Most cited papers in Apelin-related biomedical research
What are the most cited papers in Apelin-related biomedical research?
The most cited paper in Apelin-related biomedical research is "Mechanisms of angiogenesis and arteriogenesis" (Peter Carmeliet, 2000), with 4,189 citations. Next come "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" (2,846) and "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver" (2,775).
Showing 50 of 100 papers. Every paper with more than 550 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Mechanisms of angiogenesis and arteriogenesis Peter Carmeliet · Nature Medicine | Apr 2000 | 4,189 |
| 2 | Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome Takashi Kadowaki · Journal of Clinical Investigation | 3 Jul 2006 | 2,846 |
| 3 | Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver Bruno Costa‐Silva et al. · Nature Cell Biology | 18 May 2015 | 2,775 |
| 4 | Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun James I. Morgan, Tom Curran · Annual Review of Neuroscience | Mar 1991 | 2,674 |
| 5 | The regulation and function of c-fos and other immediate early genes in the nervous system Morgan Sheng, Michael E. Greenberg · Neuron | Apr 1990 | 2,470 |
| 6 | Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis James P. Herman, William E. Cullinan · Trends in Neurosciences | Feb 1997 | 2,291 |
| 7 | Exercise builds brain health: key roles of growth factor cascades and inflammation Carl W. Cotman, Nicole C. Berchtold, Lori‐Ann Christie · Trends in Neurosciences | Sep 2007 | 2,289 |
| 8 | Endothelial cells in physiology and in the pathophysiology of vascular disorders. Douglas B. Cines, Eleanor S. Pollak, Clayton A. Buck et al. · PubMed | 15 May 1998 | 2,267 |
| 9 | Role of Brain Insulin Receptor in Control of Body Weight and Reproduction Jens C. Brüning, Dinesh Gautam, Deborah Jane Burks et al. · Science | 22 Sep 2000 | 2,255 |
| 10 | International Union of Pharmacology. XXIII. The Angiotensin II Receptors Marc de Gasparo, Kevin J. Catt, Tadashi Inagami et al. · Pharmacological Reviews | Sep 2000 | 2,142 |
| 11 | Inflammation in obesity, diabetes, and related disorders Theresa V. Rohm, Daniel T. Meier, Jerrold M. Olefsky et al. · Immunity | 2022 | 2,074 |
| 12 | A Transgenic Model of Visceral Obesity and the Metabolic Syndrome Hiroaki Masuzaki, J. Paterson, Hiroshi Shinyama et al. · Science | 7 Dec 2001 | 1,767 |
| 13 | Physiology of Local Renin-Angiotensin Systems Martin Paul, Ali Poyan Mehr, Reinhold Kreutz · Physiological Reviews | 30 Jun 2006 | 1,747 |
| 14 | Molecular Mechanisms of Human Hypertension Richard P. Lifton, Ali G. Gharavi, David S. Geller · Cell | Feb 2001 | 1,705 |
| 15 | Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata et al. · Biochemical and Biophysical Research Communications | Oct 1998 | 1,697 |
| 16 | Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4 Hai U. Wang, Zhou‐Feng Chen, David J. Anderson · Cell | May 1998 | 1,685 |
| 17 | Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction Jeong‐a Kim, Monica Montagnani, Kwang Kon Koh et al. · Circulation | 17 Apr 2006 | 1,654 |
| 18 | Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor Joan M. Vaughan, Cynthia J. Donaldson, Jackson Cioni Bittencourt et al. · Nature | Nov 1995 | 1,498 |
| 19 | Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Junichi Sadoshima, Seigo Izumo · Circulation Research | Sep 1993 | 1,429 |
| 20 | The pivotal link between ACE2 deficiency and SARS-CoV-2 infection Paolo Verdecchia, Claudio Cavallini, Antonio Spanevello et al. · European Journal of Internal Medicine | 20 Apr 2020 | 1,295 |
| 21 | Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation Fred Lembeck, Peter D. Holzer · Naunyn-Schmiedeberg s Archives of Pharmacology | 1979 | 1,204 |
| 22 | Endothelial Dysfunction Dierk Endemann, Ernesto L. Schiffrin · Journal of the American Society of Nephrology | Aug 2004 | 1,195 |
| 23 | Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction Arunkumar Achari, Sushil Kumar Jain · International Journal of Molecular Sciences | 21 Jun 2017 | 1,186 |
| 24 | The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7) Robson A.S. Santos, Walkyria Oliveira Sampaio, Andréia Carvalho Alzamora et al. · Physiological Reviews | 24 Dec 2017 | 1,174 |
| 25 | Adiponectin and protection against type 2 diabetes mellitus Joachim Spranger, Anja Kroke, Matthias Möhlig et al. · The Lancet | 2003 | 1,130 |
| 26 | Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology Steven J. Forrester, George W. Booz, Curt D. Sigmund et al. · Physiological Reviews | 6 Jun 2018 | 1,109 |
| 27 | Endothelial Function Amir Lerman, Andreas Michael Zeiher · Circulation | 24 Jan 2005 | 1,095 |
| 28 | Essential Hypertension Oscar A. Carretero, Suzanne Oparil · Circulation | 25 Jan 2000 | 1,093 |
| 29 | Adipokines in health and disease Mathias Faßhauer, Matthias Blüher · Trends in Pharmacological Sciences | 25 May 2015 | 1,056 |
| 30 | Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis Ralf H. Adams, George A. Wilkinson, Chana Weiss et al. · Genes & Development | Feb 1999 | 1,039 |
| 31 | Role of Akt Signaling in Vascular Homeostasis and Angiogenesis Ichiro Shiojima, Kenneth Walsh · Circulation Research | 28 Jun 2002 | 1,023 |
| 32 | MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia J. Bernhagen, Thierry Calandra, Robert A. Mitchell et al. · Nature | 21 Oct 1993 | 1,005 |
| 33 | Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Daniel Dumont, Gérard Gradwohl, Gua-Hua Fong et al. · Genes & Development | 15 Aug 1994 | 992 |
| 34 | Pancreatic regulation of glucose homeostasis Pia V. Röder, Bingbing Wu, Yixian Liu et al. · Experimental & Molecular Medicine | 11 Mar 2016 | 990 |
| 35 | Molecular and Cellular Mechanisms of Angiotensin II-Mediated Cardiovascular and Renal Diseases Shokei Kim, Hiroshi Iwao · Pharmacological Reviews | Mar 2000 | 987 |
| 36 | The Intima Stephen M. Schwartz, Denis deBlois, Edward R. O’Brien · Circulation Research | Sep 1995 | 979 |
| 37 | A meta-analytic review of research on hostility and physical health. Todd Q. Miller, Timothy W. Smith, Charles W. Turner et al. · Psychological Bulletin | Mar 1996 | 956 |
| 38 | Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity Jérémie Boucher, Bernard Masri, Danièle Daviaud et al. · Endocrinology | 27 Jan 2005 | 907 |
| 39 | 11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action Karen E. Chapman, Megan C. Holmes, Jonathan R. Seckl · Physiological Reviews | Jul 2013 | 896 |
| 40 | Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme Dan W. Harmer, Maureen Gilbert, Richard A. Borman et al. · FEBS Letters | 7 Nov 2002 | 881 |
| 41 | Adiponectin Expression From Human Adipose Tissue Philip A. Kern, Gina B. Di Gregorio, Tong Lü et al. · Diabetes | Jul 2003 | 879 |
| 42 | Adiponectin as an anti-inflammatory factor Noriyuki Bob Ouchi, Kenneth Walsh · Clinica Chimica Acta | 5 Feb 2007 | 878 |
| 43 | Immunobiology of the TAM receptors Greg Lemke, Carla Vanina Rothlin · Nature reviews. Immunology | 18 Apr 2008 | 869 |
| 44 | Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism Kerry B. Goralski, Tanya C. McCarthy, Elyisha A. Hanniman et al. · Journal of Biological Chemistry | 17 Jul 2007 | 867 |
| 45 | 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress Yuri V. Kotelevtsev, Megan C. Holmes, Ann N. Burchell et al. · Proceedings of the National Academy of Sciences | 23 Dec 1997 | 858 |
| 46 | Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis Nicholas W. Gale, Sacha J. Holland, David M. Valenzuela et al. · Neuron | Jul 1996 | 851 |
| 47 | Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. Brian J. Van Lenten, Susan Y. Hama, Frederick C. de Beer et al. · Journal of Clinical Investigation | Dec 1995 | 846 |
| 48 | Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 Robert S. Ames et al. · Nature | 16 Sep 1999 | 793 |
| 49 | TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge Alicia A. Nugent et al. · Neuron | 2 Jan 2020 | 787 |
| 50 | Stress, inflammation and cardiovascular disease Paul H. Black, Lisa D Garbutt · Journal of Psychosomatic Research | 2002 | 787 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.