Topic · Autophagy in Disease and Therapy
Most cited papers in Autophagy in Disease and Therapy
What are the most cited papers in Autophagy in Disease and Therapy?
The most cited paper in Autophagy in Disease and Therapy is "Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death" (Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al., 2012), with 19,018 citations. Next come "Repertoires of Autophagy in the Pathogenesis of Ocular Diseases" (16,339) and "Apoptosis: A Review of Programmed Cell Death" (13,911).
Showing 50 of 100 papers. Every paper with more than 2,275 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell | May 2012 | 19,018 |
| 2 | Repertoires of Autophagy in the Pathogenesis of Ocular Diseases Yujie Li, Qin Li Jiang, Guo-Fan Cao et al. · Cellular Physiology and Biochemistry | 2015 | 16,339 |
| 3 | Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology | Jun 2007 | 13,911 |
| 4 | The biochemistry of apoptosis Michael Otmar Hengartner · Nature | Oct 2000 | 7,357 |
| 5 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology | 23 Jan 2011 | 7,286 |
| 6 | Autophagy in the Pathogenesis of Disease Beth Levine, Guido Kroemer · Cell | 2008 | 7,137 |
| 7 | Caspases: Enemies Within Nancy A. Thornberry, Yuri A. Lazebnik · Science | 28 Aug 1998 | 6,945 |
| 8 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 Lorenzo Galluzzi et al. · Cell Death and Differentiation | 23 Jan 2018 | 6,760 |
| 9 | LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing Yukihiro Kabeya, Noboru Mizushima, Takashi Ueno et al. · The EMBO Journal | Nov 2000 | 6,650 |
| 10 | Apoptosis in the Pathogenesis and Treatment of Disease Craig B. Thompson · Science | 10 Mar 1995 | 6,597 |
| 11 | Autophagy: Renovation of Cells and Tissues Noboru Mizushima, Masaaki Komatsu · Cell | Nov 2011 | 6,527 |
| 12 | Autophagy fights disease through cellular self-digestion Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature | Feb 2008 | 6,507 |
| 13 | Signal integration in the endoplasmic reticulum unfolded protein response David Ron, Peter Walter · Nature Reviews Molecular Cell Biology | 14 Jun 2007 | 6,391 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Daniel J. Klionsky et al. · Autophagy | 2 Jan 2016 | 6,023 |
| 15 | A role for mitochondria in NLRP3 inflammasome activation Rongbin Zhou, Amir Sadegh Yazdi, Philippe Menu et al. · Nature | Dec 2010 | 5,609 |
| 16 | Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c Xuesong Liu, Caryn Naekyung Kim, Jie Yang et al. · Cell | Jul 1996 | 5,207 |
| 17 | Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury. Changmeng Cui, Jianzhong Cui, Feng Jin et al. · PubMed | 2017 | 5,190 |
| 18 | Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy Stefano De Cillà, Serena Farruggio, Stela Vujosevic et al. · Cellular Physiology and Biochemistry | 2017 | 5,140 |
| 19 | The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis Ruth M. Kluck, Ella Bossy‐Wetzel, Douglas R. Green et al. · Science | 21 Feb 1997 | 4,758 |
| 20 | Cell Death Nika N. Danial, Stanley J. Korsmeyer · Cell | 2004 | 4,675 |
| 21 | p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry | 19 Jun 2007 | 4,649 |
| 22 | Methods in Mammalian Autophagy Research Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell | Feb 2010 | 4,567 |
| 23 | Autophagy and Viruses: Adversaries or Allies? Xiaonan Dong, Beth Levine · Journal of Innate Immunity | 2013 | 4,442 |
| 24 | The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction Michael H. Glickman, Aaron J. Ciechanover · Physiological Reviews | Apr 2002 | 4,266 |
| 25 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond Claudio A. Hetz · Nature Reviews Molecular Cell Biology | 18 Jan 2012 | 4,252 |
| 26 | AMPK: guardian of metabolism and mitochondrial homeostasis Sébastien Herzig, Reuben J. Shaw · Nature Reviews Molecular Cell Biology | 4 Oct 2017 | 4,189 |
| 27 | Parkin is recruited selectively to impaired mitochondria and promotes their autophagy Derek P. Narendra, Atsushi Tanaka, Der‐Fen Suen et al. · The Journal of Cell Biology | 24 Nov 2008 | 4,074 |
| 28 | Guidelines for the use and interpretation of assays for monitoring autophagy Daniel J. Klionsky et al. · Autophagy | Apr 2012 | 4,068 |
| 29 | Autophagy regulates lipid metabolism Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature | Apr 2009 | 4,022 |
| 30 | Autophagy: process and function Noboru Mizushima · Genes & Development | 15 Nov 2007 | 4,008 |
| 31 | Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science | 27 Apr 2001 | 3,999 |
| 32 | Emerging roles of caspase-3 in apoptosis Alan George Porter, Reiner U. Jänicke · Cell Death and Differentiation | 28 Jan 1999 | 3,932 |
| 33 | Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Taichi Hara, Kenji D. Nakamura, Makoto Matsui et al. · Nature | 19 Apr 2006 | 3,905 |
| 34 | Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Umut Özcan, Qiong Cao, Erkan Yılmaz et al. · Science | 14 Oct 2004 | 3,878 |
| 35 | Autophagy: cellular and molecular mechanisms D.R. Glick, Sandra Barth, Kay F. Macleod · The Journal of Pathology | 3 Feb 2010 | 3,845 |
| 36 | Activation of apoptosis signalling pathways by reactive oxygen species Maureen Redza-Dutordoir, Diana A. Averill‐Bates · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 17 Sep 2016 | 3,794 |
| 37 | The Ubiquitin Code David Komander, Michael Rapé · Annual Review of Biochemistry | 22 May 2012 | 3,767 |
| 38 | Mitochondrial Fission, Fusion, and Stress Richard J. Youle, Alexander M. van der Bliek · Science | 30 Aug 2012 | 3,720 |
| 39 | Development by Self-Digestion Beth Levine, Daniel J. Klionsky · Developmental Cell | Apr 2004 | 3,681 |
| 40 | Self-eating and self-killing: crosstalk between autophagy and apoptosis Maria Chiara Maiuri, Einat Zalckvar, Adi Kimchi et al. · Nature Reviews Molecular Cell Biology | 23 Aug 2007 | 3,659 |
| 41 | Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors Xu Luo, I. Imawati Budihardjo, Hua Zou et al. · Cell | Aug 1998 | 3,659 |
| 42 | Autophagy as a Regulated Pathway of Cellular Degradation Daniel J. Klionsky, Scott D. Emr · Science | Dec 2000 | 3,633 |
| 43 | Regulation Mechanisms and Signaling Pathways of Autophagy Congcong He, Daniel J. Klionsky · Annual Review of Genetics | 4 Aug 2009 | 3,612 |
| 44 | Autophagy and the Integrated Stress Response Guido Kroemer, Guillermo Mariño, Beth Levine · Molecular Cell | Oct 2010 | 3,556 |
| 45 | Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila Ryan H. Moy, Sara R. Cherry · Journal of Innate Immunity | 2013 | 3,551 |
| 46 | Mitochondria: In Sickness and in Health Jodi M. Nunnari, Anu Suomalainen · Cell | Mar 2012 | 3,549 |
| 47 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy Sophie Pattingre, Amina Tassa, Xueping Qu et al. · Cell | Sep 2005 | 3,541 |
| 48 | Loss of autophagy in the central nervous system causes neurodegeneration in mice Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba et al. · Nature | 19 Apr 2006 | 3,523 |
| 49 | Ageing as a risk factor for neurodegenerative disease Yujun Hou, Xiuli Dan, Mansi Babbar et al. · Nature Reviews Neurology | 9 Sep 2019 | 3,412 |
| 50 | TFEB Links Autophagy to Lysosomal Biogenesis Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito et al. · Science | 26 May 2011 | 3,389 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.