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Topic · Endocrinology, Diabetes and Metabolism

Hormonal Regulation and Hypertension

Hormonal Regulation and Hypertension is a research topic within Endocrinology, Diabetes and Metabolism. Science Explorer counts 50k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the management, diagnosis, and treatment of Primary Aldosteronism, a condition characterized by the overproduction of aldosterone by the adrenal glands. The research covers topics such as case detection, cardiovascular events, glucocorticoid and mineralocorticoid receptor actions, hypertension, and the use of spironolactone therapy. Additionally, it explores the association with metabolic syndrome and renal injury.

  • Primary Aldosteronism
  • Aldosterone
  • Hypertension
  • Cardiovascular Events
  • Glucocorticoid
  • Mineralocorticoid Receptor
  • Adrenal Vein Sampling
  • Spironolactone Therapy
  • Metabolic Syndrome
  • Renal Injury
Research works
50k
fractional, since 1950
In the world top 10%
5k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+9%
the tick is no change
Largest producer
United States
36% of the 10 largest, 2022-now
Hormonal Regulation and Hypertension

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Hormonal Regulation and Hypertension research?

By volume, the United States and China publish the most (1.5k and 905 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.5k works
  2. 2 China 905 works
  3. 3 Japan 357 works
  4. 4 India 257 works
  5. 5 Italy 241 works
  6. 6 United Kingdom 233 works
  7. 7 Germany 218 works
  8. 8 Spain 158 works
  9. 9 France 157 works
  10. 10 Russia 137 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 35.8%China: 21.8%Japan: 8.6%India: 6.2%6 others listed: 27.6%36%largest
United States1,485 · 35.8%China905 · 21.8%Japan357 · 8.6%India257 · 6.2%6 others listed1,144 · 27.6%

Shares of the rows listed above, not of the whole node.

Which institutions lead Hormonal Regulation and Hypertension research?

By volume in 2022-now, Harvard University publishes the most Hormonal Regulation and Hypertension research, followed by Mayo Clinic and Inserm.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 73 works
  2. 2 Mayo ClinicUnited States 43 works
  3. 3 InsermFrance 40 works
  4. 4 University of MichiganUnited States 39 works
  5. 5 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 38 works
  6. 6 Chongqing Medical UniversityChina 31 works
  7. 7 National Institutes of HealthUnited States 27 works
  8. 8 Shanghai Jiao Tong UniversityChina 26 works
  9. 9 University of PaduaItaly 24 works
  10. 10 University of PennsylvaniaUnited States 23 works

Who are the leading researchers in Hormonal Regulation and Hypertension?

The most-cited researchers publishing on Hormonal Regulation and Hypertension include George Davey Smith, Mark J. Daly and Stacey L. Gabriel.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Stacey L. Gabriel United States 402k citations
  4. 4 Gad A. Getz United States 364k citations
  5. 5 John J.V. McMurray United Kingdom 349k citations
  6. 6 Hermann Brenner Germany 343k citations
  7. 7 Cyrus Cooper United Kingdom 342k citations
  8. 8 Emelia J. Benjamin United States 341k citations
  9. 9 Jun Wang China 340k citations
  10. 10 Giuseppe Remuzzi Italy 328k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Hormonal Regulation and Hypertension?

The most cited paper in Hormonal Regulation and Hypertension is "Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor" (Richard M. J. Palmer, Anthony G. Ferrige, Salvador Moncada, 1987), with 10,799 citations. Next come "The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure" (9,197) and "The Steroid and Thyroid Hormone Receptor Superfamily" (7,575).

Most cited papers
#PaperReleasedCitations
1 Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Richard M. J. Palmer, Anthony G. Ferrige, Salvador Moncada · Nature Jun 1987 10,799
2 The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure Bertram Pitt, Faiez M. Zannad, Willem J. Remme et al. · New England Journal of Medicine Open access 2 Sep 1999 9,197
3 The Steroid and Thyroid Hormone Receptor Superfamily Ronald M. Evans · Science Open access 13 May 1988 7,575
4 How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions* Robert Morris Sapolsky, L. Michael Romero, Allan U. Munck · Endocrine Reviews Feb 2000 6,620
5 Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol Björn Dahlöf, Richard B. Devereux, Sverre Erik Kjeldsen et al. · The Lancet Mar 2002 5,432
All 98 most cited papers, with filters and sorting

Where is Hormonal Regulation and Hypertension research done?

The largest centres of Hormonal Regulation and Hypertension research in 2022-now are Beijing (China), Tokyo (Japan), Paris (France) and London (United Kingdom).

Largest cities, 2022-now

  1. 1 BeijingChina 139 works
  2. 2 TokyoJapan 81 works
  3. 3 ParisFrance 76 works
  4. 4 LondonUnited Kingdom 72 works
  5. 5 BostonUnited States 71 works
  6. 6 ShanghaiChina 64 works
  7. 7 SeoulSouth Korea 59 works
  8. 8 MadridSpain 55 works
  9. 9 MoscowRussia 54 works
  10. 10 New YorkUnited States 53 works
See Hormonal Regulation and Hypertension on the map

Where is the best place to study Hormonal Regulation and Hypertension?

Among universities, judged by research, Harvard University, Vanderbilt University and University of Michigan score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.48%fractional works in this field (log) →share of work in the world top 10% →Vanderbilt UniversityHarvard UniversityUniversity of MichiganKarolinska Institutet
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 80.716.7%4.3×72 +34.3%
2Vanderbilt UniversityUnited States 67.919.0%6.0×23 +15.2%
3University of MichiganUnited States 63.416.4%4.9×39 -4.1%
4Karolinska InstitutetSweden 59.916.2%5.4×16 +6.3%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 58.513.5%6.9×38 +23.6%
6University of OttawaCanada 57.222.4%3.1×11 +26.0%
7University of PennsylvaniaUnited States 56.814.1%4.2×23 +48.7%
8Technische Universität DresdenGermany 56.123.4%4.0×12 +1.7%
9University of GroningenNetherlands 55.531.1%2.8×10 -20.7%
10Chongqing Medical UniversityChina 55.212.0%10.4×31 +74.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Hormonal Regulation and Hypertension, country by country

Is Hormonal Regulation and Hypertension research growing?

Output in 2022-2025 was 9% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Hormonal Regulation and Hypertension.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Hormonal Regulation and Hypertension as a percentage of every work published that year, 0.026% in 2024.

still counting0.050%0.10%0.15%Hormonal Regulation and Hypertension0.026% in 202519801990200020102020

Fractional works of Hormonal Regulation and Hypertension over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Hormonal Regulation and Hypertension10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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