Topic · Sepsis Diagnosis and Treatment
Most cited papers in Sepsis Diagnosis and Treatment
What are the most cited papers in Sepsis Diagnosis and Treatment?
The most cited paper in Sepsis Diagnosis and Treatment is "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)" (Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al., 2016), with 29,012 citations. Next come "pROC: an open-source package for R and S+ to analyze and compare ROC curves" (14,550) and "APACHE II" (13,863).
Showing 50 of 97 papers. Every paper with more than 1,840 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA | 22 Feb 2016 | 29,012 |
| 2 | pROC: an open-source package for R and S+ to analyze and compare ROC curves Xavier Robin, Natacha Turck, Alexandre Hainard et al. · BMC Bioinformatics | 17 Mar 2011 | 14,550 |
| 3 | APACHE II William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine | Oct 1985 | 13,863 |
| 4 | Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis Roger C. Bone, ROBERT A. BALK, Frank B. Cerra et al. · CHEST Journal | Jun 1992 | 13,306 |
| 5 | The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure Jean‐Louis Vincent, Rui Paulo Moreno, Jukka A. Takala et al. · Intensive Care Medicine | Jul 1996 | 11,938 |
| 6 | Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock Emanuel P. Rivers, Bryant Nguyen, Suzanne L Havstad et al. · New England Journal of Medicine | 8 Nov 2001 | 10,842 |
| 7 | Intensive Insulin Therapy in Critically Ill Patients Greet Van den Berghe, Pieter Jozef Wouters, Frank Weekers et al. · New England Journal of Medicine | 8 Nov 2001 | 10,071 |
| 8 | Surviving Sepsis Campaign R. Phillip Dellinger et al. · Critical Care Medicine | 26 Jan 2013 | 9,769 |
| 9 | Acute Respiratory Distress Syndrome Ards Definition Task Force · JAMA | 20 May 2012 | 8,927 |
| 10 | Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Derek C. Angus, Walter T. Linde‐Zwirble, Jeffrey R. Lidicker et al. · Critical Care Medicine | Jul 2001 | 8,644 |
| 11 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study Kristina E. Rudd et al. · The Lancet | 2020 | 8,189 |
| 12 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012 Richard P. Dellinger et al. · Intensive Care Medicine | 29 Jan 2013 | 7,373 |
| 13 | Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus Peter A. Banks, Thomas L. Bollen, Christos Dervenis et al. · Gut | 25 Oct 2012 | 7,229 |
| 14 | Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group Rinaldo Bellomo, Claudio Ronco, John A. Kellum et al. · Critical Care | 22 May 2004 | 6,870 |
| 15 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 Andrew Rhodes et al. · Intensive Care Medicine | 18 Jan 2017 | 6,868 |
| 16 | Endothelial cell infection and endotheliitis in COVID-19 Zsuzsanna Varga, Andreas J. Flammer, Peter Steiger et al. · The Lancet | 21 Apr 2020 | 6,667 |
| 17 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine MARK H. ZWEIG, Gregory Campbell · Clinical Chemistry | Apr 1993 | 6,656 |
| 18 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study J. R. Le Gall · JAMA | 22 Dec 1993 | 6,370 |
| 19 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock* Anand Kumar, DANIEL E. ROBERTS, Kenneth E. Wood et al. · Critical Care Medicine | 19 Apr 2006 | 6,210 |
| 20 | Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine | 8 Mar 2001 | 6,170 |
| 21 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Mitchell M. Levy, Mitchell P. Fink, John C. Marshall et al. · Critical Care Medicine | Apr 2003 | 6,064 |
| 22 | Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries Giacomo Bellani, John Gerard Laffey, Tài Pham et al. · JAMA | 22 Feb 2016 | 6,014 |
| 23 | The Epidemiology of Sepsis in the United States from 1979 through 2000 Greg S. Martin, David M. Mannino, Stephanie Eaton et al. · New England Journal of Medicine | 16 Apr 2003 | 5,909 |
| 24 | Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Ning Tang, Dengju Li, Xiong Wang et al. · Journal of Thrombosis and Haemostasis | 19 Feb 2020 | 5,896 |
| 25 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Laura Evans et al. · Intensive Care Medicine | 2 Oct 2021 | 5,314 |
| 26 | A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care Paul C. Hébert, George A. Wells, Morris A. Blajchman et al. · New England Journal of Medicine | 11 Feb 1999 | 5,247 |
| 27 | Intensive versus Conventional Glucose Control in Critically Ill Patients Nice-Sugar Study Investigators · New England Journal of Medicine | 24 Mar 2009 | 5,153 |
| 28 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 R. Phillip Dellinger et al. · Intensive Care Medicine | 3 Dec 2007 | 4,947 |
| 29 | A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia Michael J. Fine, Thomas E. Auble, Donald M. Yealy et al. · New England Journal of Medicine | 23 Jan 1997 | 4,685 |
| 30 | Receiver Operating Characteristic Curve in Diagnostic Test Assessment Jayawant N. Mandrekar · Journal of Thoracic Oncology | 26 Aug 2010 | 4,681 |
| 31 | Acute Renal Failure in Critically Ill Patients A Multinational, Multicenter Study Shigehiko Uchino · JAMA | 16 Aug 2005 | 4,242 |
| 32 | The Pathophysiology and Treatment of Sepsis Richard S. Hotchkiss, Irene E. Karl · New England Journal of Medicine | 8 Jan 2003 | 4,137 |
| 33 | Severe Sepsis and Septic Shock Derek C. Angus, Tom van der Poll · New England Journal of Medicine | 28 Aug 2013 | 4,031 |
| 34 | Assessment of Clinical Criteria for Sepsis Christopher W. Seymour, Vincent X. Liu, Theodore John Iwashyna et al. · JAMA | 22 Feb 2016 | 3,936 |
| 35 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit Juliana Barr et al. · Critical Care Medicine | 24 Dec 2012 | 3,834 |
| 36 | Derivation and Prospective Validation of a Simple Index for Prediction of Cardiac Risk of Major Noncardiac Surgery Thomas Ho-yin Lee, Edward R. Marcantonio, Carol M. Mangione et al. · Circulation | 7 Sep 1999 | 3,798 |
| 37 | Incidence and Outcomes of Acute Lung Injury Gordon David Rubenfeld, Ellen Caldwell, E. H. Peabody et al. · New England Journal of Medicine | 20 Oct 2005 | 3,696 |
| 38 | International Study of the Prevalence and Outcomes of Infection in Intensive Care Units Jean‐Louis Vincent · JAMA | Dec 2009 | 3,682 |
| 39 | Assessment of Global Incidence and Mortality of Hospital-treated Sepsis: Current Estimates and Limitations Carolin Fleischmann-Struzek, André Scherag, Neill K. J. Adhikari et al. · American Journal of Respiratory and Critical Care Medicine | 28 Sep 2015 | 3,667 |
| 40 | International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics* Brahm Goldstein, Brett P. Giroir, Adrienne G. Randolph · Pediatric Critical Care Medicine | 2005 | 3,655 |
| 41 | Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units Jean‐Louis Vincent, Arnaldo de Mendonça, Francis R. L. Cantraine et al. · Critical Care Medicine | Nov 1998 | 3,555 |
| 42 | The APACHE III Prognostic System William A. Knaus, Douglas P. Wagner, Elizabeth A. Draper et al. · CHEST Journal | Dec 1991 | 3,502 |
| 43 | Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial William D. Schweickert, Mark C. Pohlman, Anne S. Pohlman et al. · The Lancet | May 2009 | 3,358 |
| 44 | Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock R. Phillip Dellinger, Jean M. Carlet, Henry Masur et al. · Intensive Care Medicine | 3 Mar 2004 | 3,339 |
| 45 | Delirium in Mechanically Ventilated Patients Eugene Wesley Ely, Sharon K. Inouye, Gordon R. Bernard et al. · JAMA | 5 Dec 2001 | 3,249 |
| 46 | Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock Djillali Annane · JAMA | 21 Aug 2002 | 3,104 |
| 47 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis Richard Moreau, Rajiv Jalan, Pere Ginès et al. · Gastroenterology | 6 Mar 2013 | 3,048 |
| 48 | Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients Flávio Lopes Ferreira · JAMA | 10 Oct 2001 | 2,958 |
| 49 | Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis Frank Martin Brunkhorst et al. · New England Journal of Medicine | 9 Jan 2008 | 2,942 |
| 50 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference for the International Sepsis Definitions Conference, Mitchell M. Levy, Mitchell P. Fink et al. · Intensive Care Medicine | 28 Mar 2003 | 2,908 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.