Most cited papers in Bioactive Compounds and Antitumor Agents
What are the most cited papers in Bioactive Compounds and Antitumor Agents?
The most cited paper in Bioactive Compounds and Antitumor Agents is "Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes" (Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner, 1991), with 6,700 citations. Next come "NITRIC OXIDE AND MACROPHAGE FUNCTION" (4,227) and "Crosstalk of reactive oxygen species and NF-κB signaling" (3,489).
Showing 50 of 100 papers. Every paper with more than 601 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner · Free Radical Biology and Medicine | 1991 | 6,700 |
| 2 | NITRIC OXIDE AND MACROPHAGE FUNCTION John D. MacMicking, Q W Xie, Carl Nathan · Annual Review of Immunology | Apr 1997 | 4,227 |
| 3 | Crosstalk of reactive oxygen species and NF-κB signaling Michael J Morgan, Zheng-gang Liu · Cell Research | 28 Dec 2010 | 3,489 |
| 4 | Molecular basis of agonism and antagonism in the oestrogen receptor Andrzej Marek Brzozowski, Ashley C. W. Pike, Zbigniew Dauter et al. · Nature | Oct 1997 | 3,370 |
| 5 | DNA Topoisomerases: Structure, Function, and Mechanism James J. Champoux · Annual Review of Biochemistry | Jun 2001 | 2,754 |
| 6 | Anticancer potential of curcumin: preclinical and clinical studies. Bharat Bhushan Aggarwal, Anushree Jai Kumar, Alok Chandra Bharti · PubMed | May 2003 | 2,576 |
| 7 | Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry | Nov 1985 | 2,367 |
| 8 | Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan, Aequorea Osamu Shimomura, Frank H. Johnson, Yo Saiga · Journal of Cellular and Comparative Physiology | Jun 1962 | 2,360 |
| 9 | T Cell Activation Jennifer E. Smith‐Garvin, Gary A. Koretzky, Martha S. Jordan · Annual Review of Immunology | 8 Jan 2009 | 2,151 |
| 10 | Estrogen Receptors: How Do They Signal and What Are Their Targets Nina Heldring, Ashley C. W. Pike, Sandra Andersson et al. · Physiological Reviews | Jul 2007 | 1,887 |
| 11 | Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action Kenta Hara, Yoshiko Maruki, Samuel Long et al. · Cell | Jul 2002 | 1,814 |
| 12 | Role of Quinones in Toxicology Judy L. Bolton, Michael A. Trush, T.M. Penning et al. · Chemical Research in Toxicology | 23 Feb 2000 | 1,707 |
| 13 | Natural Products in Drug Discovery and Development Gordon M. L. Cragg, David J. Newman, Kenneth M. Snader · Journal of Natural Products | 1997 | 1,592 |
| 14 | Apoptosis: A Target for Anticancer Therapy Claire M. Pfeffer, Amareshwar T.K. Singh · International Journal of Molecular Sciences | 2 Feb 2018 | 1,570 |
| 15 | Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science | 26 Oct 1984 | 1,551 |
| 16 | Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA Ben F. Luisi, Wei Xu, Zbyszek Otwinowski et al. · Nature | Aug 1991 | 1,519 |
| 17 | Free Radicals as Mediators of Tissue Injury and Disease James P. Kehrer · Critical Reviews in Toxicology | 1993 | 1,462 |
| 18 | A review on therapeutic potential of Nigella sativa: A miracle herb Aftab Ahmad, Asif Husain, Mohd Abdul Mujeeb et al. · Asian Pacific Journal of Tropical Biomedicine | 28 Feb 2013 | 1,437 |
| 19 | Pharmacology of oleanolic acid and ursolic acid Jie Liu · Journal of Ethnopharmacology | Dec 1995 | 1,432 |
| 20 | Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Medicinal Chemistry | 12 Nov 2012 | 1,355 |
| 21 | Impact of Natural Products on Developing New Anti-Cancer Agents Gordon M. L. Cragg, Paul G. Grothaus, David J. Newman · Chemical Reviews | 7 May 2009 | 1,306 |
| 22 | Mechanism of Quinolone Action and Resistance Katie J. Aldred, Robert J. Kerns, Neil Osheroff · Biochemistry | 27 Feb 2014 | 1,283 |
| 23 | Base-excision repair of oxidative DNA damage Sheila S. David, Valerie L. O’Shea, Sucharita Kundu · Nature | Jun 2007 | 1,266 |
| 24 | Biomedical Importance of Indoles Nagendra Kumar Kaushik, Neha Kaushik, Pankaj Attri et al. · Molecules | 6 Jun 2013 | 1,245 |
| 25 | The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer Vijay Kumar, Pierre Chambon · Cell | Oct 1988 | 1,238 |
| 26 | Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide Yun Soo Bae, Sang Won Kang, Min Seok Seo et al. · Journal of Biological Chemistry | 1997 | 1,218 |
| 27 | Mechanisms and functions of eph and ephrin signalling Klas Kullander, Rüdiger Klein · Nature Reviews Molecular Cell Biology | Jul 2002 | 1,162 |
| 28 | Pharmacological and toxicological properties of Nigella sativa Badreldin H. Ali, Gerald Blunden · Phytotherapy Research | Apr 2003 | 1,126 |
| 29 | Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. Q W Xie, R Whisnant, C F Nathan · The Journal of Experimental Medicine | Jun 1993 | 1,124 |
| 30 | Natural products to drugs: natural product-derived compounds in clinical trials Mark S. Butler · Natural Product Reports | 2008 | 1,080 |
| 31 | Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. John Chan, Xing Yi, Richard S. Magliozzo et al. · The Journal of Experimental Medicine | Apr 1992 | 1,072 |
| 32 | Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences | 10 Dec 1996 | 1,040 |
| 33 | Molecular mechanisms of quinone cytotoxicity Peter James O'Brien · Chemico-Biological Interactions | 1991 | 1,037 |
| 34 | Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed | 15 Sep 1989 | 1,034 |
| 35 | Structure of calmodulin refined at 2.2 Å resolution Yarlagadda S. Babu, Charles E. Bugg, William J. Cook · Journal of Molecular Biology | Nov 1988 | 1,030 |
| 36 | A Critical Review on Chagas Disease Chemotherapy José Rodrigues Coura, Solange Lisboa de Castro · Memórias do Instituto Oswaldo Cruz | 2002 | 1,013 |
| 37 | Pharmacology of drugs that alter multidrug resistance in cancer. James M. Ford, William N. Hait · Pharmacological Reviews | Sep 1990 | 983 |
| 38 | Autoxidation versus Covalent Binding of Quinones as the Mechanism of Toxicity of Dopamine, 6-Hydroxydopamine, and Related Compounds toward C1300 Neuroblastoma Cells in Vitro Doyle G. Graham, S M Tiffany, William Robert Bell et al. · Molecular Pharmacology | Jul 1978 | 962 |
| 39 | Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein Chao‐Lan Yu, Debra J. Meyer, George S. Campbell et al. · Science | 7 Jul 1995 | 947 |
| 40 | Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Adriana Haimovitz‐Friedman, C. Kan, Desiree Ehleiter et al. · The Journal of Experimental Medicine | Aug 1994 | 910 |
| 41 | Use of plant extracts in fish aquaculture as an alternative to chemotherapy: Current status and future perspectives Miriam Reverter, Nataly Bontemps, David Lecchini et al. · Aquaculture | 7 Jun 2014 | 901 |
| 42 | Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review Weiling Xue, David Warshawsky · Toxicology and Applied Pharmacology | 11 Jan 2005 | 894 |
| 43 | Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance Miguel Angel Fuertes, Carlos Alonso‐Moreno, Jose Manuel Trigo Perez · Chemical Reviews | 22 Feb 2003 | 890 |
| 44 | Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. K M Tewey, G L Chen, Eric M. Nelson et al. · Journal of Biological Chemistry | Jul 1984 | 888 |
| 45 | The chemistry of isatins: a review from 1975 to 1999 Joaquim F. M. da Silva, Simon J. Garden, Angelo Cunha Pinto · Journal of the Brazilian Chemical Society | Jun 2001 | 886 |
| 46 | Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2 Lindsay K. Caesar, Nadja B. Cech · Natural Product Reports | 2019 | 877 |
| 47 | Natural products: An evolving role in future drug discovery Bhuwan B. Mishra, Vinod K. Tiwari · European Journal of Medicinal Chemistry | 2 Sep 2011 | 868 |
| 48 | A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery Uttpal Anand, Nadia Judith Jacobo-Herrera, Ammar B. Altemimi et al. · Metabolites | Nov 2019 | 867 |
| 49 | Immunomodulatory and therapeutic properties of the Nigella sativa L. seed Mohamed Labib Salem · International Immunopharmacology | 2 Jul 2005 | 857 |
| 50 | Drugging Topoisomerases: Lessons and Challenges Yves G. Pommier · ACS Chemical Biology | 21 Dec 2012 | 847 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.