisashi Hasegawa, Y. Yamazaki et al. · Journal of Bone and Mineral Research | Mar 2004 | 1,891 |
| 4 | Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix Thomas A. Owen, Michael S. Aronow, Victoria Shalhoub et al. · Journal of Cellular Physiology | Jun 1990 | 1,580 |
| 5 | A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. Coli I. Purification and characterization of alkaline phosphatase Alan Garen, Cyrus Levinthal · Biochimica et Biophysica Acta | 1960 | 1,407 |
| 6 | Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling Veerle Janssens, Jozef Goris · Biochemical Journal | 25 Jan 2001 | 1,383 |
| 7 | THE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS Helen A. Padykula, Edith Herman · Journal of Histochemistry & Cytochemistry | May 1955 | 1,219 |
| 8 | Skeletal remodeling in health and disease Mone Zaidi · Nature Medicine | Jul 2007 | 1,077 |
| 9 | Bioactive calcium phosphate materials and applications in bone regeneration Jiwoon Jeong, Jung Hun Kim, Jung Hee Shim et al. · Biomaterials Research | 14 Jan 2019 | 1,065 |
| 10 | TnphoA: a transposon probe for protein export signals. Colin Manoil, Jon Beckwith · Proceedings of the National Academy of Sciences | Dec 1985 | 1,022 |
| 11 | Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation Kenneth E. S. Poole, Rutger Leo van Bezooijen, Nigel Loveridge et al. · The FASEB Journal | 25 Aug 2005 | 974 |
| 12 | Reaction mechanism of alkaline phosphatase based on crystal structures Eunice E. Kim, Harold W. Wyckoff · Journal of Molecular Biology | Mar 1991 | 959 |
| 13 | Alkaline phosphatase: Structure, expression and its function in bone mineralization Selvaraj Vimalraj · Gene | 6 Jun 2020 | 917 |
| 14 | Human Vascular Smooth Muscle Cells Undergo Vesicle-Mediated Calcification in Response to Changes in Extracellular Calcium and Phosphate Concentrations Joanne L. Reynolds, Alexis J. Joannides, Jeremy N. Skepper et al. · Journal of the American Society of Nephrology | 23 Oct 2004 | 916 |
| 15 | Alkaline Phosphatase: An Overview Ujjawal Sharma, Deeksha Pal, Rajendra Prasad · Indian Journal of Clinical Biochemistry | 25 Nov 2013 | 910 |
| 16 | Structure and Mechanism of Alkaline Phosphatase Jeff Coleman · Annual Review of Biophysics and Biomolecular Structure | Jun 1992 | 886 |
| 17 | Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1 Jonathan D. Goldberg, Hsien-Bin Huang, Young‐Guen Kwon et al. · Nature | Aug 1995 | 872 |
| 18 | Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization Lovisa Hessle, Kristen A. Johnson, H. Clarke Anderson et al. · Proceedings of the National Academy of Sciences | 24 Jun 2002 | 866 |
| 19 | The role of alkaline phosphatase in mineralization Ellis E. Golub, Kathleen Boesze‐Battaglia · Current Opinion in Orthopedics | 14 Aug 2007 | 835 |
| 20 | Influence of inorganic phosphate in the formation of phosphatases by Escherichia coli Annamaria Torriani · Biochimica et Biophysica Acta | 1960 | 816 |
| 21 | The influence of time, storage temperature, and substrate age on potential soil enzyme activity in acidic forest soils using MUB-linked substrates and l-DOPA Jared L. DeForest · Soil Biology and Biochemistry | 18 Mar 2009 | 810 |
| 22 | Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss Sébastien Lucas, Yasunori Omata, Jörg Hofmann et al. · Nature Communications | 29 Dec 2017 | 808 |
| 23 | A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay Alexander A. Baykov, Olga A. Evtushenko, Svetlana M. Avaeva · Analytical Biochemistry | Jun 1988 | 794 |
| 24 | Recombinant interleukin 12 cures mice infected with Leishmania major. Frederick P. Heinzel, David S. Schoenhaut, Ronald M. Rerko et al. · The Journal of Experimental Medicine | May 1993 | 767 |
| 25 | CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE 1B David Barford, Andrew Flint, Nicholas K. Tonks · Science | 11 Mar 1994 | 763 |
| 26 | The Mechanism of Mineralization and the Role of Alkaline Phosphatase in Health and Disease Hideo Orimo · Journal of Nippon Medical School | 2010 | 717 |
| 27 | THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES Zanvil A. Cohn, Belinda Benson · The Journal of Experimental Medicine | 1965 | 694 |
| 28 | Isolation and Characterization of MC3T3-E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential Dian Wang, Kurt Derek Christensen, Kanwal Chawla et al. · Journal of Bone and Mineral Research | Jun 1999 | 665 |
| 29 | Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth Marc C. Mumby, Gernot Walter · Physiological Reviews | Oct 1993 | 663 |
| 30 | Role of the Mouse ank Gene in Control of Tissue Calcification and Arthritis Andrew M. Ho, Michelle D. Johnson, David M. Kingsley · Science | 14 Jul 2000 | 652 |
| 31 | Protein Phosphatases: Properties and Role in Cellular Regulation Thomas S. Ingebritsen, Philip Cohen · Science | 22 Jul 1983 | 645 |
| 32 | The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors Stan Gronthos, Stephen E. Graves, Shuichi Ohta et al. · Blood | 15 Dec 1994 | 643 |
| 33 | Alkaline Phosphatase Activity in Mouse Teratoma Edward G. Bernstine, Martin Hooper, Simone Grandchamp et al. · Proceedings of the National Academy of Sciences | Dec 1973 | 631 |
| 34 | Lipid Oxidation Products Have Opposite Effects on Calcifying Vascular Cell and Bone Cell Differentiation Farhad Parhami, Andrew D. Morrow, Jennifer P. Balucan et al. · Arteriosclerosis Thrombosis and Vascular Biology | Apr 1997 | 621 |
| 35 | Alkaline Phosphatases José Luís Millán · Purinergic Signalling | Jun 2006 | 618 |
| 36 | Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone Monzur Murshed, Dympna Harmey, José Luís Millán et al. · Genes & Development | 15 Apr 2005 | 608 |
| 37 | Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification Frank Rutsch et al. · Nature Genetics | 25 Jul 2003 | 608 |
| 38 | Matrix vesicles and calcification H. Clarke Anderson · Current Rheumatology Reports | May 2003 | 600 |
| 39 | Soil acid and alkaline phosphatase activity as pH adjustment indicators Warren Albert Dick, Cheng Li, Pengwei Wang · Soil Biology and Biochemistry | Nov 2000 | 596 |
| 40 | Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. T. Kuber Sampath, A. Hari Reddi · Proceedings of the National Academy of Sciences | Dec 1981 | 592 |
| 41 | High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India Alok Sachan, Gupta Rk, Vinita Das et al. · American Journal of Clinical Nutrition | May 2005 | 587 |
| 42 | Molecular Biology of Matrix Vesicles H. Clarke Anderson · Clinical Orthopaedics and Related Research | May 1995 | 583 |
| 43 | Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia Michael P. Whyte et al. · New England Journal of Medicine | 7 Mar 2012 | 572 |
| 44 | Purification of the major protein-tyrosine-phosphatases of human placenta. Nicholas K. Tonks, Curtis D. Diltz, Edmond H. Fischer · Journal of Biological Chemistry | May 1988 | 572 |
| 45 | A Continuous Spectrophotometric Method for Measuring the Activity of Serum Alkaline Phosphatase George N Bowers Jr, R B McComb · Clinical Chemistry | Feb 1966 | 571 |
| 46 | The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation Suwimon Boonrungsiman, Eileen Gentleman, Raffaella Carzaniga et al. · Proceedings of the National Academy of Sciences | 24 Jul 2012 | 568 |
| 47 | Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors Joel E. Brown, Richard J. Cook, Pierre P Major et al. · JNCI Journal of the National Cancer Institute | 4 Jan 2005 | 565 |
| 48 | Characterization of the major protein-tyrosine-phosphatases of human placenta. Nicholas K. Tonks, Curtis D. Diltz, Edmond H. Fischer · Journal of Biological Chemistry | May 1988 | 557 |
| 49 | Bone recognition mechanism of porcine osteocalcin from crystal structure Quyen Q. Hoang, Frank Sicheri, Andrew J. Howard et al. · Nature | Oct 2003 | 556 |
| 50 | Biochemical Markers of Bone Metabolism: An Overview Robert H. Christenson · Clinical Biochemistry | Dec 1997 | 543 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.