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Topic · Pharmacology

Berberine and alkaloids research

Berberine and alkaloids research is a research topic within Pharmacology. Science Explorer counts 9.8k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the therapeutic potential of berberine alkaloids, particularly in the context of metabolic disorders such as diabetes mellitus. The research covers various aspects including the mechanisms of action, anti-inflammatory effects, cholesterol-lowering properties, and potential anticancer activities. Additionally, it explores the traditional use of berberine in Chinese medicine and its impact on glucose metabolism.

  • Berberine
  • Alkaloids
  • Metabolic Effects
  • Diabetes Mellitus
  • Anti-inflammatory
  • AMP-Activated Protein Kinase
  • Cholesterol-lowering
  • Anticancer
  • Glucose Metabolism
  • Traditional Medicine
Research works
9.8k
fractional, since 1950
In the world top 10%
982
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+35%
the tick is no change
Largest producer
China
59% of the 10 largest, 2022-now
Berberine and alkaloids research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Berberine and alkaloids research research?

By volume, China and India publish the most (1.3k and 349 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.3k works
  2. 2 India 349 works
  3. 3 United States 169 works
  4. 4 Iran 110 works
  5. 5 Türkiye 55 works
  6. 6 South Korea 50 works
  7. 7 Egypt 50 works
  8. 8 Saudi Arabia 47 works
  9. 9 Pakistan 45 works
  10. 10 Indonesia 42 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 59.1%India: 15.6%United States: 7.5%Iran: 4.9%6 others listed: 12.9%59%largest
China1,324 · 59.1%India349 · 15.6%United States169 · 7.5%Iran110 · 4.9%6 others listed289 · 12.9%

Shares of the rows listed above, not of the whole node.

Which institutions lead Berberine and alkaloids research research?

By volume in 2022-now, Chengdu University of Traditional Chinese Medicine publishes the most Berberine and alkaloids research research, followed by Chinese Academy of Medical Sciences & Peking Union Medical College and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Chengdu University of Traditional Chinese MedicineChina 45 works
  2. 2 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 35 works
  3. 3 Chinese Academy of SciencesChina 32 works
  4. 4 Guangzhou University of Chinese MedicineChina 27 works
  5. 5 Shanghai University of Traditional Chinese MedicineChina 25 works
  6. 6 Beijing University of Chinese MedicineChina 24 works
  7. 7 Tianjin University of Traditional Chinese MedicineChina 23 works
  8. 8 China Pharmaceutical UniversityChina 21 works
  9. 9 Nanjing University of Chinese MedicineChina 21 works
  10. 10 Zhejiang Chinese Medical UniversityChina 17 works

Who are the leading researchers in Berberine and alkaloids research?

The most-cited researchers publishing on Berberine and alkaloids research include Jun Wang, Reza Malekzadeh and Amirhossein Sahebkar.

  1. 1 Jun Wang China 340k citations
  2. 2 Reza Malekzadeh Iran 278k citations
  3. 3 Amirhossein Sahebkar Iran 258k citations
  4. 4 Huanming Yang China 246k citations
  5. 5 Hua Zhang Singapore 196k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Berberine and alkaloids research?

The most cited paper in Berberine and alkaloids research is "Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy" (Ta-Chung Yu, Fangfang Guo, Yanan Yu et al., 2017), with 2,275 citations. Next come "Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins" (1,394) and "Chelerythrine is a potent and specific inhibitor of protein kinase C" (1,210).

Most cited papers
#PaperReleasedCitations
1 Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy Ta-Chung Yu, Fangfang Guo, Yanan Yu et al. · Cell Open access Jul 2017 2,275
2 Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins Weijia Kong, Jing Wei, Parveen Abidi et al. · Nature Medicine 7 Nov 2004 1,394
3 Chelerythrine is a potent and specific inhibitor of protein kinase C Jean‐Marc Herbert, Jean‐Michel Augereau, J. Gleye et al. · Biochemical and Biophysical Research Communications Nov 1990 1,210
4 Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics Jack D. Scott, Robert M. Williams · Chemical Reviews Review 18 Apr 2002 1,148
5 Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice Amit S. Choudhari, Pallavi C. Mandave, Manasi Deshpande et al. · Frontiers in Pharmacology Open access 28 Jan 2020 1,087
All 100 most cited papers, with filters and sorting

Where is Berberine and alkaloids research research done?

The largest centres of Berberine and alkaloids research research in 2022-now are Beijing (China), Chengdu (China), Guangzhou (China) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Kunming.

Largest cities, 2022-now

  1. 1 BeijingChina 158 works
  2. 2 ChengduChina 80 works
  3. 3 GuangzhouChina 79 works
  4. 4 ShanghaiChina 68 works
  5. 5 NanjingChina 64 works
  6. 6 HangzhouChina 46 works
  7. 7 TianjinChina 40 works
  8. 8 WuhanChina 40 works
  9. 9 TehranIran 38 works
  10. 10 ChangshaChina 37 works

Where it is the local speciality

  1. KunmingCN · 33.2 works5.6×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Berberine and alkaloids research than the world average.

See Berberine and alkaloids research on the map

Where is the best place to study Berberine and alkaloids research?

Among universities, judged by research, Chengdu University of Traditional Chinese Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College and Mashhad University of Medical Sciences score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 16.73%fractional works in this field (log) →share of work in the world top 10% →Mashhad University o…Chengdu University o…Chinese Academy of M…Guangzhou University…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Chengdu University of Traditional Chinese MedicineChina 81.019.5%71.9×45 +88.2%
2Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 66.217.2%13.5×35 +4.5%
3Mashhad University of Medical SciencesIran 64.721.2%15.7×9 +24.6%
4Guangzhou University of Chinese MedicineChina 63.413.2%45.3×27 +50.9%
5Beijing University of Chinese MedicineChina 62.117.1%41.3×24 +10.2%
6Shandong University of Traditional Chinese MedicineChina 57.524.0%33.4×10 +128.3%
7Shanghai University of Traditional Chinese MedicineChina 57.112.3%37.9×25 +94.6%
8Nanjing University of Chinese MedicineChina 56.914.7%33.3×21 +120.7%
9Heilongjiang University of Chinese MedicineChina 56.816.6%69.7×15 +112.3%
10Tianjin University of Traditional Chinese MedicineChina 56.011.5%62.5×23 +30.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Berberine and alkaloids research, country by country

Is Berberine and alkaloids research research growing?

Output in 2022-2025 was 35% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Berberine and alkaloids research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Berberine and alkaloids research as a percentage of every work published that year, 0.0096% in 2024.

still counting0.0050%0.010%0.015%Berberine and alkaloids research0.013% in 202519801990200020102020

Fractional works of Berberine and alkaloids research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Berberine and alkaloids research9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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