Science Explorer Back to mapMap
Discussion
Topic · Pathology and Forensic Medicine

Cardiac Ischemia and Reperfusion

Cardiac Ischemia and Reperfusion is a research topic within Pathology and Forensic Medicine. Science Explorer counts 33k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the pathophysiology, mechanisms, and therapeutic strategies related to myocardial reperfusion injury, including ischemic preconditioning, remote ischemic conditioning, oxidative stress, and the role of mitochondrial permeability transition pore. It also explores the involvement of various cell signaling pathways and reactive oxygen species in the context of cardioprotection and myocardial infarction.

  • Ischemia-Reperfusion Injury
  • Cardioprotection
  • Mitochondrial Permeability Transition Pore
  • Oxidative Stress
  • Ischemic Preconditioning
  • Remote Ischemic Conditioning
  • Reactive Oxygen Species
  • Myocardial Infarction
  • ATP-Sensitive Potassium Channels
  • Cell Signaling Pathways
Research works
33k
fractional, since 1950
In the world top 10%
3.3k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-9%
the tick is no change
Largest producer
China
40% of the 10 largest, 2022-now
Cardiac Ischemia and Reperfusion

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cardiac Ischemia and Reperfusion research?

By volume, China and the United States publish the most (981 and 661 works in 2022-now).

By volume, 2022-now

  1. 1 China 981 works
  2. 2 United States 661 works
  3. 3 Germany 140 works
  4. 4 Türkiye 111 works
  5. 5 Japan 110 works
  6. 6 India 107 works
  7. 7 Russia 102 works
  8. 8 United Kingdom 91 works
  9. 9 Italy 73 works
  10. 10 Iran 72 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 40.1%United States: 27.0%Germany: 5.7%Türkiye: 4.5%6 others listed: 22.7%40%largest
China981 · 40.1%United States661 · 27.0%Germany140 · 5.7%Türkiye111 · 4.5%6 others listed555 · 22.7%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cardiac Ischemia and Reperfusion research?

By volume in 2022-now, Russian Academy of Sciences publishes the most Cardiac Ischemia and Reperfusion research, followed by Capital Medical University and Harvard University.

By volume, 2022-now

  1. 1 Russian Academy of SciencesRussia 38 works
  2. 2 Capital Medical UniversityChina 37 works
  3. 3 Harvard UniversityUnited States 27 works
  4. 4 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 26 works
  5. 5 Shanghai Jiao Tong UniversityChina 22 works
  6. 6 Nanjing Medical UniversityChina 21 works
  7. 7 Wuhan UniversityChina 20 works
  8. 8 Sichuan UniversityChina 17 works
  9. 9 Sun Yat-sen UniversityChina 16 works
  10. 10 InsermFrance 16 works

Who are the leading researchers in Cardiac Ischemia and Reperfusion?

The most-cited researchers publishing on Cardiac Ischemia and Reperfusion include Mark J. Daly, Guido Kroemer and John J.V. McMurray.

  1. 1 Mark J. Daly United States 403k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 John J.V. McMurray United Kingdom 349k citations
  4. 4 Shizuo Akira Japan 342k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Stephan Windecker Switzerland 338k citations
  7. 7 Giuseppe Remuzzi Italy 328k citations
  8. 8 Gordon Henry Guyatt Canada 315k citations
  9. 9 Gregory Y.H. Lip United Kingdom 311k citations
  10. 10 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cardiac Ischemia and Reperfusion?

The most cited paper in Cardiac Ischemia and Reperfusion is "Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium." (Charles E. Murry, Robert B. Jennings, K A Reimer, 1986), with 7,857 citations. Next come "Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release" (5,423) and "Myocardial Reperfusion Injury" (3,755).

Most cited papers
#PaperReleasedCitations
1 Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Charles E. Murry, Robert B. Jennings, K A Reimer · Circulation Open access Nov 1986 7,857
2 Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release Dmitry B. Zorov, Magdalena Juhaszova, Steven J. Sollott · Physiological Reviews ReviewOpen access Jul 2014 5,423
3 Myocardial Reperfusion Injury Derek M. Yellon, Derek John Hausenloy · New England Journal of Medicine 12 Sep 2007 3,755
4 BCL-2 family members and the mitochondria in apoptosis Atan Gross, James M. McDonnell, S J Korsmeyer · Genes & Development Open access Aug 1999 3,664
5 Ischemia and reperfusion—from mechanism to translation Holger K. Eltzschig, Tobias de la Garza Eckle · Nature Medicine Open access Nov 2011 3,427
All 99 most cited papers, with filters and sorting

Where is Cardiac Ischemia and Reperfusion research done?

The largest centres of Cardiac Ischemia and Reperfusion research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China).

Largest cities, 2022-now

  1. 1 BeijingChina 134 works
  2. 2 ShanghaiChina 67 works
  3. 3 GuangzhouChina 61 works
  4. 4 WuhanChina 43 works
  5. 5 NanjingChina 37 works
  6. 6 HangzhouChina 31 works
  7. 7 MoscowRussia 31 works
  8. 8 BostonUnited States 31 works
  9. 9 ChengduChina 29 works
  10. 10 TokyoJapan 27 works
See Cardiac Ischemia and Reperfusion on the map

Where is the best place to study Cardiac Ischemia and Reperfusion?

Among universities, judged by research, Harvard University, Wuhan University and Chinese Academy of Medical Sciences & Peking Union Medical College score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.99%fractional works in this field (log) →share of work in the world top 10% →Wuhan UniversityChinese Academy of M…Harvard UniversityCapital Medical Univ…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 67.912.1%3.0×27 +14.5%
2Wuhan UniversityChina 66.835.3%5.0×20 -35.8%
3Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 66.218.7%8.4×26 +25.7%
4Capital Medical UniversityChina 66.111.5%12.1×37 +22.2%
5Southern Medical UniversityChina 60.721.1%8.9×16 +11.3%
6Chiang Mai UniversityThailand 58.714.4%10.5×10 +49.0%
7Washington University in St. LouisUnited States 55.014.4%6.1×13 +53.5%
8Brown UniversityUnited States 54.219.6%7.8×11 +46.2%
9Soochow UniversityChina 53.625.5%4.7×13 -13.7%
10Shanghai Jiao Tong UniversityChina 51.317.3%2.6×22 -2.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cardiac Ischemia and Reperfusion, country by country

Is Cardiac Ischemia and Reperfusion research growing?

Output in 2022-2025 was 9% lower than in 2018-2021, peaking in 2008.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cardiac Ischemia and Reperfusion as a percentage of every work published that year, 0.013% in 2024.

still counting0.050%0.10%Cardiac Ischemia and Reperfusion0.014% in 202519801990200020102020

Fractional works of Cardiac Ischemia and Reperfusion over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cardiac Ischemia and Reperfusion9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

Ask a question or share a note about Cardiac Ischemia and Reperfusion. Posts are plain text and can be reported.