Most cited papers in Biomedical Research and Pathophysiology
What are the most cited papers in Biomedical Research and Pathophysiology?
The most cited paper in Biomedical Research and Pathophysiology is "Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?" (Thomas Grobner, 2006), with 1,856 citations. Next come "Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury" (1,749) and "The return of metabolism: biochemistry and physiology of the pentose phosphate pathway" (1,621).
Showing 50 of 99 papers. Every paper with more than 464 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas Grobner · Nephrology Dialysis Transplantation | 23 Jan 2006 | 1,856 |
| 2 | Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury Jaya Mishra, Qing Ma, Anne E. Prada et al. · Journal of the American Society of Nephrology | Oct 2003 | 1,749 |
| 3 | The return of metabolism: biochemistry and physiology of the pentose phosphate pathway Anna Stincone, Alessandro Prigione, Thorsten Cramer et al. · Biological reviews/Biological reviews of the Cambridge Philosophical Society | 22 Sep 2014 | 1,621 |
| 4 | Termination of autophagy and reformation of lysosomes regulated by mTOR Li Yu, Christina K. McPhee, Lixin Zheng et al. · Nature | Jun 2010 | 1,596 |
| 5 | Safety and Efficacy of Recombinant Human α-Galactosidase A Replacement Therapy in Fabry's Disease Christine M. Eng, Nathalie Guffon, William Ross Wilcox et al. · New England Journal of Medicine | 5 Jul 2001 | 1,559 |
| 6 | Time trends in reported prevalence of kidney stones in the United States: 1976–199411.See Editorial by Goldfarb, p. 1951. Kiriaki Stamatelou, Mildred E. Francis, Camille A. Jones et al. · Kidney International | May 2003 | 1,471 |
| 7 | Diversity of group types, regulation, and function of phospholipase A2. Edward A. Dennis · Journal of Biological Chemistry | May 1994 | 1,442 |
| 8 | Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease Tamara Isakova, on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group, PATRICIA W. WAHL et al. · Kidney International | 9 Mar 2011 | 1,264 |
| 9 | LIPID NEPHROTOXICITY IN CHRONIC PROGRESSIVE GLOMERULAR AND TUBULO-INTERSTITIAL DISEASE J F Moorhead, M. El-Nahas, Man Kam Chan et al. · The Lancet | Dec 1982 | 1,079 |
| 10 | Enzymatic Defect in Fabry's Disease Roscoe O. Brady, Andrew E. Gal, Roy M. Bradley et al. · New England Journal of Medicine | 25 May 1967 | 1,066 |
| 11 | Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation Ira J. Fox, Jayanta Roy Chowdhury, Stuart S. Kaufman et al. · New England Journal of Medicine | 14 May 1998 | 1,041 |
| 12 | Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria Loris Borghi, Tania Schianchi, Tiziana Meschi et al. · New England Journal of Medicine | 10 Jan 2002 | 1,039 |
| 13 | The many functions of ESCRTs Marina Vietri, Maja Radulovic, Harald Stenmark · Nature Reviews Molecular Cell Biology | 8 Nov 2019 | 1,004 |
| 14 | Renal tubule injury: a driving force toward chronic kidney disease Bi‐Cheng Liu, Tao‐Tao Tang, Lin‐Li Lv et al. · Kidney International | 17 Jan 2018 | 955 |
| 15 | Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease) Ichizo Nishino, Jin Fu, Kurenai Tanji et al. · Nature | Aug 2000 | 955 |
| 16 | Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia Stefan Bröer · Physiological Reviews | 2008 | 955 |
| 17 | The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia Bradley K. Yoder, Xiaoying Hou, Lisa M. Guay‐Woodford · Journal of the American Society of Nephrology | Oct 2002 | 951 |
| 18 | Urinary Volume, Water and Recurrences in Idiopathic Calcium Nephrolithiasis: A 5-year Randomized Prospective Study Loris Borghi, Tiziana Meschi, Ferdinando Amato et al. · The Journal of Urology | Mar 1996 | 932 |
| 19 | Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease Orlando M. Gutiérrez, Tamara Isakova, Eugene P. Rhee et al. · Journal of the American Society of Nephrology | 25 May 2005 | 921 |
| 20 | Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice Yoshitaka Tanaka, Gundula Guhde, Anke Suter et al. · Nature | Aug 2000 | 915 |
| 21 | Fabry disease defined: baseline clinical manifestations of 366 patients in the Fabry Outcome Survey Atul B Mehta, Renato Pietro Ricci, Urs Widmer et al. · European Journal of Clinical Investigation | Mar 2004 | 860 |
| 22 | Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium Helle A. Prætorius, K. R. Spring · The Journal of Membrane Biology | Nov 2001 | 829 |
| 23 | Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents Kazushige Hanaoka, Feng Qian, Alessandra Boletta et al. · Nature | Dec 2000 | 821 |
| 24 | Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil Shideh Pouria, Armèle Dornelas de Andrade, José Etham de Lucena Barbosa et al. · The Lancet | Jul 1998 | 820 |
| 25 | Polycystic Kidney Disease Peter Christian Harris, Vicente E. Torres · Annual Review of Medicine | 23 Oct 2008 | 812 |
| 26 | The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease Jonathan M. Shillingford, Noel S. Murcia, Claire H. Larson et al. · Proceedings of the National Academy of Sciences | 27 Mar 2006 | 807 |
| 27 | Kidney stone disease F. L. Coe · Journal of Clinical Investigation | Oct 2005 | 799 |
| 28 | First Clinical Experience with Extracorporeally Induced Destruction of Kidney Stones by Shock Waves CHRISTIAN G. CHAUSSY, EGBERT SCHMIEDT, Bieter Jocham et al. · The Journal of Urology | Mar 1982 | 779 |
| 29 | Cystatin C as a marker of GFR—history, indications, and future research Guido Filler, Arend Bökenkamp, Walter J Hofmann et al. · Clinical Biochemistry | 15 Dec 2004 | 749 |
| 30 | Elevated globotriaosylsphingosine is a hallmark of Fabry disease Johannes M. F. G. Aerts, J.E.M. Groener, Sijmen Kuiper et al. · Proceedings of the National Academy of Sciences | 19 Feb 2008 | 735 |
| 31 | New functions of Müller cells Andreas Reichenbach, Andreas Bringmann · Glia | 26 Feb 2013 | 735 |
| 32 | Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits Gordon F. Rushworth, Ian L. Megson · Pharmacology & Therapeutics | 28 Sep 2013 | 733 |
| 33 | Metaanalysis of the relative nephrotoxicity of high- and low-osmolality iodinated contrast media. Brendan J. Barrett, Euan Carlisle · Radiology | Jul 1993 | 730 |
| 34 | Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival Robert C. Stanton · IUBMB Life | 20 Mar 2012 | 722 |
| 35 | Polycystin-2 is an intracellular calcium release channel Peter Koulen, Yiqiang Cai, Lin Geng et al. · Nature Cell Biology | 18 Feb 2002 | 718 |
| 36 | CATs and HATs: the SLC7 family of amino acid transporters François Verrey, Ellen Ildicho Closs, Carsten Alexander Wagner et al. · Pflügers Archiv - European Journal of Physiology | Feb 2004 | 718 |
| 37 | Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome Stephen J. Ansley, José Luis Badano, Oliver E. Blacque et al. · Nature | 21 Sep 2003 | 703 |
| 38 | Cystinosis William A. Gahl, Jess G. Thoene, Jerry A. Schneider · New England Journal of Medicine | 11 Jul 2002 | 700 |
| 39 | Fibroblast Growth Factor 23 (FGF23) Predicts Progression of Chronic Kidney Disease Danilo Fliser, Barbara Kollerits, Ulrich Neyer et al. · Journal of the American Society of Nephrology | 26 Jul 2007 | 698 |
| 40 | SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 Manuele Rebsamen, Lorena Pochini, Taras Stasyk et al. · Nature | 5 Jan 2015 | 692 |
| 41 | Screening Newborns for Inborn Errors of Metabolism by Tandem Mass Spectrometry Bridget M Wilcken, Veronica C. Wiley, Judith W. Hammond et al. · New England Journal of Medicine | 5 Jun 2003 | 691 |
| 42 | Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages Etienne M. Gagnon, Sophie Duclos, Christiane Rondeau et al. · Cell | Jul 2002 | 683 |
| 43 | Enzyme-Replacement Therapy in Mucopolysaccharidosis I Emil Kakkis, Joseph Muenzer, George E. Tiller et al. · New England Journal of Medicine | 18 Jan 2001 | 676 |
| 44 | A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake Laxminarayana R. Devireddy, Claude Gazin, Xiaochun Zhu et al. · Cell | Dec 2005 | 674 |
| 45 | Podocyte Biology and Response to Injury Peter H. Mundel, Stuart J. Shankland · Journal of the American Society of Nephrology | Dec 2002 | 671 |
| 46 | At the acidic edge: emerging functions for lysosomal membrane proteins Eeva‐Liisa Eskelinen, Yoshitaka Tanaka, Paul Säftig · Trends in Cell Biology | Mar 2003 | 664 |
| 47 | Apoptosis and acute kidney injury Andrea Havasi, Steven C. Borkan · Kidney International | 11 May 2011 | 661 |
| 48 | Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc − cystine transporter: a new action for an old drug PW Gout, AR Buckley, CR Simms et al. · Leukemia | Oct 2001 | 656 |
| 49 | Phototherapy for Neonatal Jaundice M. Jeffrey Maisels, Antony F. McDonagh · New England Journal of Medicine | 27 Feb 2008 | 654 |
| 50 | The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Richard E. Gilbert, Mark E. Cooper · Kidney International | Nov 1999 | 651 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.