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Topic · Toxicology

Bioactive Compounds and Antitumor Agents

Bioactive Compounds and Antitumor Agents is a research topic within Toxicology. Science Explorer counts 25k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of quinones in toxicology and pharmacology, focusing on their cytotoxic effects, NAD(P)H:Quinone Oxidoreductase activity, apoptosis induction, and potential as anticancer and antimicrobial agents. The papers cover a wide range of topics including cellular pharmacology studies, mechanisms of cytotoxic action, pharmacological properties, and the synthesis and evaluation of quinone derivatives.

  • Quinones
  • Toxicology
  • Pharmacology
  • Cytotoxicity
  • NAD(P)H:Quinone Oxidoreductase
  • Apoptosis
  • Anticancer Agents
  • Reactive Oxygen Species
  • Antimicrobial Activity
  • Cell Signaling
Research works
25k
fractional, since 1950
In the world top 10%
2.4k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+3%
the tick is no change
Largest producer
China
34% of the 10 largest, 2022-now
Bioactive Compounds and Antitumor Agents

Which countries lead Bioactive Compounds and Antitumor Agents research?

By volume, China and India publish the most (741 and 536 works in 2022-now).

By volume, 2022-now

  1. 1 China 741 works
  2. 2 India 536 works
  3. 3 United States 202 works
  4. 4 Türkiye 121 works
  5. 5 Brazil 118 works
  6. 6 Egypt 114 works
  7. 7 Saudi Arabia 100 works
  8. 8 South Korea 91 works
  9. 9 Iran 89 works
  10. 10 Russia 86 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 33.7%India: 24.4%United States: 9.2%Türkiye: 5.5%6 others listed: 27.2%34%largest
China741 · 33.7%India536 · 24.4%United States202 · 9.2%Türkiye121 · 5.5%6 others listed598 · 27.2%

Shares of the rows listed above, not of the whole node.

Which institutions lead Bioactive Compounds and Antitumor Agents research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Bioactive Compounds and Antitumor Agents research, followed by Chinese Academy of Sciences and Council of Scientific and Industrial Research.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 45 works
  2. 2 Chinese Academy of SciencesChina 30 works
  3. 3 Council of Scientific and Industrial ResearchIndia 22 works
  4. 4 King Saud UniversitySaudi Arabia 21 works
  5. 5 Cairo UniversityEgypt 16 works
  6. 6 Centre National de la Recherche ScientifiqueFrance 15 works
  7. 7 Sichuan UniversityChina 14 works
  8. 8 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 13 works
  9. 9 Academy of Scientific and Innovative ResearchIndia 13 works
  10. 10 Islamic Azad University, TehranIran 12 works

Who are the leading researchers in Bioactive Compounds and Antitumor Agents?

The most-cited researchers publishing on Bioactive Compounds and Antitumor Agents include Guido Kroemer, Jun Wang and Gordon Brent Mills.

  1. 1 Guido Kroemer France 386k citations
  2. 2 Jun Wang China 340k citations
  3. 3 Gordon Brent Mills United States 265k citations
  4. 4 Amirhossein Sahebkar Iran 258k citations
  5. 5 Richard Anthony Flavell United States 237k citations
  6. 6 Alberto Mantovani Italy 224k citations
  7. 7 Kai You Wang China 224k citations
  8. 8 George M. Sheldrick Germany 220k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Bioactive Compounds and Antitumor Agents?

The most cited paper in Bioactive Compounds and Antitumor Agents is "Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes" (Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner, 1991), with 6,700 citations. Next come "NITRIC OXIDE AND MACROPHAGE FUNCTION" (4,227) and "Crosstalk of reactive oxygen species and NF-κB signaling" (3,489).

Most cited papers
#PaperReleasedCitations
1 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner · Free Radical Biology and Medicine 1991 6,700
2 NITRIC OXIDE AND MACROPHAGE FUNCTION John D. MacMicking, Q W Xie, Carl Nathan · Annual Review of Immunology Review Apr 1997 4,227
3 Crosstalk of reactive oxygen species and NF-κB signaling Michael J Morgan, Zheng-gang Liu · Cell Research Open access 28 Dec 2010 3,489
4 Molecular basis of agonism and antagonism in the oestrogen receptor Andrzej Marek Brzozowski, Ashley C. W. Pike, Zbigniew Dauter et al. · Nature Oct 1997 3,370
5 DNA Topoisomerases: Structure, Function, and Mechanism James J. Champoux · Annual Review of Biochemistry Review Jun 2001 2,754
All 100 most cited papers, with filters and sorting

Where is Bioactive Compounds and Antitumor Agents research done?

The largest centres of Bioactive Compounds and Antitumor Agents research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Riyadh (Saudi Arabia). Among places with at least 20 works in it, it is an unusually large share of all research in Giza.

Largest cities, 2022-now

  1. 1 BeijingChina 77 works
  2. 2 ShanghaiChina 47 works
  3. 3 GuangzhouChina 38 works
  4. 4 RiyadhSaudi Arabia 37 works
  5. 5 ChennaiIndia 36 works
  6. 6 CairoEgypt 34 works
  7. 7 NanjingChina 34 works
  8. 8 SeoulSouth Korea 32 works
  9. 9 ChengduChina 32 works
  10. 10 MoscowRussia 30 works

Where it is the local speciality

  1. GizaEG · 27.5 works6.0×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Bioactive Compounds and Antitumor Agents than the world average.

See Bioactive Compounds and Antitumor Agents on the map

Where is the best place to study Bioactive Compounds and Antitumor Agents?

Among universities, judged by research, King Saud University, Al-Azhar University and Cairo University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 16.38%fractional works in this field (log) →share of work in the world top 10% →Al-Azhar UniversityCairo UniversityKing Saud UniversityAcademy of Scientifi…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1King Saud UniversitySaudi Arabia 72.814.9%7.5×21 +28.5%
2Al-Azhar UniversityEgypt 62.439.6%8.2×9 -0.3%
3Cairo UniversityEgypt 58.721.4%7.3×16 +27.5%
4Academy of Scientific and Innovative ResearchIndia 39.48.4%14.5×13 +117.2%
5Sichuan UniversityChina 37.215.4%2.1×14 +26.9%
6Saveetha UniversityIndia 35.511.5%4.3×12 +524.5%
7King Abdulaziz UniversitySaudi Arabia 32.920.0%5.4×8 -9.9%
8Wenzhou Medical UniversityChina 30.28.7%6.6×9 +22.2%
9Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 26.312.7%4.3×13 -31.1%
10China Pharmaceutical UniversityChina 24.011.2%17.2×11 -27.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Bioactive Compounds and Antitumor Agents, country by country

Is Bioactive Compounds and Antitumor Agents research growing?

Output in 2022-2025 was 3% higher than in 2018-2021, peaking in 2024. The fastest-growing topics are Bioactive Compounds and Antitumor Agents.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Bioactive Compounds and Antitumor Agents as a percentage of every work published that year, 0.015% in 2024.

still counting0.020%0.040%0.060%Bioactive Compounds and Antitumor Agents0.013% in 202519801990200020102020

Fractional works of Bioactive Compounds and Antitumor Agents over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Bioactive Compounds and Antitumor Agents10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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