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Topic · Pathology and Forensic Medicine

Whipple's Disease and Interleukins

Whipple's Disease and Interleukins is a research topic within Pathology and Forensic Medicine. Science Explorer counts 5.1k research works in it since 1950. 10.6% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the pathogenesis, diagnosis, and treatment of Whipple's disease, caused by the bacterium Tropheryma whipplei. It covers topics such as bacterial cultivation, genome sequencing, interleukin-16 involvement, central nervous system manifestations, PCR diagnosis, microbial susceptibility to antibiotics, and the immune reconstitution inflammatory syndrome. The research also delves into the association of Whipple's disease with immunosuppressive therapy and explores potential genetic biomarkers for disease susceptibility.

  • Whipple's Disease
  • Tropheryma whipplei
  • Interleukin-16
  • Bacterial Cultivation
  • Genome Sequencing
  • Immunosuppressive Therapy
  • Central Nervous System Involvement
  • PCR Diagnosis
  • Microbial Susceptibility
  • Immune Reconstitution Inflammatory Syndrome
Research works
5.1k
fractional, since 1950
In the world top 10%
539
per year above
Top-10% rate
10.6%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+13%
the tick is no change
Largest producer
United States
29% of the 10 largest, 2022-now
Whipple's Disease and Interleukins

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Whipple's Disease and Interleukins research?

By volume, the United States and China publish the most (202 and 156 works in 2022-now).

By volume, 2022-now

  1. 1 United States 202 works
  2. 2 China 156 works
  3. 3 Germany 56 works
  4. 4 India 51 works
  5. 5 Brazil 50 works
  6. 6 Italy 48 works
  7. 7 France 43 works
  8. 8 United Kingdom 35 works
  9. 9 Spain 26 works
  10. 10 Japan 24 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 29.2%China: 22.6%Germany: 8.1%India: 7.3%6 others listed: 32.8%29%largest
United States202 · 29.2%China156 · 22.6%Germany56 · 8.1%India51 · 7.3%6 others listed226 · 32.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Whipple's Disease and Interleukins research?

By volume in 2022-now, Mayo Clinic publishes the most Whipple's Disease and Interleukins research, followed by Harvard University and Sichuan University.

By volume, 2022-now

  1. 1 Mayo ClinicUnited States 10 works
  2. 2 Harvard UniversityUnited States 6 works
  3. 3 Sichuan UniversityChina 5 works
  4. 4 Zhejiang UniversityChina 5 works
  5. 5 InsermFrance 5 works
  6. 6 Nanjing Medical UniversityChina 5 works
  7. 7 All India Institute of Medical SciencesIndia 5 works
  8. 8 Université Paris CitéFrance 5 works
  9. 9 Universidade de São PauloBrazil 4 works
  10. 10 Ludwig-Maximilians-Universität MünchenGermany 4 works

Who are the leading researchers in Whipple's Disease and Interleukins?

The most-cited researchers publishing on Whipple's Disease and Interleukins include Hermann Brenner, Reza Malekzadeh and Michael Karin.

  1. 1 Hermann Brenner Germany 343k citations
  2. 2 Reza Malekzadeh Iran 278k citations
  3. 3 Michael Karin United States 276k citations
  4. 4 Kaj Blennow Sweden 247k citations
  5. 5 Dennis W. Dickson United States 237k citations
  6. 6 Richard Anthony Flavell United States 237k citations
  7. 7 Aviv Regev United States 236k citations
  8. 8 Didier Raoult France 232k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Whipple's Disease and Interleukins?

The most cited paper in Whipple's Disease and Interleukins is "The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells" (Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al., 2006), with 5,186 citations. Next come "Functional Bowel Disorders" (4,801) and "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17" (4,286).

Most cited papers
#PaperReleasedCitations
1 The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell Open access Sep 2006 5,186
2 Functional Bowel Disorders George F. Longstreth, Wade Thompson, William D. Chey et al. · Gastroenterology Apr 2006 4,801
3 A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology 2 Oct 2005 4,286
4 Transforming growth factor-β induces development of the TH17 lineage Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature 30 Apr 2006 3,074
5 IL-6 as a keystone cytokine in health and disease Christopher A. Hunter, Simon A. Jones · Nature Immunology 21 Apr 2015 2,555
All 100 most cited papers, with filters and sorting

Where is Whipple's Disease and Interleukins research done?

The largest centres of Whipple's Disease and Interleukins research in 2022-now are Beijing (China), Paris (France), London (United Kingdom) and São Paulo (Brazil).

Largest cities, 2022-now

  1. 1 BeijingChina 16 works
  2. 2 ParisFrance 15 works
  3. 3 LondonUnited Kingdom 12 works
  4. 4 São PauloBrazil 11 works
  5. 5 MadridSpain 9 works
  6. 6 RomeItaly 9 works
  7. 7 New YorkUnited States 9 works
  8. 8 HangzhouChina 9 works
  9. 9 GuangzhouChina 9 works
  10. 10 JinanChina 8 works
See Whipple's Disease and Interleukins on the map

Is Whipple's Disease and Interleukins research growing?

Output in 2022-2025 was 13% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Whipple's Disease and Interleukins.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Whipple's Disease and Interleukins as a percentage of every work published that year, 0.0038% in 2024.

still counting0.0050%0.010%Whipple's Disease and Interleukins0.0047% in 202519801990200020102020

Fractional works of Whipple's Disease and Interleukins over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Whipple's Disease and Interleukins10.1% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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