Most cited papers in Whipple's Disease and Interleukins
What are the most cited papers in Whipple's Disease and Interleukins?
The most cited paper in Whipple's Disease and Interleukins is "The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells" (Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al., 2006), with 5,186 citations. Next come "Functional Bowel Disorders" (4,801) and "A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17" (4,286).
Showing 50 of 100 papers. Every paper with more than 480 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell | Sep 2006 | 5,186 |
| 2 | Functional Bowel Disorders George F. Longstreth, Wade Thompson, William D. Chey et al. · Gastroenterology | Apr 2006 | 4,801 |
| 3 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology | 2 Oct 2005 | 4,286 |
| 4 | Transforming growth factor-β induces development of the TH17 lineage Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature | 30 Apr 2006 | 3,074 |
| 5 | IL-6 as a keystone cytokine in health and disease Christopher A. Hunter, Simon A. Jones · Nature Immunology | 21 Apr 2015 | 2,555 |
| 6 | Interleukin-17 Family Members and Inflammation Jay K. Kolls, Anders Lindén · Immunity | Oct 2004 | 2,386 |
| 7 | IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Liang Zhou, Ivaylo I. Ivanov, Rosanne J. Spolski et al. · Nature Immunology | 20 Jun 2007 | 2,166 |
| 8 | Classification of Inflammatory Bowel Disease J E Lennard‐Jones · Scandinavian Journal of Gastroenterology | 1989 | 2,046 |
| 9 | Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17 Sudeepta Aggarwal, Nico Ghilardi, Ming-Hong Xie et al. · Journal of Biological Chemistry | 2003 | 1,860 |
| 10 | IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells Thomas Korn, Estelle Bettelli, Wenda Gao et al. · Nature | 20 Jun 2007 | 1,856 |
| 11 | IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages Casey Todd Weaver, Robin D. Hatton, Paul R. Mangan et al. · Annual Review of Immunology | 13 Jan 2007 | 1,855 |
| 12 | The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation Wenjun Ouyang, Jay K. Kolls, Yan Zheng · Immunity | Apr 2008 | 1,698 |
| 13 | Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation Craig A. Murphy, Claire L. Langrish, Yi Chen et al. · The Journal of Experimental Medicine | 8 Dec 2003 | 1,665 |
| 14 | Innate IL-17-producing cells: the sentinels of the immune system Daniel J. Cua, Cristina M. Tato · Nature reviews. Immunology | 18 Jun 2010 | 1,587 |
| 15 | IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis Yutaka Komiyama, Susumu Nakae, Taizo Matsuki et al. · The Journal of Immunology | Jul 2006 | 1,548 |
| 16 | THE PHENOMENON OF THE ACUTE PHASE RESPONSE* Irving Kushner · Annals of the New York Academy of Sciences | Jun 1982 | 1,503 |
| 17 | Structure and signalling in the IL-17 receptor family Sarah L. Gaffen · Nature reviews. Immunology | 3 Jul 2009 | 1,483 |
| 18 | The IL-17 Family of Cytokines in Health and Disease Mandy J. McGeachy, Daniel J. Cua, Sarah L. Gaffen · Immunity | Apr 2019 | 1,480 |
| 19 | Vitamin D and the Immune System Cynthia B. Aranow · Journal of Investigative Medicine | Aug 2011 | 1,449 |
| 20 | Interleukin-17 and Type 17 Helper T Cells Pierre Miossec, Thomas Korn, Vijay Kumar Kuchroo · New England Journal of Medicine | 26 Aug 2009 | 1,420 |
| 21 | Functional Specialization of Interleukin-17 Family Members Yoichiro Iwakura, Harumichi Ishigame, Shinobu Saijo et al. · Immunity | Feb 2011 | 1,308 |
| 22 | A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R Christi L. Parham et al. · The Journal of Immunology | Jun 2002 | 1,302 |
| 23 | A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity Marina Cella, Anja G. Fuchs, William Vermi et al. · Nature | 2 Nov 2008 | 1,241 |
| 24 | Induction and molecular signature of pathogenic TH17 cells Youjin Lee, Amit Awasthi, Nir Yosef et al. · Nature Immunology | 9 Sep 2012 | 1,199 |
| 25 | Identification of the Uncultured Bacillus of Whipple’s Disease David A. Relman, Thomas Mitchell Schmidt, Richard P. MacDermott et al. · New England Journal of Medicine | 30 Jul 1992 | 1,156 |
| 26 | Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology Sofia M. Buonocore, Philip P. Ahern, Holm H. Uhlig et al. · Nature | Apr 2010 | 1,073 |
| 27 | Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity Wenjing Yang, Tianming Yu, Xiangsheng Huang et al. · Nature Communications | 8 Sep 2020 | 1,064 |
| 28 | The IL-23/IL-17 axis in inflammation Yoichiro Iwakura · Journal of Clinical Investigation | May 2006 | 1,063 |
| 29 | STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing Geethanjali Pickert, Clemens Neufert, Moritz Leppkes et al. · The Journal of Experimental Medicine | 29 Jun 2009 | 1,056 |
| 30 | Gastric cancer and Helicobacter pylori : a combined analysis of 12 case control studies nested within prospective cohorts Helicobacter and Cancer Collaborative Group · Gut | Sep 2001 | 1,050 |
| 31 | The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease Leslie T. Cooper, Kenneth Lee Baughman, Arthur M. Feldman et al. · Circulation | 24 Oct 2007 | 1,033 |
| 32 | Postinfectious Irritable Bowel Syndrome Robert E. Spiller, Klara C. Garsed · Gastroenterology | May 2009 | 1,026 |
| 33 | Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 Chuan Wu, Nir Yosef, Theresa Thalhamer et al. · Nature | 5 Mar 2013 | 1,026 |
| 34 | Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses Harumichi Ishigame, Shigeru Kakuta, Takeshi Nagai et al. · Immunity | 2009 | 1,021 |
| 35 | IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis Ken Sugimoto, Atsuhiro Ogaẃa, Emiko Mizoguchi et al. · Journal of Clinical Investigation | 2 Jan 2008 | 1,021 |
| 36 | IL-17 and IL-17-producing cells in protection versus pathology Kingston H. G. Mills · Nature reviews. Immunology | 5 Jul 2022 | 1,017 |
| 37 | A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis Caroline E. Sutton, Corinna F. Brereton, Brian Keogh et al. · The Journal of Experimental Medicine | 3 Jul 2006 | 1,015 |
| 38 | Helicobacter pylori infection induces gastric cancer in Mongolian gerbils Takeshi Watanabe, Mayumi Tada, Hirofumi Nagai et al. · Gastroenterology | Sep 1998 | 997 |
| 39 | Interleukin 15: biology and relevance to human disease Todd A. Fehniger, Michael A. Caligiuri · Blood | 2001 | 975 |
| 40 | Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer Jiaqing Huang, Subbaramiah Sridhar, Ying Chen et al. · Gastroenterology | Jun 1998 | 963 |
| 41 | A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain A Lee, Jani O’Rourke, Maria Corazon A. De Ungria et al. · Gastroenterology | Apr 1997 | 947 |
| 42 | A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses Elisabetta Volpe, Nicolas Servant, Raphaël Zollinger et al. · Nature Immunology | 4 May 2008 | 932 |
| 43 | Prevalence and Characteristics of Tinnitus among US Adults Josef Shargorodsky, Gary C. Curhan, Wildon R. Farwell · The American Journal of Medicine | 28 Jul 2010 | 924 |
| 44 | Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease Reiko M. Onishi, Sarah L. Gaffen · Immunology | 2 Feb 2010 | 904 |
| 45 | A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease Erik G. Puffenberger, Kiminori Hosoda, Sarah S. Washington et al. · Cell | Dec 1994 | 897 |
| 46 | IL-37 is a fundamental inhibitor of innate immunity Marcel F. Nold, Claudia A. Nold‐Petry, Jarod A. Zepp et al. · Nature Immunology | 10 Oct 2010 | 856 |
| 47 | New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions Christopher A. Hunter · Nature reviews. Immunology | Jul 2005 | 855 |
| 48 | Clinical features, diagnosis, and management of enterovirus 71 Mong How Ooi, See Chang Wong, Penny Lewthwaite et al. · The Lancet Neurology | 19 Oct 2010 | 839 |
| 49 | Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells Marcel Batten, Ji Li, Sothy Yi et al. · Nature Immunology | 13 Aug 2006 | 834 |
| 50 | Interleukin-23 drives innate and T cell–mediated intestinal inflammation Sophie Hüe, Philip P. Ahern, Sofia M. Buonocore et al. · The Journal of Experimental Medicine | 9 Oct 2006 | 829 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.