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Topic · Endocrinology, Diabetes and Metabolism

Alkaline Phosphatase Research Studies

Alkaline Phosphatase Research Studies is a research topic within Endocrinology, Diabetes and Metabolism. Science Explorer counts 8.3k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the regulation of bone mineralization, with a specific emphasis on the role of alkaline phosphatase, hypophosphatasia, matrix vesicles, and the molecular mechanisms involved in mineralization regulation. It also covers topics such as enzyme replacement therapy, biomineralization, and the involvement of PHOSPHO1 and osteopontin in bone mineralization.

  • Alkaline Phosphatase
  • Bone Mineralization
  • Hypophosphatasia
  • Matrix Vesicles
  • Osteoblasts
  • Enzyme Replacement Therapy
  • Mineralization Regulation
  • Biomineralization
  • PHOSPHO1
  • Osteopontin
Research works
8.3k
fractional, since 1950
In the world top 10%
833
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+3%
the tick is no change
Largest producer
United States
27% of the 10 largest, 2022-now
Alkaline Phosphatase Research Studies

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Alkaline Phosphatase Research Studies research?

By volume, the United States and China publish the most (162 and 159 works in 2022-now).

By volume, 2022-now

  1. 1 United States 162 works
  2. 2 China 159 works
  3. 3 Japan 54 works
  4. 4 India 43 works
  5. 5 Germany 42 works
  6. 6 Spain 30 works
  7. 7 United Kingdom 29 works
  8. 8 France 27 works
  9. 9 Italy 22 works
  10. 10 Russia 22 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 27.4%China: 26.9%Japan: 9.1%India: 7.3%6 others listed: 29.2%27%largest
United States162 · 27.4%China159 · 26.9%Japan54 · 9.1%India43 · 7.3%6 others listed172 · 29.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Alkaline Phosphatase Research Studies research?

By volume in 2022-now, Universität Hamburg publishes the most Alkaline Phosphatase Research Studies research, followed by Centre National de la Recherche Scientifique and Russian Academy of Sciences.

By volume, 2022-now

  1. 1 Universität HamburgGermany 7 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 6 works
  3. 3 Russian Academy of SciencesRussia 4 works
  4. 4 University of WürzburgGermany 4 works
  5. 5 Sichuan UniversityChina 4 works
  6. 6 Washington University in St. LouisUnited States 4 works
  7. 7 Harvard UniversityUnited States 4 works
  8. 8 InsermFrance 4 works
  9. 9 University of MosulIraq 4 works
  10. 10 University of BaghdadIraq 4 works

Who are the leading researchers in Alkaline Phosphatase Research Studies?

The most-cited researchers publishing on Alkaline Phosphatase Research Studies include George Davey Smith, Cyrus Cooper and Gordon Henry Guyatt.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Cyrus Cooper United Kingdom 342k citations
  3. 3 Gordon Henry Guyatt Canada 315k citations
  4. 4 Marcello A. Tonelli Canada 268k citations
  5. 5 Jean‐Louis Vincent Belgium 262k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Alkaline Phosphatase Research Studies?

The most cited paper in Alkaline Phosphatase Research Studies is "Studies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate" (Charles Huggins, Clarence V. Hodges, 2002), with 3,204 citations. Next come "Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product" (2,405) and "FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis" (1,891).

Most cited papers
#PaperReleasedCitations
1 Studies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate Charles Huggins, Clarence V. Hodges · The Journal of Urology Jul 2002 3,204
2 Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product Yoshizumi Ishino, Hideo Shinagawa, K Makino et al. · Journal of Bacteriology Open access Dec 1987 2,405
3 FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis Takashi Shimada, Hisashi Hasegawa, Y. Yamazaki et al. · Journal of Bone and Mineral Research Mar 2004 1,891
4 Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix Thomas A. Owen, Michael S. Aronow, Victoria Shalhoub et al. · Journal of Cellular Physiology Jun 1990 1,580
5 A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. Coli I. Purification and characterization of alkaline phosphatase Alan Garen, Cyrus Levinthal · Biochimica et Biophysica Acta 1960 1,407
All 100 most cited papers, with filters and sorting

Where is Alkaline Phosphatase Research Studies research done?

The largest centres of Alkaline Phosphatase Research Studies research in 2022-now are Beijing (China), Tokyo (Japan), Shanghai (China) and Paris (France).

Largest cities, 2022-now

  1. 1 BeijingChina 18 works
  2. 2 TokyoJapan 17 works
  3. 3 ShanghaiChina 12 works
  4. 4 ParisFrance 12 works
  5. 5 MadridSpain 9 works
  6. 6 MoscowRussia 9 works
  7. 7 LondonUnited Kingdom 8 works
  8. 8 HamburgGermany 8 works
  9. 9 NanjingChina 7 works
  10. 10 Xi'anChina 7 works
See Alkaline Phosphatase Research Studies on the map

Is Alkaline Phosphatase Research Studies research growing?

Output in 2022-2025 was 3% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Alkaline Phosphatase Research Studies.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Alkaline Phosphatase Research Studies as a percentage of every work published that year, 0.0030% in 2024.

still counting0.020%0.040%Alkaline Phosphatase Research Studies0.0038% in 202519801990200020102020

Fractional works of Alkaline Phosphatase Research Studies over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Alkaline Phosphatase Research Studies9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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