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Topic · Pathology and Forensic Medicine

Cancer Mechanisms and Therapy

Cancer Mechanisms and Therapy is a research topic within Pathology and Forensic Medicine. Science Explorer counts 20k research works in it since 1964. 10.4% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of Pim oncogenes, particularly Pim-1 and Pim-2 kinases, in promoting tumorigenesis, cancer progression, and metastasis. The cluster also explores the potential of targeting Pim kinases as a therapeutic approach, with a specific emphasis on their involvement in cell survival pathways, phosphorylation of key proteins, and their association with hematological malignancies.

  • Pim Oncogenes
  • Tumorigenesis
  • Metadherin
  • Astrocyte Elevated Gene-1
  • Kinase Inhibitors
  • Cancer Progression
  • Cell Survival Pathways
  • Phosphorylation
  • Metastasis
  • Hematological Malignancies
Research works
20k
fractional, since 1964
In the world top 10%
2.1k
per year above
Top-10% rate
10.4%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-7%
the tick is no change
Largest producer
China
55% of the 10 largest, 2022-now
Cancer Mechanisms and Therapy

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cancer Mechanisms and Therapy research?

By volume, China and the United States publish the most (2.2k and 766 works in 2022-now).

By volume, 2022-now

  1. 1 China 2.2k works
  2. 2 United States 766 works
  3. 3 India 241 works
  4. 4 Japan 154 works
  5. 5 South Korea 129 works
  6. 6 Italy 116 works
  7. 7 Germany 98 works
  8. 8 Egypt 86 works
  9. 9 Iran 79 works
  10. 10 Taiwan 76 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 55.4%United States: 19.6%India: 6.2%Japan: 3.9%6 others listed: 15.0%55%largest
China2,171 · 55.4%United States766 · 19.6%India241 · 6.2%Japan154 · 3.9%6 others listed586 · 15.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cancer Mechanisms and Therapy research?

By volume in 2022-now, Sun Yat-sen University publishes the most Cancer Mechanisms and Therapy research, followed by Nanjing Medical University and Sichuan University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 74 works
  2. 2 Nanjing Medical UniversityChina 45 works
  3. 3 Sichuan UniversityChina 44 works
  4. 4 Shanghai Jiao Tong UniversityChina 38 works
  5. 5 Fudan UniversityChina 37 works
  6. 6 Zhejiang UniversityChina 36 works
  7. 7 Central South UniversityChina 33 works
  8. 8 Harvard UniversityUnited States 32 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 32 works
  10. 10 Huazhong University of Science and TechnologyChina 32 works

Who are the leading researchers in Cancer Mechanisms and Therapy?

The most-cited researchers publishing on Cancer Mechanisms and Therapy include Stacey L. Gabriel, Guido Kroemer and Bert Vogelstein.

  1. 1 Stacey L. Gabriel United States 402k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Gad A. Getz United States 364k citations
  5. 5 Elaine R. Mardis United States 346k citations
  6. 6 Shizuo Akira Japan 342k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Todd R. Golub United States 283k citations
  10. 10 Matthew M. Meyerson United States 280k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cancer Mechanisms and Therapy?

The most cited paper in Cancer Mechanisms and Therapy is "The 2007 WHO Classification of Tumours of the Central Nervous System" (Hiroko Ohgaki, Otmar Dieter Wiestler, Webster K. Cavenee et al., 2007), with 14,012 citations. Next come "Mutations of the BRAF gene in human cancer" (10,791) and "Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma" (7,547).

Most cited papers
#PaperReleasedCitations
1 The 2007 WHO Classification of Tumours of the Central Nervous System Hiroko Ohgaki, Otmar Dieter Wiestler, Webster K. Cavenee et al. · Digital Access to Scholarship at Harvard (DASH) (Harvard University) Open access 2007 14,012
2 Mutations of the BRAF gene in human cancer Helen Ruth Davies et al. · Nature Jun 2002 10,791
3 Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma Richard S. Finn et al. · New England Journal of Medicine Open access 13 May 2020 7,547
4 Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis Vincenzo Mazzaferro, Enrico Regalia, Roberto Doci et al. · New England Journal of Medicine 14 Mar 1996 7,221
5 MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science 26 Apr 2007 4,504
All 100 most cited papers, with filters and sorting

Where is Cancer Mechanisms and Therapy research done?

The largest centres of Cancer Mechanisms and Therapy research in 2022-now are Shanghai (China), Beijing (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wenzhou.

Largest cities, 2022-now

  1. 1 ShanghaiChina 174 works
  2. 2 BeijingChina 166 works
  3. 3 GuangzhouChina 161 works
  4. 4 NanjingChina 94 works
  5. 5 HangzhouChina 84 works
  6. 6 WuhanChina 77 works
  7. 7 ChengduChina 74 works
  8. 8 SeoulSouth Korea 69 works
  9. 9 JinanChina 66 works
  10. 10 ChangshaChina 58 works

Where it is the local speciality

  1. WenzhouCN · 27.2 works6.8×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cancer Mechanisms and Therapy than the world average.

See Cancer Mechanisms and Therapy on the map

Where is the best place to study Cancer Mechanisms and Therapy?

Among universities, judged by research, Sichuan University, Harvard University and Sun Yat-sen University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.04%fractional works in this field (log) →share of work in the world top 10% →Sichuan UniversityShanghai University …Harvard UniversitySun Yat-sen University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sichuan UniversityChina 67.219.2%4.8×44 +15.6%
2Harvard UniversityUnited States 66.515.3%2.5×32 -39.5%
3Sun Yat-sen UniversityChina 65.513.0%8.9×74 +2.6%
4Shanghai University of Traditional Chinese MedicineChina 56.017.6%19.6×22 +62.3%
5Chengdu University of Traditional Chinese MedicineChina 54.819.0%11.0×11 +154.0%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 54.112.4%7.6×32 +29.7%
7Guangzhou Medical UniversityChina 51.615.9%13.2×19 +18.7%
8Zhejiang UniversityChina 46.613.1%3.3×36 -17.3%
9Shanghai Jiao Tong UniversityChina 46.412.9%3.3×38 -30.2%
10Guangzhou University of Chinese MedicineChina 45.712.0%14.6×14 +48.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cancer Mechanisms and Therapy, country by country

Is Cancer Mechanisms and Therapy research growing?

Output in 2022-2025 was 7% lower than in 2018-2021, peaking in 2020.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cancer Mechanisms and Therapy as a percentage of every work published that year, 0.019% in 2024.

still counting0.010%0.020%0.030%Cancer Mechanisms and Therapy0.017% in 202519801990200020102020

Fractional works of Cancer Mechanisms and Therapy over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cancer Mechanisms and Therapy10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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