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Topic · Pathology and Forensic Medicine

Biomedical Research and Pathophysiology

Biomedical Research and Pathophysiology is a research topic within Pathology and Forensic Medicine. Science Explorer counts 14k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on nephropathic cystinosis, a rare genetic lysosomal storage disorder. The research covers various aspects including the pathogenesis, treatment with cysteamine therapy, complications in multiple organs (especially renal and ocular), molecular genetics involving CTNS gene mutations, and the impact on cellular processes such as autophagy and mitochondrial function.

  • Cystinosis
  • Cysteamine Therapy
  • Lysosomal Dysfunction
  • Pentose Phosphate Pathway
  • CTNS Gene Mutations
  • Renal Complications
  • Ocular Manifestations
  • Autophagy Impairment
  • Transaldolase Deficiency
  • Mitochondrial Dysfunction
Research works
14k
fractional, since 1950
In the world top 10%
1.4k
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+10%
the tick is no change
Largest producer
United States
31% of the 10 largest, 2022-now
Biomedical Research and Pathophysiology

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Biomedical Research and Pathophysiology research?

By volume, the United States and China publish the most (444 and 292 works in 2022-now).

By volume, 2022-now

  1. 1 United States 444 works
  2. 2 China 292 works
  3. 3 India 142 works
  4. 4 Germany 94 works
  5. 5 Japan 91 works
  6. 6 Italy 82 works
  7. 7 Brazil 75 works
  8. 8 United Kingdom 73 works
  9. 9 France 70 works
  10. 10 Türkiye 68 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 31.0%China: 20.4%India: 9.9%Germany: 6.6%6 others listed: 32.1%31%largest
United States444 · 31.0%China292 · 20.4%India142 · 9.9%Germany94 · 6.6%6 others listed459 · 32.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Biomedical Research and Pathophysiology research?

By volume in 2022-now, Mayo Clinic publishes the most Biomedical Research and Pathophysiology research, followed by Harvard University and All India Institute of Medical Sciences.

By volume, 2022-now

  1. 1 Mayo ClinicUnited States 16 works
  2. 2 Harvard UniversityUnited States 15 works
  3. 3 All India Institute of Medical SciencesIndia 13 works
  4. 4 InsermFrance 12 works
  5. 5 Zhejiang UniversityChina 11 works
  6. 6 Shanghai Jiao Tong UniversityChina 10 works
  7. 7 Centre National de la Recherche ScientifiqueFrance 10 works
  8. 8 University College LondonUnited Kingdom 10 works
  9. 9 Capital Medical UniversityChina 10 works
  10. 10 National Institutes of HealthUnited States 8 works

Who are the leading researchers in Biomedical Research and Pathophysiology?

The most-cited researchers publishing on Biomedical Research and Pathophysiology include Shizuo Akira, Giuseppe Remuzzi and Gordon Henry Guyatt.

  1. 1 Shizuo Akira Japan 342k citations
  2. 2 Giuseppe Remuzzi Italy 328k citations
  3. 3 Gordon Henry Guyatt Canada 315k citations
  4. 4 Richard A. Gibbs United States 292k citations
  5. 5 Jean‐Louis Vincent Belgium 262k citations
  6. 6 Hans C. Clevers Netherlands 260k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Biomedical Research and Pathophysiology?

The most cited paper in Biomedical Research and Pathophysiology is "Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?" (Thomas Grobner, 2006), with 1,856 citations. Next come "Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury" (1,749) and "The return of metabolism: biochemistry and physiology of the pentose phosphate pathway" (1,621).

Most cited papers
#PaperReleasedCitations
1 Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas Grobner · Nephrology Dialysis Transplantation 23 Jan 2006 1,856
2 Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury Jaya Mishra, Qing Ma, Anne E. Prada et al. · Journal of the American Society of Nephrology Oct 2003 1,749
3 The return of metabolism: biochemistry and physiology of the pentose phosphate pathway Anna Stincone, Alessandro Prigione, Thorsten Cramer et al. · Biological reviews/Biological reviews of the Cambridge Philosophical Society ReviewOpen access 22 Sep 2014 1,621
4 Termination of autophagy and reformation of lysosomes regulated by mTOR Li Yu, Christina K. McPhee, Lixin Zheng et al. · Nature Open access Jun 2010 1,596
5 Safety and Efficacy of Recombinant Human α-Galactosidase A Replacement Therapy in Fabry's Disease Christine M. Eng, Nathalie Guffon, William Ross Wilcox et al. · New England Journal of Medicine Open access 5 Jul 2001 1,559
All 99 most cited papers, with filters and sorting

Where is Biomedical Research and Pathophysiology research done?

The largest centres of Biomedical Research and Pathophysiology research in 2022-now are Beijing (China), Paris (France), Shanghai (China) and Tokyo (Japan).

Largest cities, 2022-now

  1. 1 BeijingChina 38 works
  2. 2 ParisFrance 33 works
  3. 3 ShanghaiChina 31 works
  4. 4 TokyoJapan 25 works
  5. 5 LondonUnited Kingdom 24 works
  6. 6 São PauloBrazil 22 works
  7. 7 MadridSpain 21 works
  8. 8 New YorkUnited States 21 works
  9. 9 MoscowRussia 19 works
  10. 10 RomeItaly 17 works
See Biomedical Research and Pathophysiology on the map

Where is the best place to study Biomedical Research and Pathophysiology?

Among universities, judged by research, Harvard University, University College London and Zhejiang University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 11.3333%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversityShanghai Jiao Tong U…Zhejiang UniversityUniversity College L…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 88.818.3%2.6×15 +23.8%
2University College LondonUnited Kingdom 46.211.9%3.5×10 -6.0%
3Zhejiang UniversityChina 44.914.3%2.3×11 +98.3%
4Shanghai Jiao Tong UniversityChina 43.817.1%2.0×10 +101.2%
5All India Institute of Medical SciencesIndia 43.52.0%6.8×14 +102.7%
6Capital Medical UniversityChina 25.64.4%5.1×10 +38.2%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Biomedical Research and Pathophysiology, country by country

Is Biomedical Research and Pathophysiology research growing?

Output in 2022-2025 was 10% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Biomedical Research and Pathophysiology.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Biomedical Research and Pathophysiology as a percentage of every work published that year, 0.0092% in 2024.

still counting0.020%0.040%Biomedical Research and Pathophysiology0.0088% in 202519801990200020102020

Fractional works of Biomedical Research and Pathophysiology over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Biomedical Research and Pathophysiology10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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