Most cited papers in Barrier Structure and Function Studies
What are the most cited papers in Barrier Structure and Function Studies?
The most cited paper in Barrier Structure and Function Studies is "Changes of Intestinal Functions in Liver Cirrhosis" (Hiroshi Fukui, Reiner Wiest, 2016), with 6,814 citations. Next come "THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE" (6,512) and "Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo" (5,970).
Showing 50 of 99 papers. Every paper with more than 1,060 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Changes of Intestinal Functions in Liver Cirrhosis Hiroshi Fukui, Reiner Wiest · Inflammatory Intestinal Diseases | 2016 | 6,814 |
| 2 | THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE Richard C. Graham, Morris J. Karnovsky · Journal of Histochemistry & Cytochemistry | Apr 1966 | 6,512 |
| 3 | Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen · Science | 14 Apr 2005 | 5,970 |
| 4 | Astrocyte–endothelial interactions at the blood–brain barrier N. Joan Abbott, Lars Rönnbäck, Elisabeth Hansson · Nature reviews. Neuroscience | 21 Dec 2005 | 5,649 |
| 5 | Structure and function of the blood–brain barrier N. Joan Abbott, Adjanie Patabendige, Diana E. M. Dolman et al. · Neurobiology of Disease | 6 Aug 2009 | 5,185 |
| 6 | Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice Patrice D. Cani, Rodrigo Bibiloni, Claude Knauf et al. · Diabetes | 27 Feb 2008 | 4,821 |
| 7 | Intestinal mucosal barrier function in health and disease Jerrold R. Turner · Nature reviews. Immunology | 26 Oct 2009 | 3,971 |
| 8 | Physiology of Microglia Helmut Kettenmann, Uwe‐Karsten Hanisch, Mami Noda et al. · Physiological Reviews | Apr 2011 | 3,572 |
| 9 | The Blood–Brain Barrier Richard Daneman, Alexandre Prat · Cold Spring Harbor Perspectives in Biology | 2015 | 3,413 |
| 10 | The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders Berislav V. Zloković · Neuron | 2008 | 3,300 |
| 11 | Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders Melanie D. Sweeney, Abhay P. Sagare, Berislav V. Zloković · Nature Reviews Neurology | 29 Jan 2018 | 3,128 |
| 12 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Berislav V. Zloković · Nature reviews. Neuroscience | 3 Nov 2011 | 3,016 |
| 13 | Pericytes regulate the blood–brain barrier Annika Armulik, Guillem Genové, Maarja Andaloussi Mäe et al. · Nature | 13 Oct 2010 | 2,915 |
| 14 | Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment Aleksandar David Kostic, Eunyoung Chun, Lauren T. Robertson et al. · Cell Host & Microbe | Aug 2013 | 2,810 |
| 15 | The blood-brain barrier: Bottleneck in brain drug development William M. Pardridge · NeuroRx | 14 Dec 2004 | 2,809 |
| 16 | The Blood-Brain Barrier/Neurovascular Unit in Health and Disease Brian T. Hawkins, Thomas P. Davis · Pharmacological Reviews | 23 May 2005 | 2,668 |
| 17 | FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE Thomas S. Reese, Morris J. Karnovsky · The Journal of Cell Biology | Jul 1967 | 2,647 |
| 18 | Occludin: a novel integral membrane protein localizing at tight junctions. Mikio Furuse, Tetsuaki Hirase, Masahiko Itoh et al. · The Journal of Cell Biology | 15 Dec 1993 | 2,574 |
| 19 | Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria María Rescigno, Matteo Urbano, Barbara Valzasina et al. · Nature Immunology | Apr 2001 | 2,556 |
| 20 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease Costantino Iadecola · Neuron | Sep 2017 | 2,537 |
| 21 | Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability Patrice D. Cani, Sam Possemiers, Tom Van de Wiele et al. · Gut | 24 Feb 2009 | 2,525 |
| 22 | The gut microbiota influences blood-brain barrier permeability in mice Viorica Braniste, Maha Al‐Asmakh, Czeslawa Kowal et al. · Science Translational Medicine | 19 Nov 2014 | 2,520 |
| 23 | Multifunctional strands in tight junctions Shöichiro Tsukita, Mikio Furuse, Masahiko Itoh · Nature Reviews Molecular Cell Biology | Apr 2001 | 2,511 |
| 24 | JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN Milton Brightman, Thomas S. Reese · The Journal of Cell Biology | Mar 1969 | 2,492 |
| 25 | Development, maintenance and disruption of the blood-brain barrier Birgit Obermeier, Richard Daneman, Richard M. Ransohoff · Nature Medicine | Dec 2013 | 2,492 |
| 26 | Blood-Brain Barrier: From Physiology to Disease and Back Melanie D. Sweeney, Zhen Zhao, Axel Montagne et al. · Physiological Reviews | 3 Oct 2018 | 2,268 |
| 27 | The blood–brain barrier: an overview Praveen Ballabh, Alex Braun, Maiken Nedergaard · Neurobiology of Disease | 10 Apr 2004 | 2,260 |
| 28 | Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer Aleix Prat, Joel S. Parker, Olga A. Karginova et al. · Breast Cancer Research | 2 Sep 2010 | 2,184 |
| 29 | Pericytes are required for blood–brain barrier integrity during embryogenesis Richard Daneman, Lu Zhou, Amanuel A. Kebede et al. · Nature | 13 Oct 2010 | 2,183 |
| 30 | Blood-Brain Barrier Breakdown in the Aging Human Hippocampus Axel Montagne, Samuel R. Barnes, Melanie D. Sweeney et al. · Neuron | 2015 | 2,164 |
| 31 | Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers Luying Peng, Zhongrong Li, Robert S. Green et al. · Journal of Nutrition | 22 Jul 2009 | 2,133 |
| 32 | Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin Mikio Furuse, Kohji Fujita, Takashi Hiiragi et al. · The Journal of Cell Biology | 29 Jun 1998 | 2,097 |
| 33 | Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain Linda J. Lawson, Victor Hugh Perry, Pietro Dri et al. · Neuroscience | 1990 | 2,077 |
| 34 | A molecular atlas of cell types and zonation in the brain vasculature Michael Vanlandewijck, Liqun He, Maarja Andaloussi Mäe et al. · Nature | 13 Feb 2018 | 2,056 |
| 35 | Mechanisms regulating intestinal barrier integrity and its pathological implications Chaithanya Chelakkot, Jaewang Ghim, Sung Ho Ryu · Experimental & Molecular Medicine | Aug 2018 | 2,021 |
| 36 | Stereological Principles for Morphometry in Electron Microscopic Cytology Ewald R. Weibel · International review of cytology | 1969 | 1,957 |
| 37 | Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice Takehiro Nitta, Masaki Hata, Shimpei Gotoh et al. · The Journal of Cell Biology | 12 May 2003 | 1,942 |
| 38 | Capillary pericytes regulate cerebral blood flow in health and disease Catherine N. Hall, Clare Reynell, Bodil Gesslein et al. · Nature | 26 Mar 2014 | 1,922 |
| 39 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target Laurent Peyrin‐Biroulet et al. · The American Journal of Gastroenterology | 25 Aug 2015 | 1,861 |
| 40 | A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity Hossam Kadry, Behnam Noorani, Luca Cucullo · Fluids and Barriers of the CNS | 18 Nov 2020 | 1,858 |
| 41 | The blood–brain barrier: Structure, regulation and drug delivery Di Wu, Qi Chen, Xiaojie Chen et al. · Signal Transduction and Targeted Therapy | 25 May 2023 | 1,832 |
| 42 | The blood–brain barrier and blood–tumour barrier in brain tumours and metastases Costas Arvanitis, Gino B. Ferraro, Rakesh K. Jain · Nature reviews. Cancer | 10 Oct 2019 | 1,819 |
| 43 | Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction Daniel A. Nation, Melanie D. Sweeney, Axel Montagne et al. · Nature Medicine | 8 Jan 2019 | 1,796 |
| 44 | Mechanisms, challenges and opportunities in stroke Eng H. Lo, Turgay Dalkara, Michael A. Moskowitz · Nature reviews. Neuroscience | May 2003 | 1,784 |
| 45 | Intestinal barrier function: Molecular regulation and disease pathogenesis Katherine R. Groschwitz, Simon Patrick Hogan · Journal of Allergy and Clinical Immunology | 27 Jun 2009 | 1,778 |
| 46 | Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Hania Kébir, Katharina Kreymborg, Igal Ifergan et al. · Nature Medicine | 9 Sep 2007 | 1,766 |
| 47 | Phenotypic Heterogeneity of the Endothelium William C. Aird · Circulation Research | 2 Feb 2007 | 1,753 |
| 48 | Establishment and Dysfunction of the Blood-Brain Barrier Zhen Zhao, Amy R. Nelson, Christer Betsholtz et al. · Cell | Nov 2015 | 1,719 |
| 49 | Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon Gerald P. Morris, Paul L. Beck, Margaret S. Herridge et al. · Gastroenterology | Feb 1989 | 1,718 |
| 50 | Astrocytes induce blood–brain barrier properties in endothelial cells Robert Charles Janzer, MARTIN C. RAFF · Nature | 1987 | 1,637 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.