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Topic · Pharmacology

Drug-Induced Adverse Reactions

Drug-Induced Adverse Reactions is a research topic within Pharmacology. Science Explorer counts 24k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on hypersensitivity reactions to various drugs and medications, including the role of specific HLA genotypes such as HLA-B*5701, HLA-B*1502, and HLA-B*5801 in predicting severe cutaneous adverse reactions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. The cluster also covers topics related to drug-induced hypersensitivity syndrome (DIHS), delayed drug hypersensitivity reactions, and the use of genetic screening to prevent abacavir hypersensitivity reactions.

  • HLA-B*5701
  • Stevens-Johnson Syndrome
  • Toxic Epidermal Necrolysis
  • Drug Hypersensitivity
  • Abacavir
  • Carbamazepine
  • Allopurinol
  • DRESS Syndrome
  • Immediate Allergic Reactions
  • HLA Genotyping
Research works
24k
fractional, since 1950
In the world top 10%
2.5k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+10%
the tick is no change
Largest producer
United States
36% of the 10 largest, 2022-now
Drug-Induced Adverse Reactions

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Drug-Induced Adverse Reactions research?

By volume, the United States and China publish the most (1.2k and 419 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.2k works
  2. 2 China 419 works
  3. 3 India 376 works
  4. 4 Japan 255 works
  5. 5 France 219 works
  6. 6 Spain 206 works
  7. 7 United Kingdom 181 works
  8. 8 Türkiye 167 works
  9. 9 Germany 153 works
  10. 10 Italy 148 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 35.7%China: 12.7%India: 11.4%Japan: 7.7%6 others listed: 32.5%36%largest
United States1,180 · 35.7%China419 · 12.7%India376 · 11.4%Japan255 · 7.7%6 others listed1,074 · 32.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Drug-Induced Adverse Reactions research?

By volume in 2022-now, Harvard University publishes the most Drug-Induced Adverse Reactions research, followed by Prince Sattam Bin Abdulaziz University and All India Institute of Medical Sciences.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 57 works
  2. 2 Prince Sattam Bin Abdulaziz UniversitySaudi Arabia 41 works
  3. 3 All India Institute of Medical SciencesIndia 31 works
  4. 4 Mayo ClinicUnited States 31 works
  5. 5 InsermFrance 29 works
  6. 6 Vanderbilt UniversityUnited States 26 works
  7. 7 The Ohio State UniversityUnited States 20 works
  8. 8 Sağlık Bilimleri ÜniversitesiTürkiye 19 works
  9. 9 University of TorontoCanada 17 works
  10. 10 Yale UniversityUnited States 17 works

Who are the leading researchers in Drug-Induced Adverse Reactions?

The most-cited researchers publishing on Drug-Induced Adverse Reactions include David Moher, Mark J. Daly and Giuseppe Remuzzi.

  1. 1 David Moher Canada 898k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Giuseppe Remuzzi Italy 328k citations
  4. 4 Gregory Y.H. Lip United Kingdom 311k citations
  5. 5 Dan J. Stein South Africa 306k citations
  6. 6 Hagop M. Kantarjian United States 273k citations
  7. 7 Jean‐Louis Vincent Belgium 262k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Drug-Induced Adverse Reactions?

The most cited paper in Drug-Induced Adverse Reactions is "Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients" (Munir Pirmohamed, Sally James, Shaun Meakin et al., 2004), with 3,262 citations. Next come "Sarcoidosis" (1,973) and "HLA-B*5701 Screening for Hypersensitivity to Abacavir" (1,847).

Most cited papers
#PaperReleasedCitations
1 Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients Munir Pirmohamed, Sally James, Shaun Meakin et al. · BMJ Open access Jul 2004 3,262
2 Sarcoidosis Michael C. Iannuzzi, Benjamin A. Rybicki, Alvin S. Teirstein · New England Journal of Medicine 21 Nov 2007 1,973
3 HLA-B*5701 Screening for Hypersensitivity to Abacavir Simon Alexander Mallal, Elizabeth Jane Phillips, Giampiero Carosi et al. · New England Journal of Medicine Open access 6 Feb 2008 1,847
4 A marker for Stevens–Johnson syndrome Wen‐Hung Chung, Wen‐Hung Chung, Hong‐Shang Hong et al. · Nature Apr 2004 1,760
5 Cremophor EL Hans A. J. Gelderblom, Jaap Verweij, Kees Nooter et al. · European Journal of Cancer Sep 2001 1,658
All 100 most cited papers, with filters and sorting

Where is Drug-Induced Adverse Reactions research done?

The largest centres of Drug-Induced Adverse Reactions research in 2022-now are Paris (France), Tokyo (Japan), Madrid (Spain) and Beijing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Al Kharj and Nashville.

Largest cities, 2022-now

  1. 1 ParisFrance 67 works
  2. 2 TokyoJapan 66 works
  3. 3 MadridSpain 60 works
  4. 4 BeijingChina 54 works
  5. 5 LondonUnited Kingdom 53 works
  6. 6 BostonUnited States 51 works
  7. 7 IstanbulTürkiye 50 works
  8. 8 New YorkUnited States 49 works
  9. 9 SeoulSouth Korea 42 works
  10. 10 Al KharjSaudi Arabia 41 works

Where it is the local speciality

  1. Al KharjSA · 41.3 works32×
  2. NashvilleUS · 30.0 works6.8×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Drug-Induced Adverse Reactions than the world average.

See Drug-Induced Adverse Reactions on the map

Where is the best place to study Drug-Induced Adverse Reactions?

Among universities, judged by research, Vanderbilt University, Harvard University and University of Hong Kong score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 19.96%fractional works in this field (log) →share of work in the world top 10% →University of Hong K…Vanderbilt UniversityHarvard UniversityThe University of Me…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Vanderbilt UniversityUnited States 79.029.3%8.7×26 +60.7%
2Harvard UniversityUnited States 74.619.2%4.2×57 -13.8%
3University of Hong KongChina 58.729.7%2.1×8 +68.8%
4The University of MelbourneAustralia 53.018.0%2.8×13 +22.7%
5University of TorontoCanada 52.021.0%2.0×17 -13.9%
6Yale UniversityUnited States 48.514.1%3.6×17 +116.3%
7Sichuan UniversityChina 48.418.0%1.6×16 +128.9%
8University of CopenhagenDenmark 48.116.4%3.2×12 +10.5%
9University of CincinnatiUnited States 47.917.1%4.5×11 +28.6%
10Zhejiang UniversityChina 46.016.8%1.4×16 +98.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Drug-Induced Adverse Reactions, country by country

Is Drug-Induced Adverse Reactions research growing?

Output in 2022-2025 was 10% higher than in 2018-2021, peaking in 2021. The fastest-growing topics are Drug-Induced Adverse Reactions.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Drug-Induced Adverse Reactions as a percentage of every work published that year, 0.019% in 2024.

still counting0.020%0.040%Drug-Induced Adverse Reactions0.019% in 202519801990200020102020

Fractional works of Drug-Induced Adverse Reactions over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Drug-Induced Adverse Reactions10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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