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Topic · Neurology

Barrier Structure and Function Studies

Barrier Structure and Function Studies is a research topic within Neurology. Science Explorer counts 16k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the structure, function, and dysfunction of the blood-brain barrier, as well as the interactions between astrocytes, endothelial cells, and pericytes in the neurovascular unit. It covers topics such as tight junctions, CNS drug delivery, neurological diseases, and the role of various cell types in maintaining vascular homeostasis.

  • Blood-Brain Barrier
  • Neurovascular Unit
  • Tight Junctions
  • Pericytes
  • Endothelial Cells
  • Astrocyte Interactions
  • Barrier Dysfunction
  • CNS Drug Delivery
  • Neurological Diseases
  • Vascular Homeostasis
Research works
16k
fractional, since 1950
In the world top 10%
1.5k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+29%
the tick is no change
Largest producer
China
45% of the 10 largest, 2022-now
Barrier Structure and Function Studies

Which countries lead Barrier Structure and Function Studies research?

By volume, China and the United States publish the most (1.3k and 781 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.3k works
  2. 2 United States 781 works
  3. 3 Japan 175 works
  4. 4 Germany 151 works
  5. 5 United Kingdom 104 works
  6. 6 South Korea 102 works
  7. 7 India 101 works
  8. 8 France 88 works
  9. 9 Italy 82 works
  10. 10 Canada 63 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 44.7%United States: 26.2%Japan: 5.9%Germany: 5.1%6 others listed: 18.1%45%largest
China1,331 · 44.7%United States781 · 26.2%Japan175 · 5.9%Germany151 · 5.1%6 others listed540 · 18.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Barrier Structure and Function Studies research?

By volume in 2022-now, Harvard University publishes the most Barrier Structure and Function Studies research, followed by Sun Yat-sen University and Zhejiang University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 32 works
  2. 2 Sun Yat-sen UniversityChina 29 works
  3. 3 Zhejiang UniversityChina 27 works
  4. 4 Shanghai Jiao Tong UniversityChina 26 works
  5. 5 Capital Medical UniversityChina 25 works
  6. 6 Fudan UniversityChina 22 works
  7. 7 Peking UniversityChina 22 works
  8. 8 InsermFrance 21 works
  9. 9 Nanjing Medical UniversityChina 20 works
  10. 10 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 17 works

Who are the leading researchers in Barrier Structure and Function Studies?

The most-cited researchers publishing on Barrier Structure and Function Studies include Mark J. Daly, Giuseppe Remuzzi and Róbert Langer.

  1. 1 Mark J. Daly United States 403k citations
  2. 2 Giuseppe Remuzzi Italy 328k citations
  3. 3 Róbert Langer United States 303k citations
  4. 4 John Q. Trojanowski United States 286k citations
  5. 5 Charles M. Perou United States 263k citations
  6. 6 Kaj Blennow Sweden 247k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Barrier Structure and Function Studies?

The most cited paper in Barrier Structure and Function Studies is "Changes of Intestinal Functions in Liver Cirrhosis" (Hiroshi Fukui, Reiner Wiest, 2016), with 6,814 citations. Next come "THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE" (6,512) and "Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo" (5,970).

Most cited papers
#PaperReleasedCitations
1 Changes of Intestinal Functions in Liver Cirrhosis Hiroshi Fukui, Reiner Wiest · Inflammatory Intestinal Diseases Open access 2016 6,814
2 THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE Richard C. Graham, Morris J. Karnovsky · Journal of Histochemistry & Cytochemistry Open access Apr 1966 6,512
3 Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen · Science 14 Apr 2005 5,970
4 Astrocyte–endothelial interactions at the blood–brain barrier N. Joan Abbott, Lars Rönnbäck, Elisabeth Hansson · Nature reviews. Neuroscience Review 21 Dec 2005 5,649
5 Structure and function of the blood–brain barrier N. Joan Abbott, Adjanie Patabendige, Diana E. M. Dolman et al. · Neurobiology of Disease Open access 6 Aug 2009 5,185
All 99 most cited papers, with filters and sorting

Where is Barrier Structure and Function Studies research done?

The largest centres of Barrier Structure and Function Studies research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Hangzhou (China).

Largest cities, 2022-now

  1. 1 BeijingChina 154 works
  2. 2 ShanghaiChina 97 works
  3. 3 GuangzhouChina 94 works
  4. 4 HangzhouChina 60 works
  5. 5 NanjingChina 59 works
  6. 6 WuhanChina 51 works
  7. 7 ParisFrance 44 works
  8. 8 ChengduChina 43 works
  9. 9 TokyoJapan 42 works
  10. 10 SeoulSouth Korea 42 works
See Barrier Structure and Function Studies on the map

Where is the best place to study Barrier Structure and Function Studies?

Among universities, judged by research, Harvard University, Capital Medical University and Fudan University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 13.97%fractional works in this field (log) →share of work in the world top 10% →Fudan UniversityHarvard UniversityCapital Medical Univ…Shanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 85.315.4%3.2×32 -2.0%
2Capital Medical UniversityChina 64.713.3%7.5×25 +70.3%
3Fudan UniversityChina 64.416.1%4.5×22 +88.9%
4Shanghai Jiao Tong UniversityChina 62.012.8%2.9×26 +22.6%
5Zhejiang UniversityChina 58.910.2%3.2×27 +70.9%
6University College LondonUnited Kingdom 58.820.7%1.8×9 +23.7%
7Sun Yat-sen UniversityChina 58.17.9%4.5×29 +43.7%
8Zhejiang Chinese Medical UniversityChina 57.116.1%17.7×14 +200.5%
9Southern Medical UniversityChina 56.815.2%8.1×16 +32.5%
10Peking UniversityChina 56.512.0%3.5×22 +32.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Barrier Structure and Function Studies, country by country

Is Barrier Structure and Function Studies research growing?

Output in 2022-2025 was 29% higher than in 2018-2021, peaking in 2026. The fastest-growing topics are Barrier Structure and Function Studies.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Barrier Structure and Function Studies as a percentage of every work published that year, 0.011% in 2024.

still counting0.020%0.040%0.060%Barrier Structure and Function Studies0.015% in 202519801990200020102020

Fractional works of Barrier Structure and Function Studies over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Barrier Structure and Function Studies10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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