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Topic · Pathology and Forensic Medicine

Systemic Sclerosis and Related Diseases

Systemic Sclerosis and Related Diseases is a research topic within Pathology and Forensic Medicine. Science Explorer counts 36k research works in it since 1950. 10.4% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the pathogenesis, clinical manifestations, and treatment of systemic sclerosis, with an emphasis on fibrosis, autoantibodies, pulmonary involvement, and the role of TGF-ß signaling. It also explores genetic markers, endothelial dysfunction, and various treatment approaches including immunosuppressive therapy for this complex autoimmune disease.

  • Systemic Sclerosis
  • Fibrosis
  • Autoantibodies
  • Pulmonary Involvement
  • Treatment
  • Raynaud's Phenomenon
  • Genetic Markers
  • Endothelial Dysfunction
  • TGF-ß Signaling
  • Immunosuppressive Therapy
Research works
36k
fractional, since 1950
In the world top 10%
3.8k
per year above
Top-10% rate
10.4%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+27%
the tick is no change
Largest producer
United States
30% of the 10 largest, 2022-now
Systemic Sclerosis and Related Diseases

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Systemic Sclerosis and Related Diseases research?

By volume, the United States and China publish the most (1.7k and 826 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.7k works
  2. 2 China 826 works
  3. 3 Italy 572 works
  4. 4 United Kingdom 530 works
  5. 5 Japan 403 works
  6. 6 France 381 works
  7. 7 Germany 355 works
  8. 8 India 344 works
  9. 9 Spain 339 works
  10. 10 Türkiye 287 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 29.5%China: 14.4%Italy: 10.0%United Kingdom: 9.3%6 others listed: 36.8%30%largest
United States1,692 · 29.5%China826 · 14.4%Italy572 · 10.0%United Kingdom530 · 9.3%6 others listed2,110 · 36.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Systemic Sclerosis and Related Diseases research?

By volume in 2022-now, Harvard University publishes the most Systemic Sclerosis and Related Diseases research, followed by University College London and Inserm.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 79 works
  2. 2 University College LondonUnited Kingdom 55 works
  3. 3 InsermFrance 52 works
  4. 4 Johns Hopkins UniversityUnited States 50 works
  5. 5 Mayo ClinicUnited States 46 works
  6. 6 Université Paris CitéFrance 44 works
  7. 7 University of LeedsUnited Kingdom 42 works
  8. 8 University of MichiganUnited States 39 works
  9. 9 University of ZurichSwitzerland 38 works
  10. 10 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 35 works

Who are the leading researchers in Systemic Sclerosis and Related Diseases?

The most-cited researchers publishing on Systemic Sclerosis and Related Diseases include George Davey Smith, Mark J. Daly and John J.V. McMurray.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 John J.V. McMurray United Kingdom 349k citations
  4. 4 Cyrus Cooper United Kingdom 342k citations
  5. 5 Giuseppe Remuzzi Italy 328k citations
  6. 6 Matthias Egger Switzerland 326k citations
  7. 7 John P. A. Ioannidis United States 317k citations
  8. 8 Gordon Henry Guyatt Canada 315k citations
  9. 9 Gregory Y.H. Lip United Kingdom 311k citations
  10. 10 Matthias Mann Germany 308k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Systemic Sclerosis and Related Diseases?

The most cited paper in Systemic Sclerosis and Related Diseases is "APACHE II-A Severity of Disease Classification System" (William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al., 1986), with 13,426 citations. Next come "Evaluation of Diagnostic Criteria for Ankylosing Spondylitis" (5,762) and "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study" (5,057).

Most cited papers
#PaperReleasedCitations
1 APACHE II-A Severity of Disease Classification System William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine Aug 1986 13,426
2 Evaluation of Diagnostic Criteria for Ankylosing Spondylitis Sjef van der Linden, Hans A. Valkenburg, A. Cats · Arthritis & Rheumatism Apr 1984 5,762
3 Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study Hana Štorkánová, Sabína Oreská, Maja Špiritović et al. · Scientific Reports Open access 7 Jan 2021 5,057
4 Preliminary criteria for the classification of systemic sclerosis (scleroderma) Alfonse T. Masi · Arthritis & Rheumatism May 1980 4,957
5 Cellular and molecular mechanisms of fibrosis Thomas A. Wynn · The Journal of Pathology Open access 27 Dec 2007 4,557
All 98 most cited papers, with filters and sorting

Where is Systemic Sclerosis and Related Diseases research done?

The largest centres of Systemic Sclerosis and Related Diseases research in 2022-now are London (United Kingdom), Beijing (China), Paris (France) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Sousse and Brescia.

Largest cities, 2022-now

  1. 1 LondonUnited Kingdom 158 works
  2. 2 BeijingChina 154 works
  3. 3 ParisFrance 151 works
  4. 4 TokyoJapan 104 works
  5. 5 RomeItaly 100 works
  6. 6 MoscowRussia 100 works
  7. 7 New YorkUnited States 90 works
  8. 8 SeoulSouth Korea 85 works
  9. 9 BostonUnited States 81 works
  10. 10 ShanghaiChina 79 works

Where it is the local speciality

  1. SousseTN · 22.4 works13×
  2. BresciaIT · 24.3 works13×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Systemic Sclerosis and Related Diseases than the world average.

See Systemic Sclerosis and Related Diseases on the map

Where is the best place to study Systemic Sclerosis and Related Diseases?

Among universities, judged by research, Karolinska Institutet, Humanitas University and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 19.61%fractional works in this field (log) →share of work in the world top 10% →Humanitas UniversityKarolinska InstitutetUniversity of ZurichHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Karolinska InstitutetSweden 79.320.6%7.8×34 +36.4%
2Humanitas UniversityItaly 72.729.9%12.6×14 +308.4%
3Harvard UniversityUnited States 70.512.1%3.3×79 +48.7%
4University of ZurichSwitzerland 69.718.7%7.1×38 +6.0%
5Johns Hopkins UniversityUnited States 69.414.0%4.3×50 +21.0%
6University of LeedsUnited Kingdom 69.316.6%9.8×42 +24.9%
7University of MichiganUnited States 68.217.1%3.4×39 +27.5%
8University of PittsburghUnited States 67.222.6%3.1×18 +12.0%
9Vita-Salute San Raffaele UniversityItaly 66.921.0%18.4×18 +211.1%
10University of GroningenNetherlands 66.623.5%4.2×22 +16.0%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Systemic Sclerosis and Related Diseases, country by country

Is Systemic Sclerosis and Related Diseases research growing?

Output in 2022-2025 was 27% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Systemic Sclerosis and Related Diseases.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Systemic Sclerosis and Related Diseases as a percentage of every work published that year, 0.040% in 2024.

still counting0.020%0.040%0.060%Systemic Sclerosis and Related Diseases0.039% in 202519801990200020102020

Fractional works of Systemic Sclerosis and Related Diseases over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Systemic Sclerosis and Related Diseases10.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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