Most cited papers in Inflammatory mediators and NSAID effects
What are the most cited papers in Inflammatory mediators and NSAID effects?
The most cited paper in Inflammatory mediators and NSAID effects is "The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine" (Robert F. Furchgott, John V. Zawadzki, 1980), with 12,123 citations. Next come "Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs" (8,642) and "In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation" (4,236).
Showing 50 of 100 papers. Every paper with more than 1,221 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature | Nov 1980 | 12,123 |
| 2 | Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs John Robert Vane · Nature New Biology | Jun 1971 | 8,642 |
| 3 | In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation Calamita, Elisa, Schmid, Martin, Kunz, Manuel et al. · Figshare | Nov 2019 | 4,236 |
| 4 | Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis Claire Bombardier, Loren Laine, Alise S. Reicin et al. · New England Journal of Medicine | 23 Nov 2000 | 4,053 |
| 5 | Prostaglandins and Inflammation Emanuela Ricciotti, Garret A. FitzGerald · Arteriosclerosis Thrombosis and Vascular Biology | 20 Apr 2011 | 3,833 |
| 6 | Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology Colin D. Funk · Science | 30 Nov 2001 | 3,829 |
| 7 | An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Salvador Moncada, Ryszard Jerzy Gryglewski, S Bunting et al. · Nature | Oct 1976 | 3,608 |
| 8 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Mats Hámberg, Jan Olof Svensson, Bengt Samuelsson · Proceedings of the National Academy of Sciences | Aug 1975 | 3,065 |
| 9 | Cyclooxygenases: Structural, Cellular, and Molecular Biology William Lee Smith, David L. DeWitt, R. Michael Garavito · Annual Review of Biochemistry | Jun 2000 | 2,933 |
| 10 | PPAR-γ agonists inhibit production of monocyte inflammatory cytokines Chengyu Jiang, Adrian T. Ting, Brian Seed · Nature | 1998 | 2,909 |
| 11 | Role of proinflammatory cytokines in the pathophysiology of osteoarthritis Mohit Kapoor, Johanne Martel‐Pelletier, Daniel Lajeunesse et al. · Nature Reviews Rheumatology | 30 Nov 2010 | 2,805 |
| 12 | The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen Andrew K. Shiau, Danielle Barstad, Paula M. Loria et al. · Cell | Dec 1998 | 2,750 |
| 13 | CYCLOOXYGENASES 1 AND 2 John Robert Vane, Y.S. Bakhle, Renia M. Botting · The Annual Review of Pharmacology and Toxicology | Apr 1998 | 2,744 |
| 14 | The pharmacological basis of therapeutics Arthur L. Frank · Environmental Research | Apr 1981 | 2,737 |
| 15 | The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis Gideon Steinbach et al. · New England Journal of Medicine | 29 Jun 2000 | 2,539 |
| 16 | Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas Charles E. Eberhart, R J Coffey, Radhika Aramandla et al. · Gastroenterology | Oct 1994 | 2,536 |
| 17 | Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial Robert S. Bresalier, Robert S. Sandler, Hui Quan et al. · New England Journal of Medicine | 16 Feb 2005 | 2,530 |
| 18 | Cyclooxygenase in biology and disease Raymond N. DuBois, Steven B. Abramson, Leslie J. Crofford et al. · The FASEB Journal | Sep 1998 | 2,519 |
| 19 | Prostanoid Receptors: Structures, Properties, and Functions Shuh Narumiya, Yukihiko Sugimoto, Fumitaka Ushikubi · Physiological Reviews | 10 Jan 1999 | 2,419 |
| 20 | Role of angiogenesis in tumor growth and metastasis J Folkman · Seminars in Oncology | 16 Dec 2002 | 2,412 |
| 21 | Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2) Masanobu Oshima, Joseph E. Dinchuk, Stacia Kargman et al. · Cell | Nov 1996 | 2,374 |
| 22 | Osteoarthritis: an update with relevance for clinical practice J. W. J. Bijlsma, Françis Berenbaum, Floris P. J. G. Lafeber · The Lancet | Jun 2011 | 2,327 |
| 23 | Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells Masahiko Tsujii, Sunao Kawano, Shingo Tsuji et al. · Cell | May 1998 | 2,293 |
| 24 | Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2 Masahiko Tsujii, Raymond N. DuBois · Cell | Nov 1995 | 2,291 |
| 25 | Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product Malgorzata Katarzyna Kowalska, Magdalena Woźniak, Michał Kijek et al. · Scientific Reports | 6 Jan 2022 | 2,120 |
| 26 | Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention Scott David Solomon, John J.V. McMurray, Marc Alan Pfeffer et al. · New England Journal of Medicine | 16 Feb 2005 | 2,059 |
| 27 | A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation Steven A. Kliewer, James M. Lenhard, Timothy Mark Willson et al. · Cell | Dec 1995 | 2,035 |
| 28 | Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2 William Lee Smith, R. Michael Garavito, David L. DeWitt · Journal of Biological Chemistry | Dec 1996 | 1,999 |
| 29 | COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression Naduviladath Vishvanath Chandrasekharan, Hu Dai, Katarina Roos et al. · Proceedings of the National Academy of Sciences | 19 Sep 2002 | 1,990 |
| 30 | Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Christopher G. Willett et al. · Nature Medicine | 25 Jan 2004 | 1,968 |
| 31 | Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ Robert T. Nolte, G. Bruce Wisely, Stefan K. Westin et al. · Nature | Sep 1998 | 1,965 |
| 32 | Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs M. Michael Wolfe, David R. Lichtenstein, Gurkirpal Singh · New England Journal of Medicine | 17 Jun 1999 | 1,963 |
| 33 | A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women Paul M. Ridker, Nancy R. Cook, I‐Min Lee et al. · New England Journal of Medicine | 7 Mar 2005 | 1,962 |
| 34 | Guide to Receptors and Channels (GRAC), 5th edition SPH Alexander, Alistair A. Mathie, JA Peters · British Journal of Pharmacology | Nov 2011 | 1,944 |
| 35 | Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective Samik Bindu, Somnath Mazumder, Uday Bandyopadhyay · Biochemical Pharmacology | 9 Jul 2020 | 1,935 |
| 36 | Osteoarthritis Johanne Martel‐Pelletier, Andrew Barr, Flavia Cicuttini et al. · Nature Reviews Disease Primers | 13 Oct 2016 | 1,933 |
| 37 | Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature | 26 Dec 1996 | 1,922 |
| 38 | A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Jason D. Morrow, Kristina E. Hill, Raymond F. Burk et al. · Proceedings of the National Academy of Sciences | Dec 1990 | 1,906 |
| 39 | Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials N Bhala · The Lancet | 29 May 2013 | 1,809 |
| 40 | Eicosanoids and cancer Dingzhi Wang, Raymond N. DuBois · Nature reviews. Cancer | 19 Feb 2010 | 1,802 |
| 41 | Chronic Inflammation and Cytokines in the Tumor Microenvironment Glauben Landskron, Marjorie De la Fuente, Peti Thuwajit et al. · Journal of Immunology Research | 2014 | 1,794 |
| 42 | Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors Debabrata Mukherjee · JAMA | 22 Aug 2001 | 1,756 |
| 43 | International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Robert A. Coleman, William Lee Smith, Shuh Narumiya · Pharmacological Reviews | Jun 1994 | 1,750 |
| 44 | Tumor angiogenesis: molecular pathways and therapeutic targets Sara M. Weis, David A. Cheresh · Nature Medicine | Nov 2011 | 1,748 |
| 45 | Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) Françis Berenbaum · Osteoarthritis and Cartilage | 26 Nov 2012 | 1,738 |
| 46 | Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis Francis M. Giardiello, Stanley R. Hamilton, Anne J. Krush et al. · New England Journal of Medicine | 6 May 1993 | 1,731 |
| 47 | Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences | Apr 1991 | 1,717 |
| 48 | IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation | May 1999 | 1,703 |
| 49 | Cytoprotection by prostaglandins in rats André Robert, James E. Nezamis, C. Roy D. Lancaster et al. · Gastroenterology | Sep 1979 | 1,698 |
| 50 | Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition Daniel L. Simmons, Regina M. Botting, Timothy Hla · Pharmacological Reviews | 18 Aug 2004 | 1,694 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.