Autophagy in Disease and Therapy

Autophagy in Disease and Therapy is a research topic within Epidemiology. Science Explorer counts 32k research works in it since 1956. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of autophagy in various diseases, including neurodegenerative diseases, cancer, and infections. It covers the molecular mechanisms, regulation, and therapeutic implications of autophagy, as well as its interactions with apoptosis, inflammation, and immunity.

Autophagy
Disease
Cellular Self-Digestion
Mitophagy
Apoptosis
Lysosomal Biogenesis
Parkinson's Disease
Cancer
Inflammation
Immunity

Research works: 32k
In the world top 10%: 3.1k
Top-10% rate: 9.9%
Growth, 2018-21 → 2022-25: +4%
Largest producer: China

Autophagy in Disease and Therapy

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Autophagy in Disease and Therapy research?

By volume, China and the United States publish the most (4.9k and 1.3k works in 2022-now).

By volume, 2022-now

1 China 4.9k works
2 United States 1.3k works
3 India 370 works
4 Japan 313 works
5 South Korea 302 works
6 Italy 219 works
7 Germany 218 works
8 United Kingdom 192 works
9 France 160 works
10 Iran 149 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China4,920 · 60.5%United States1,291 · 15.9%India370 · 4.6%Japan313 · 3.9%6 others listed1,240 · 15.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Autophagy in Disease and Therapy research?

By volume in 2022-now, Zhejiang University publishes the most Autophagy in Disease and Therapy research, followed by Sun Yat-sen University and Nanjing Medical University.

By volume, 2022-now

1 Zhejiang UniversityChina 104 works
2 Sun Yat-sen UniversityChina 97 works
3 Nanjing Medical UniversityChina 95 works
4 Shanghai Jiao Tong UniversityChina 92 works
5 Chinese Academy of SciencesChina 86 works
6 Sichuan UniversityChina 79 works
7 Central South UniversityChina 75 works
8 Southern Medical UniversityChina 71 works
9 Wuhan UniversityChina 70 works
10 Fudan UniversityChina 70 works

Who are the leading researchers in Autophagy in Disease and Therapy?

The most-cited researchers publishing on Autophagy in Disease and Therapy include Mark J. Daly, Guido Kroemer and Hermann Brenner.

1 Mark J. Daly United States 403k citations
2 Guido Kroemer France 386k citations
3 Hermann Brenner Germany 343k citations
4 Shizuo Akira Japan 342k citations
5 Jun Wang China 340k citations
6 Giuseppe Remuzzi Italy 328k citations
7 Gregory Y.H. Lip United Kingdom 311k citations
8 Matthias Mann Germany 308k citations
9 John Q. Trojanowski United States 286k citations
10 Todd R. Golub United States 283k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Autophagy in Disease and Therapy?

The most cited paper in Autophagy in Disease and Therapy is "Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death" (Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al., 2012), with 19,018 citations. Next come "Repertoires of Autophagy in the Pathogenesis of Ocular Diseases" (16,339) and "Apoptosis: A Review of Programmed Cell Death" (13,911).

Most cited papers
#	Paper	Released	Citations
1	Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell Open access	May 2012	19,018
2	Repertoires of Autophagy in the Pathogenesis of Ocular Diseases Yujie Li, Qin Li Jiang, Guo-Fan Cao et al. · Cellular Physiology and Biochemistry Open access	2015	16,339
3	Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology Open access	Jun 2007	13,911
4	The biochemistry of apoptosis Michael Otmar Hengartner · Nature	Oct 2000	7,357
5	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology Open access	23 Jan 2011	7,286

All 100 most cited papers, with filters and sorting

Where is Autophagy in Disease and Therapy research done?

The largest centres of Autophagy in Disease and Therapy research in 2022-now are Beijing (China), Guangzhou (China), Shanghai (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Zunyi, Luzhou and Hengyang.

Largest cities, 2022-now

1 BeijingChina 448 works
2 GuangzhouChina 351 works
3 ShanghaiChina 330 works
4 NanjingChina 224 works
5 HangzhouChina 212 works
6 WuhanChina 200 works
7 ChengduChina 152 works
8 ChangshaChina 147 works
9 ChongqingChina 139 works
10 JinanChina 131 works

Where it is the local speciality

ZunyiCN · 24.0 works12×
LuzhouCN · 28.5 works12×
HengyangCN · 31.6 works9.5×
WenzhouCN · 63.0 works7.7×

← less than its size predicts1×more →

Location quotient: how much more of its research is in Autophagy in Disease and Therapy than the world average.

See Autophagy in Disease and Therapy on the map

Where is the best place to study Autophagy in Disease and Therapy?

Among universities, judged by research, Sichuan University, Zhejiang University and Sun Yat-sen University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged

40%

Specialisationhow much of its work is in this field, counted up to 10× the world share

10%

Sizeits output in this field, on a log scale

30%

Growthoutput growth, counted from -20% to +20%

10%

Internationalshare of its work with a co-author abroad

10%

Each slider sets a weight; the share it gets of the score is beside it.

#	University	Score	Top 10%	Specialisation	Works	Growth
1	Sichuan UniversityChina	65.1	16.3%	4.2×	79	+6.4%
2	Zhejiang UniversityChina	64.2	12.0%	4.7×	104	+8.3%
3	Sun Yat-sen UniversityChina	64.0	12.8%	5.7×	97	+5.6%
4	Nanjing Medical UniversityChina	63.6	9.9%	13.0×	96	+21.4%
5	Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina	63.1	13.7%	7.4×	64	+17.0%
6	Chengdu University of Traditional Chinese MedicineChina	62.9	17.3%	13.9×	29	+218.9%
7	University of MacauChina	61.4	16.6%	5.3×	14	+32.2%
8	Huazhong University of Science and TechnologyChina	60.8	14.0%	4.5×	67	+9.4%
9	Harvard UniversityUnited States	60.8	16.8%	1.6×	43	-23.4%
10	University of DundeeUnited Kingdom	60.0	12.4%	8.4×	12	+29.4%
11	Central South UniversityChina	59.0	13.9%	4.7×	75	-8.3%
12	Jinan UniversityChina	59.0	15.7%	6.6×	30	+40.5%
13	Southern Medical UniversityChina	58.9	10.4%	13.9×	71	+8.6%
14	Guangzhou Medical UniversityChina	57.9	12.4%	12.5×	38	+42.8%
15	Wuhan UniversityChina	57.6	13.4%	6.0×	70	-2.6%
16	Nanchang UniversityChina	57.3	8.6%	9.9×	61	+50.5%
17	Fudan UniversityChina	57.1	12.9%	5.3×	70	-6.4%
18	Shanghai University of Traditional Chinese MedicineChina	54.3	11.7%	15.5×	35	+44.9%
19	Guangdong Medical CollegeChina	54.2	15.8%	21.1×	19	+55.5%
20	Medical University of ViennaAustria	53.7	21.4%	3.4×	9	+59.3%
21	Shanghai Jiao Tong UniversityChina	53.6	12.1%	3.9×	92	-21.2%
22	KU LeuvenBelgium	53.6	23.0%	1.3×	10	-10.6%
23	Guangzhou University of Chinese MedicineChina	53.4	10.1%	18.6×	37	+71.7%
24	China Medical UniversityChina	52.9	14.5%	16.8×	58	-24.7%
25	Nantong UniversityChina	52.2	11.5%	8.5×	32	+56.1%
26	Fujian Medical UniversityChina	51.7	7.9%	11.2×	51	+77.5%
27	Northeast Agricultural UniversityChina	51.6	14.5%	7.5×	16	+122.5%
28	University of PennsylvaniaUnited States	51.5	16.9%	2.0×	18	-7.8%
29	University of OsloNorway	51.4	17.1%	3.2×	17	-8.4%
30	Wenzhou Medical UniversityChina	51.2	9.3%	13.7×	57	+0.6%
31	Tongji UniversityChina	51.2	12.2%	2.7×	35	+15.2%
32	Nanjing University of Chinese MedicineChina	51.0	10.1%	14.5×	30	+75.5%
33	Anhui Medical UniversityChina	50.9	7.2%	13.1×	50	+34.8%
34	Qingdao UniversityChina	50.9	10.6%	7.7×	43	+5.7%
35	Northwestern UniversityUnited States	50.9	21.8%	1.7×	12	+5.7%
36	Beijing University of Chinese MedicineChina	50.8	10.8%	14.2×	28	+54.8%
37	University of California, San FranciscoUnited States	50.6	18.6%	2.2×	13	-35.7%
38	University of South ChinaChina	50.4	10.6%	13.7×	30	+37.7%
39	Chongqing Medical UniversityChina	50.1	7.1%	13.7×	64	-0.7%
40	Zhengzhou UniversityChina	49.3	9.6%	5.5×	55	+2.9%
41	Rutgers, The State University of New JerseyUnited States	48.1	15.5%	2.5×	16	-21.0%
42	University of California, BerkeleyUnited States	47.1	18.9%	1.3×	10	-11.9%
43	Cornell UniversityUnited States	46.1	20.2%	1.5×	16	-28.3%
44	New York UniversityUnited States	42.6	21.8%	1.0×	9	-37.4%
45	University of OxfordUnited Kingdom	42.2	17.5%	0.9×	10	-11.7%
46	Karolinska InstitutetSweden	42.1	14.1%	2.9×	14	-30.7%
47	University College LondonUnited Kingdom	42.0	13.1%	1.1×	15	-8.7%
48	National University of SingaporeSingapore	41.5	21.1%	1.2×	12	-43.6%
49	Columbia UniversityUnited States	41.5	18.9%	1.1×	10	-28.7%
50	University of Hong KongChina	40.8	16.8%	1.6×	12	-24.2%
51	Chinese University of Hong KongChina	40.2	11.4%	2.1×	13	-5.6%
52	University of GroningenNetherlands	35.5	17.4%	1.6×	9	-38.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Autophagy in Disease and Therapy, country by country

Is Autophagy in Disease and Therapy research growing?

Output in 2022-2025 was 4% higher than in 2018-2021, peaking in 2022. The fastest-growing topics are Autophagy in Disease and Therapy.

grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Autophagy in Disease and Therapy as a percentage of every work published that year, 0.037% in 2024.

Fractional works of Autophagy in Disease and Therapy over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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Which countries lead Autophagy in Disease and Therapy research?

By volume, 2022-now

How concentrated that is

Which institutions lead Autophagy in Disease and Therapy research?

By volume, 2022-now

Who are the leading researchers in Autophagy in Disease and Therapy?

What are the most cited papers in Autophagy in Disease and Therapy?

Where is Autophagy in Disease and Therapy research done?

Largest cities, 2022-now

Where it is the local speciality

Where is the best place to study Autophagy in Disease and Therapy?

Is Autophagy in Disease and Therapy research growing?

Its share of all research

How much of it reaches the world top 10%

Which topics inside it are moving

Related research

Discussion