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Topic · Pharmacology

Inflammatory mediators and NSAID effects

Inflammatory mediators and NSAID effects is a research topic within Pharmacology. Science Explorer counts 42k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the use of cyclooxygenase-2 (COX-2) inhibitors, such as rofecoxib, celecoxib, and naproxen, in the context of inflammation and cancer. It explores the gastrointestinal and cardiovascular toxicity, chemopreventive effects, and potential risks associated with these drugs. The cluster also delves into the molecular biology of prostaglandins, particularly prostaglandin E2, and their role in modulating immune responses and promoting cancer growth.

  • Cyclooxygenase-2 Inhibitors
  • Inflammation
  • Cancer
  • Prostaglandins
  • NSAIDs
  • Cardiovascular Risk
  • Colorectal Cancer
  • Chemoprevention
  • Prostaglandin E2
  • COX-2
Research works
42k
fractional, since 1950
In the world top 10%
4.3k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-14%
the tick is no change
Largest producer
China
32% of the 10 largest, 2022-now
Inflammatory mediators and NSAID effects

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Inflammatory mediators and NSAID effects research?

By volume, China and the United States publish the most (826 and 689 works in 2022-now).

By volume, 2022-now

  1. 1 China 826 works
  2. 2 United States 689 works
  3. 3 India 283 works
  4. 4 Japan 161 works
  5. 5 South Korea 133 works
  6. 6 United Kingdom 103 works
  7. 7 Italy 96 works
  8. 8 Germany 95 works
  9. 9 Russia 92 works
  10. 10 Egypt 91 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 32.1%United States: 26.8%India: 11.0%Japan: 6.3%6 others listed: 23.7%32%largest
China826 · 32.1%United States689 · 26.8%India283 · 11.0%Japan161 · 6.3%6 others listed610 · 23.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Inflammatory mediators and NSAID effects research?

By volume in 2022-now, Harvard University publishes the most Inflammatory mediators and NSAID effects research, followed by Sun Yat-sen University and Sichuan University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 28 works
  2. 2 Sun Yat-sen UniversityChina 19 works
  3. 3 Sichuan UniversityChina 18 works
  4. 4 Shanghai Jiao Tong UniversityChina 17 works
  5. 5 Cairo UniversityEgypt 15 works
  6. 6 University of North Carolina at Chapel HillUnited States 14 works
  7. 7 Russian Academy of SciencesRussia 14 works
  8. 8 Peking UniversityChina 14 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 13 works
  10. 10 Zhejiang UniversityChina 13 works

Who are the leading researchers in Inflammatory mediators and NSAID effects?

The most-cited researchers publishing on Inflammatory mediators and NSAID effects include George Davey Smith, Walter Churchill Willett and Guido Kroemer.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Walter Churchill Willett United States 411k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Bert Vogelstein United States 373k citations
  5. 5 John J.V. McMurray United Kingdom 349k citations
  6. 6 Hermann Brenner Germany 343k citations
  7. 7 Shizuo Akira Japan 342k citations
  8. 8 Cyrus Cooper United Kingdom 342k citations
  9. 9 Jun Wang China 340k citations
  10. 10 Giuseppe Remuzzi Italy 328k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Inflammatory mediators and NSAID effects?

The most cited paper in Inflammatory mediators and NSAID effects is "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" (Robert F. Furchgott, John V. Zawadzki, 1980), with 12,123 citations. Next come "Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs" (8,642) and "In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation" (4,236).

Most cited papers
#PaperReleasedCitations
1 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature Nov 1980 12,123
2 Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs John Robert Vane · Nature New Biology Jun 1971 8,642
3 In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation Calamita, Elisa, Schmid, Martin, Kunz, Manuel et al. · Figshare Open access Nov 2019 4,236
4 Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis Claire Bombardier, Loren Laine, Alise S. Reicin et al. · New England Journal of Medicine Open access 23 Nov 2000 4,053
5 Prostaglandins and Inflammation Emanuela Ricciotti, Garret A. FitzGerald · Arteriosclerosis Thrombosis and Vascular Biology Open access 20 Apr 2011 3,833
All 100 most cited papers, with filters and sorting

Where is Inflammatory mediators and NSAID effects research done?

The largest centres of Inflammatory mediators and NSAID effects research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Seoul (South Korea). Among places with at least 20 works in it, it is an unusually large share of all research in Giza.

Largest cities, 2022-now

  1. 1 BeijingChina 78 works
  2. 2 ShanghaiChina 55 works
  3. 3 GuangzhouChina 55 works
  4. 4 SeoulSouth Korea 53 works
  5. 5 MoscowRussia 44 works
  6. 6 TokyoJapan 43 works
  7. 7 NanjingChina 33 works
  8. 8 LondonUnited Kingdom 31 works
  9. 9 WuhanChina 31 works
  10. 10 ChengduChina 29 works

Where it is the local speciality

  1. GizaEG · 22.5 works4.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Inflammatory mediators and NSAID effects than the world average.

See Inflammatory mediators and NSAID effects on the map

Where is the best place to study Inflammatory mediators and NSAID effects?

Among universities, judged by research, Harvard University, Cairo University and Vanderbilt University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.32%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityCairo UniversitySichuan UniversityVanderbilt University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 77.518.0%2.6×28 -22.1%
2Cairo UniversityEgypt 63.417.5%5.9×15 +36.8%
3Vanderbilt UniversityUnited States 52.913.7%4.7×11 -4.3%
4Sichuan UniversityChina 51.517.2%2.5×18 -2.4%
5Sun Yat-sen UniversityChina 50.716.5%2.8×19 -9.8%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 49.817.8%3.8×13 +25.4%
7Huazhong University of Science and TechnologyChina 47.826.5%2.1×13 -13.5%
8Southern Medical UniversityChina 46.517.9%6.0×12 +3.8%
9Wenzhou Medical UniversityChina 42.416.3%6.6×11 -25.2%
10Karolinska InstitutetSweden 41.911.8%4.6×9 -37.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Inflammatory mediators and NSAID effects, country by country

Is Inflammatory mediators and NSAID effects research growing?

Output in 2022-2025 was 14% lower than in 2018-2021, peaking in 2012.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Inflammatory mediators and NSAID effects as a percentage of every work published that year, 0.016% in 2024.

still counting0.050%0.10%0.15%Inflammatory mediators and NSAID effects0.015% in 202519801990200020102020

Fractional works of Inflammatory mediators and NSAID effects over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Inflammatory mediators and NSAID effects10.3% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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