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Topic · Epidemiology

Sepsis Diagnosis and Treatment

Sepsis Diagnosis and Treatment is a research topic within Epidemiology. Science Explorer counts 54k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the epidemiology, diagnosis, management, and prognosis of sepsis and septic shock. It covers topics such as the definition of sepsis, assessment of clinical criteria, evaluation of prediction models, use of biomarkers, antimicrobial therapy, and the impact of various factors on patient outcomes in critical care settings.

  • Sepsis
  • Septic Shock
  • Epidemiology
  • Management
  • Prognostic Models
  • Infection
  • Critical Care
  • Biomarkers
  • Antimicrobial Therapy
  • Microcirculation
Research works
54k
fractional, since 1950
In the world top 10%
5.4k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+20%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Sepsis Diagnosis and Treatment

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Sepsis Diagnosis and Treatment research?

By volume, the United States and China publish the most (3.5k and 3.1k works in 2022-now).

By volume, 2022-now

  1. 1 United States 3.5k works
  2. 2 China 3.1k works
  3. 3 India 788 works
  4. 4 United Kingdom 684 works
  5. 5 Germany 509 works
  6. 6 Türkiye 440 works
  7. 7 Japan 439 works
  8. 8 France 412 works
  9. 9 Australia 412 works
  10. 10 Italy 399 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 33.0%China: 28.9%India: 7.4%United Kingdom: 6.4%6 others listed: 24.4%33%largest
United States3,526 · 33.0%China3,091 · 28.9%India788 · 7.4%United Kingdom684 · 6.4%6 others listed2,612 · 24.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Sepsis Diagnosis and Treatment research?

By volume in 2022-now, Harvard University publishes the most Sepsis Diagnosis and Treatment research, followed by Capital Medical University and Sichuan University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 150 works
  2. 2 Capital Medical UniversityChina 111 works
  3. 3 Sichuan UniversityChina 93 works
  4. 4 Mayo ClinicUnited States 89 works
  5. 5 Shanghai Jiao Tong UniversityChina 80 works
  6. 6 Zhejiang UniversityChina 76 works
  7. 7 University of TorontoCanada 74 works
  8. 8 University of MichiganUnited States 73 works
  9. 9 All India Institute of Medical SciencesIndia 69 works
  10. 10 InsermFrance 68 works

Who are the leading researchers in Sepsis Diagnosis and Treatment?

The most-cited researchers publishing on Sepsis Diagnosis and Treatment include David Moher, Douglas G. Altman and Christopher J L Murray.

  1. 1 David Moher Canada 898k citations
  2. 2 Douglas G. Altman United Kingdom 862k citations
  3. 3 Christopher J L Murray United States 583k citations
  4. 4 Simon Iain Hay United States 452k citations
  5. 5 George Davey Smith United Kingdom 435k citations
  6. 6 Ali H. Mokdad United States 429k citations
  7. 7 Zulfiqar Ahmed Bhutta Pakistan 371k citations
  8. 8 John J.V. McMurray United Kingdom 349k citations
  9. 9 Hermann Brenner Germany 343k citations
  10. 10 Shizuo Akira Japan 342k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Sepsis Diagnosis and Treatment?

The most cited paper in Sepsis Diagnosis and Treatment is "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)" (Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al., 2016), with 29,012 citations. Next come "pROC: an open-source package for R and S+ to analyze and compare ROC curves" (14,550) and "APACHE II" (13,863).

Most cited papers
#PaperReleasedCitations
1 The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA Open access 22 Feb 2016 29,012
2 pROC: an open-source package for R and S+ to analyze and compare ROC curves Xavier Robin, Natacha Turck, Alexandre Hainard et al. · BMC Bioinformatics Open access 17 Mar 2011 14,550
3 APACHE II William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine Oct 1985 13,863
4 Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis Roger C. Bone, ROBERT A. BALK, Frank B. Cerra et al. · CHEST Journal Open access Jun 1992 13,306
5 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure Jean‐Louis Vincent, Rui Paulo Moreno, Jukka A. Takala et al. · Intensive Care Medicine Jul 1996 11,938
All 97 most cited papers, with filters and sorting

Where is Sepsis Diagnosis and Treatment research done?

The largest centres of Sepsis Diagnosis and Treatment research in 2022-now are Beijing (China), London (United Kingdom), Shanghai (China) and Guangzhou (China).

Largest cities, 2022-now

  1. 1 BeijingChina 392 works
  2. 2 LondonUnited Kingdom 209 works
  3. 3 ShanghaiChina 204 works
  4. 4 GuangzhouChina 203 works
  5. 5 SeoulSouth Korea 187 works
  6. 6 ParisFrance 160 works
  7. 7 BostonUnited States 152 works
  8. 8 ChengduChina 145 works
  9. 9 HangzhouChina 143 works
  10. 10 IstanbulTürkiye 132 works
See Sepsis Diagnosis and Treatment on the map

Where is the best place to study Sepsis Diagnosis and Treatment?

Among universities, judged by research, University of Amsterdam, Sichuan University and Harvard University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.19%fractional works in this field (log) →share of work in the world top 10% →University of Amster…Sichuan UniversityUniversity of TorontoHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University of AmsterdamNetherlands 67.222.7%3.2×27 +38.1%
2Sichuan UniversityChina 66.416.3%3.0×93 +129.0%
3Harvard UniversityUnited States 66.313.5%3.4×150 -14.1%
4University of TorontoCanada 65.814.5%2.7×74 +8.7%
5Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 63.815.8%4.6×66 +97.5%
6Zhejiang UniversityChina 62.716.2%2.0×76 +50.2%
7Capital Medical UniversityChina 62.410.5%7.6×111 +78.3%
8Australian and New Zealand Intensive Care SocietyAustralia 60.520.1%101.4×8 +52.2%
9University of CopenhagenDenmark 60.212.1%3.6×47 +33.4%
10University of California, San FranciscoUnited States 60.220.2%4.0×39 -6.1%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Sepsis Diagnosis and Treatment, country by country

Is Sepsis Diagnosis and Treatment research growing?

Output in 2022-2025 was 20% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Sepsis Diagnosis and Treatment.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Sepsis Diagnosis and Treatment as a percentage of every work published that year, 0.054% in 2024.

still counting0.025%0.050%0.075%Sepsis Diagnosis and Treatment0.070% in 202519801990200020102020

Fractional works of Sepsis Diagnosis and Treatment over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Sepsis Diagnosis and Treatment9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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