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Topic · Pharmacology

Apelin-related biomedical research

Apelin-related biomedical research is a research topic within Pharmacology. Science Explorer counts 11k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of apelin, a novel adipokine, and its receptor APJ in various physiological processes such as cardiovascular regulation, angiogenesis, obesity, diabetes, and neuroprotection. The research covers molecular properties, tissue distribution, signaling pathways, therapeutic potential, and pathophysiological implications of the apelin/APJ system.

  • Apelin
  • APJ Receptor
  • Cardiovascular
  • Angiogenesis
  • Obesity
  • Diabetes
  • Hypertension
  • Neuroprotective
  • Adipokine
  • G Protein-Coupled Receptor
Research works
11k
fractional, since 1950
In the world top 10%
1.1k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+8%
the tick is no change
Largest producer
China
32% of the 10 largest, 2022-now
Apelin-related biomedical research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Apelin-related biomedical research research?

By volume, China and the United States publish the most (432 and 301 works in 2022-now).

By volume, 2022-now

  1. 1 China 432 works
  2. 2 United States 301 works
  3. 3 Türkiye 109 works
  4. 4 India 109 works
  5. 5 Iran 81 works
  6. 6 Egypt 74 works
  7. 7 Russia 72 works
  8. 8 Iraq 67 works
  9. 9 Japan 62 works
  10. 10 Indonesia 58 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 31.6%United States: 22.1%Türkiye: 8.0%India: 8.0%6 others listed: 30.3%32%largest
China432 · 31.6%United States301 · 22.1%Türkiye109 · 8.0%India109 · 8.0%6 others listed414 · 30.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Apelin-related biomedical research research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Apelin-related biomedical research research, followed by Islamic Azad University, Tehran and Central South University.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 19 works
  2. 2 Islamic Azad University, TehranIran 17 works
  3. 3 Central South UniversityChina 12 works
  4. 4 University of BaghdadIraq 12 works
  5. 5 InsermFrance 11 works
  6. 6 Harvard UniversityUnited States 11 works
  7. 7 Nanjing Medical UniversityChina 10 works
  8. 8 Capital Medical UniversityChina 10 works
  9. 9 Sun Yat-sen UniversityChina 10 works
  10. 10 Shanghai Jiao Tong UniversityChina 10 works

Who are the leading researchers in Apelin-related biomedical research?

The most-cited researchers publishing on Apelin-related biomedical research include John J.V. McMurray, Jun Wang and Giuseppe Remuzzi.

  1. 1 John J.V. McMurray United Kingdom 349k citations
  2. 2 Jun Wang China 340k citations
  3. 3 Giuseppe Remuzzi Italy 328k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 Josef Coresh United States 272k citations
  6. 6 Amirhossein Sahebkar Iran 258k citations
  7. 7 Valentı́n Fuster United States 257k citations
  8. 8 Piotr P. Ponikowski Poland 253k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Apelin-related biomedical research?

The most cited paper in Apelin-related biomedical research is "Mechanisms of angiogenesis and arteriogenesis" (Peter Carmeliet, 2000), with 4,189 citations. Next come "Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome" (2,846) and "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver" (2,775).

Most cited papers
#PaperReleasedCitations
1 Mechanisms of angiogenesis and arteriogenesis Peter Carmeliet · Nature Medicine Apr 2000 4,189
2 Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome Takashi Kadowaki · Journal of Clinical Investigation Open access 3 Jul 2006 2,846
3 Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver Bruno Costa‐Silva et al. · Nature Cell Biology Open access 18 May 2015 2,775
4 Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun James I. Morgan, Tom Curran · Annual Review of Neuroscience Mar 1991 2,674
5 The regulation and function of c-fos and other immediate early genes in the nervous system Morgan Sheng, Michael E. Greenberg · Neuron Apr 1990 2,470
All 100 most cited papers, with filters and sorting

Where is Apelin-related biomedical research research done?

The largest centres of Apelin-related biomedical research research in 2022-now are Beijing (China), Shanghai (China), Baghdad (Iraq) and Guangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Baghdad.

Largest cities, 2022-now

  1. 1 BeijingChina 48 works
  2. 2 ShanghaiChina 30 works
  3. 3 BaghdadIraq 28 works
  4. 4 GuangzhouChina 27 works
  5. 5 MoscowRussia 24 works
  6. 6 IstanbulTürkiye 23 works
  7. 7 TehranIran 22 works
  8. 8 ParisFrance 19 works
  9. 9 NanjingChina 18 works
  10. 10 ChangshaChina 17 works

Where it is the local speciality

  1. BaghdadIQ · 27.6 works7.0×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Apelin-related biomedical research than the world average.

See Apelin-related biomedical research on the map

Where is the best place to study Apelin-related biomedical research?

Among universities, judged by research, Central South University, Medical University of Warsaw and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 13.9%fractional works in this field (log) →share of work in the world top 10% →Medical University o…Central South Univer…Capital Medical Univ…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Central South UniversityChina 68.426.4%3.7×12 +37.6%
2Medical University of WarsawPoland 63.829.6%21.1×8 +195.1%
3Harvard UniversityUnited States 50.68.5%1.9×11 +42.8%
4Capital Medical UniversityChina 49.121.9%5.4×10 -7.6%
5Islamic Azad University, TehranIran 41.51.0%6.0×18 -30.2%
6Sun Yat-sen UniversityChina 41.520.4%2.6×10 -6.9%
7University of BaghdadIraq 37.60.0%9.7×12 +388.4%
8Nanjing Medical UniversityChina 33.18.3%6.6×10 -18.1%
9Cairo UniversityEgypt 33.14.9%6.3×8 +95.8%
10Shanghai Jiao Tong UniversityChina 32.918.0%1.9×10 -18.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Apelin-related biomedical research, country by country

Is Apelin-related biomedical research research growing?

Output in 2022-2025 was 8% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are Apelin-related biomedical research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Apelin-related biomedical research as a percentage of every work published that year, 0.010% in 2024.

still counting0.0050%0.010%0.015%Apelin-related biomedical research0.0089% in 202519801990200020102020

Fractional works of Apelin-related biomedical research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Apelin-related biomedical research10.4% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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