Most cited papers in Biochemical and Structural Characterization
What are the most cited papers in Biochemical and Structural Characterization?
The most cited paper in Biochemical and Structural Characterization is "Integrins: Versatility, modulation, and signaling in cell adhesion" (Richard O. Hynes, 1992), with 9,972 citations. Next come "Principles that Govern the Folding of Protein Chains" (7,215) and "Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd" (5,661).
Showing 50 of 99 papers. Every paper with more than 985 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Integrins: Versatility, modulation, and signaling in cell adhesion Richard O. Hynes · Cell | Apr 1992 | 9,972 |
| 2 | Principles that Govern the Folding of Protein Chains Christian B. Anfinsen · Science | 20 Jul 1973 | 7,215 |
| 3 | Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd Robert D Fleischmann et al. · Science | 28 Jul 1995 | 5,661 |
| 4 | Fingerprinting genomes using PCR with arbitrary primers John B. Welsh, Michael McClelland · Nucleic Acids Research | 1990 | 5,224 |
| 5 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Robert E. W. Hancock, Hans‐Georg Sahl · Nature Biotechnology | Dec 2006 | 4,225 |
| 6 | Intracellular Aspects of the Process of Protein Synthesis George E. Palade · Science | Aug 1975 | 3,595 |
| 7 | The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins William H. Landschulz, Peter F. Johnson, Steven Lanier McKnight · Science | 24 Jun 1988 | 3,521 |
| 8 | Defensins: antimicrobial peptides of innate immunity Tomas Ganz · Nature reviews. Immunology | Sep 2003 | 3,100 |
| 9 | Natural products: A continuing source of novel drug leads Gordon M. L. Cragg, David J. Newman · Biochimica et Biophysica Acta (BBA) - General Subjects | 18 Feb 2013 | 2,925 |
| 10 | A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins Cornelis Murre, Patrick Page-McCaw, David Baltimore · Cell | Mar 1989 | 2,742 |
| 11 | Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis George A. O’Toole, Roberto Kolter · Molecular Microbiology | Apr 1998 | 2,555 |
| 12 | Peptide Antimicrobial Agents Håvard Jenssen, Pamela Hamill, Robert E. W. Hancock · Clinical Microbiology Reviews | Jul 2006 | 2,519 |
| 13 | APD3: the antimicrobial peptide database as a tool for research and education Guangshun Wang, Xia Li, Zhe Wang · Nucleic Acids Research | 23 Nov 2015 | 2,445 |
| 14 | Peptidoglycan structure and architecture Waldemar Vollmer, Didier Blanot, Miguel Angel de Pedro · FEMS Microbiology Reviews | 16 Feb 2008 | 2,424 |
| 15 | Molecular mechanism and physiological functions of clathrin-mediated endocytosis Harvey T. McMahon, Emmanuel Boucrot · Nature Reviews Molecular Cell Biology | 22 Jul 2011 | 2,336 |
| 16 | Analysis of membrane and surface protein sequences with the hydrophobic moment plot David S Eisenberg, Erich M. Schwarz, Michael C. Komaromy et al. · Journal of Molecular Biology | Oct 1984 | 2,335 |
| 17 | Fusion protein linkers: Property, design and functionality Xiaoying Chen, Jennica L. Zaro, Wei‐Chiang Shen · Advanced Drug Delivery Reviews | 29 Sep 2012 | 2,167 |
| 18 | Rethinking amide bond synthesis Vijaya Raghavan Pattabiraman, Jeffrey W. Bode · Nature | Dec 2011 | 2,162 |
| 19 | Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature Paul G. Arnison et al. · Natural Product Reports | 20 Nov 2012 | 2,136 |
| 20 | Therapeutic peptides: current applications and future directions Lei Wang, Nanxi Wang, Wenping Zhang et al. · Signal Transduction and Targeted Therapy | 14 Feb 2022 | 2,120 |
| 21 | Designing antimicrobial peptides: form follows function Christopher D. Fjell, Jan A. Hiss, Robert E. W. Hancock et al. · Nature Reviews Drug Discovery | 16 Dec 2011 | 2,061 |
| 22 | The Future of Peptide‐based Drugs David J. Craik, David P. Fairlie, Spiros Liras et al. · Chemical Biology & Drug Design | 17 Dec 2012 | 2,015 |
| 23 | Reaching for high-hanging fruit in drug discovery at protein–protein interfaces James A. Wells, Christopher L. McClendon · Nature | Dec 2007 | 1,989 |
| 24 | Antimicrobial Peptides: An Emerging Category of Therapeutic Agents Margit Mahlapuu, Joakim Håkansson, Lovisa Ringstad et al. · Frontiers in Cellular and Infection Microbiology | 26 Dec 2016 | 1,971 |
| 25 | Tumor Necrosis Factor (TNF) Lloyd J. Old · Science | 8 Nov 1985 | 1,916 |
| 26 | β-Peptides: From Structure to Function Richard Ping Cheng, Samuel H. Gellman, William F. DeGrado · Chemical Reviews | Oct 2001 | 1,860 |
| 27 | Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin Giampietro Schiavo, Fabio Benfenati, Bernard Poulain et al. · Nature | Oct 1992 | 1,856 |
| 28 | Staphylococcus epidermidis — the 'accidental' pathogen Michael J. Otto · Nature Reviews Microbiology | 16 Jul 2009 | 1,846 |
| 29 | A new type of synthetic peptide library for identifying ligand-binding activity Kit Sang Lam, Sydney E. Salmon, Evan M. Hersh et al. · Nature | 7 Nov 1991 | 1,816 |
| 30 | Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin Bijan Zakeri, Jacob O. Fierer, Emrah Çelik et al. · Proceedings of the National Academy of Sciences | 24 Feb 2012 | 1,776 |
| 31 | Integrin ligands at a glance Jonathan D. Humphries, Adam Byron, Martin James Humphries · Journal of Cell Science | 20 Sep 2006 | 1,727 |
| 32 | “Green” Nanotechnologies: Synthesis of Metal Nanoparticles Using Plants Valentin V. Makarov, Andrew J. Love, Olga V. Sinitsyna et al. · Acta Naturae | 15 Mar 2014 | 1,699 |
| 33 | Turns in Peptides and Proteins George D. Rose, Lila M. Glerasch, John A. Smith · Advances in protein chemistry | 1985 | 1,672 |
| 34 | Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields Yuchen Huan, Qing Kong, Haijin Mou et al. · Frontiers in Microbiology | 16 Oct 2020 | 1,633 |
| 35 | Liquid crystalline spinning of spider silk Fritz W. Vollrath, David P. Knight · Nature | Mar 2001 | 1,632 |
| 36 | Peptide Antibiotics and Their Role in Innate Immunity Hans G. Boman · Annual Review of Immunology | Apr 1995 | 1,626 |
| 37 | Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand Jian-Ping Xiong, Thilo Stehle, Rongguang Zhang et al. · Science | 5 Apr 2002 | 1,616 |
| 38 | Molecular biomimetics: nanotechnology through biology Mehmet Sarıkaya, Candan Tamerler, Alex K.‐Y. Jen et al. · Nature Materials | Sep 2003 | 1,602 |
| 39 | Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus Timothy J. Foster, Joan A. Geoghegan, Vannakambadi K. Ganesh et al. · Nature Reviews Microbiology | 16 Dec 2013 | 1,571 |
| 40 | Pathways and mechanisms of endocytic recycling Barth D. Grant, Julie G. Donaldson · Nature Reviews Molecular Cell Biology | 21 Aug 2009 | 1,504 |
| 41 | X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death Steven W. Muchmore, Michael Sattler, Heng Liang et al. · Nature | May 1996 | 1,475 |
| 42 | Bacterial Adherence: Adhesin-Receptor Interactions Mediating the Attachment of Bacteria to Mucosal Surfaces E. H. Beachey · The Journal of Infectious Diseases | Mar 1981 | 1,429 |
| 43 | Pathogenicity and virulence of Staphylococcus aureus Gordon Y. C. Cheung, Justin S. Bae, Michael J. Otto · Virulence | 31 Jan 2021 | 1,401 |
| 44 | Nanoconfinement controls stiffness, strength and mechanical toughness of β-sheet crystals in silk Sinan Keten, Zhi Ping Xu, Britni Ihle et al. · Nature Materials | 14 Mar 2010 | 1,395 |
| 45 | A peptide antibiotic from human skin Jürgen Harder, Joachim Bartels, Enno Christophers et al. · Nature | 26 Jun 1997 | 1,373 |
| 46 | Diversity of antimicrobial peptides and their mechanisms of action Richard M. Epand, Hans J. Vogel · Biochimica et Biophysica Acta (BBA) - Biomembranes | Dec 1999 | 1,364 |
| 47 | Antimicrobial Peptides Ali Adem Bahar, Dacheng Ren · Pharmaceuticals | 28 Nov 2013 | 1,355 |
| 48 | Cationic peptides: a new source of antibiotics Robert E. W. Hancock, Robert I. Lehrer · Trends in biotechnology | Feb 1998 | 1,345 |
| 49 | Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic Jürgen Harder, Joachim Bartels, Enno Christophers et al. · Journal of Biological Chemistry | Feb 2001 | 1,316 |
| 50 | Crystal Structure of the Extracellular Segment of Integrin αVβ3 Jian-Ping Xiong, Thilo Stehle, Beate Diefenbach et al. · Science | 12 Oct 2001 | 1,285 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.