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Most cited papers in Biotin and Related Studies

What are the most cited papers in Biotin and Related Studies?

The most cited paper in Biotin and Related Studies is "An automated method for finding molecular complexes in large protein interaction networks" (Gary D. Bader, Christopher W.V. Hogue, 2003), with 6,387 citations. Next come "A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae" (4,754) and "The determination of enzyme inhibitor constants" (4,083).

Showing 50 of 101 papers. Every paper with more than 873 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 An automated method for finding molecular complexes in large protein interaction networks Gary D. Bader, Christopher W.V. Hogue · BMC Bioinformatics Open access 13 Jan 2003 6,387
2 A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae Peter H Uetz, Loïc Giot, Gerard Cagney et al. · Nature Feb 2000 4,754
3 The determination of enzyme inhibitor constants Martin Dixon · Biochemical Journal Open access Aug 1953 4,083
4 Sulforhodamine B colorimetric assay for cytotoxicity screening Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols Aug 2006 3,730
5 A comprehensive two-hybrid analysis to explore the yeast protein interactome Takashi Ito, Tomoko Chiba, Ritsuko Ozawa et al. · Proceedings of the National Academy of Sciences Open access 13 Mar 2001 3,602
6 The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins William H. Landschulz, Peter F. Johnson, Steven Lanier McKnight · Science 24 Jun 1988 3,521
7 Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin Atsushi Miyawaki, Juan Llopis, Roger Heim et al. · Nature 28 Aug 1997 3,272
8 Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J L Cordell, Brunangelo Falini, Wendy N. Erber et al. · Journal of Histochemistry & Cytochemistry Feb 1984 3,212
9 A Fast Flexible Docking Method using an Incremental Construction Algorithm Matthias Rarey, BERND J. KRÄMER, Thomas Lengauer et al. · Journal of Molecular Biology Aug 1996 2,848
10 Severe Psoriasis – Oral Therapy with a New Retinoid Tove Fredriksson, U. Pettersson · Dermatologica 14 Oct 2009 2,758
11 HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis Georgyi V. Los, Lance P. Encell, Mark G. McDougall et al. · ACS Chemical Biology Jun 2008 2,688
12 SNAREs — engines for membrane fusion Reinhard Jahn, Richard H. Scheller · Nature Reviews Molecular Cell Biology ReviewOpen access 16 Aug 2006 2,675
13 A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells Kyle J. Roux, Dae In Kim, Manfred Raida et al. · The Journal of Cell Biology Open access 12 Mar 2012 2,636
14 Dynamic strength of molecular adhesion bonds Erastus W. Evans, Ken P. Ritchie · Biophysical Journal Open access Apr 1997 2,582
15 Efficient Trace-labelling of Proteins with Iodine Arthur Sproul McFarlane · Nature 5 Jul 1958 2,560
16 Pathview: an R/Bioconductor package for pathway-based data integration and visualization Weijun Luo, Cory Brouwer · Bioinformatics Open access 4 Jun 2013 2,487
17 A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome Ulrich Stelzl et al. · Cell Open access Sep 2005 2,439
18 A rapid radiochemical method for the determination of choline acetyltransferase Frode Fonnum · Journal of Neurochemistry Feb 1975 2,403
19 Efficient proximity labeling in living cells and organisms with TurboID Tess Caroline Branon, Justin A. Bosch, Ariana D. Sanchez et al. · Nature Biotechnology Open access 20 Aug 2018 2,338
20 Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. G M Brodeur, Jon Pritchard, Frank Berthold et al. · Journal of Clinical Oncology Aug 1993 2,327
21 Mechanisms of intracellular protein transport James Edward Rothman · Nature Nov 1994 2,298
22 A general method for the covalent labeling of fusion proteins with small molecules in vivo Antje Keppler, Susanne Gendreizig, Thomas Gronemeyer et al. · Nature Biotechnology Open access 9 Dec 2002 2,042
23 PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences Fang L. Zhang, Patrick J. Casey · Annual Review of Biochemistry Jun 1996 2,029
24 Reaching for high-hanging fruit in drug discovery at protein–protein interfaces James A. Wells, Christopher L. McClendon · Nature Open access Dec 2007 1,989
25 Heterologous protein expression in the methylotrophic yeast Pichia pastoris Joan Lin Cereghino, James M. Cregg · FEMS Microbiology Reviews 2000 1,968
26 STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data Damian Szklarczyk, Alberto Santos, Christian von Mering et al. · Nucleic Acids Research Open access 20 Nov 2015 1,791
27 Fluorescence detection in automated DNA sequence analysis Lloyd M. Smith, Jane Z. Sanders, Robert Kaiser et al. · Nature Jun 1986 1,720
28 The leucine-rich repeat as a protein recognition motif Boštjan Kobe · Current Opinion in Structural Biology Dec 2001 1,705
29 THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT A. G. E. Pearse · Journal of Histochemistry & Cytochemistry May 1969 1,686
30 Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A Han G. Brunner, Marcel R. Nelen, Xandra Owens Breakefield et al. · Science 22 Oct 1993 1,661
31 A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies Su-Ming Hsu, Laurence Raine, Herbert Fanger · American Journal of Clinical Pathology May 1981 1,655
32 Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae Scott B. Ficarro, Mark L. McCleland, P. Todd Stukenberg et al. · Nature Biotechnology Mar 2002 1,642
33 Architecture of the human interactome defines protein communities and disease networks Edward L. Huttlin et al. · Nature Open access May 2017 1,587
34 Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation Chang-Deng Hu, Yurii V. Chinenov, Tom Klaus Kerppola · Molecular Cell Open access Apr 2002 1,580
35 Bioanalytical Method Validation—A Revisit with a Decade of Progress Vinod P. Shah, Kamal K. Midha, John W. A. Findlay et al. · Pharmaceutical Research Dec 2000 1,577
36 Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells B. Albert Griffin, Stephen Adams, Roger Y. Tsien · Science 10 Jul 1998 1,564
37 Directed evolution of APEX2 for electron microscopy and proximity labeling Stephanie S Lam, Jeffrey D. Martell, Kimberli J. Kamer et al. · Nature Methods Open access 24 Nov 2014 1,498
38 PRODIGY: a web server for predicting the binding affinity of protein–protein complexes Li C. Xue, João Pglm Rodrigues, Panagiotis L. Kastritis et al. · Bioinformatics Open access 8 Aug 2016 1,484
39 Statin-Associated Myopathy Paul D. Thompson, Priscilla M. Clarkson, Richard H. Karas · JAMA Apr 2003 1,453
40 THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN Bo Hallgren, Patrick Sourander · Journal of Neurochemistry Oct 1958 1,453
41 Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein Steve M. Read, D. H. Northcote · Analytical Biochemistry Sep 1981 1,428
42 Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging Jeffrey D. Martell, Alice Y. Ting, Hyun‐Woo Rhee et al. · DSpace@MIT (Massachusetts Institute of Technology) Open access Sep 2012 1,417
43 A network of protein–protein interactions in yeast Benno Schwikowski, Peter H Uetz, Stanley Fields · Nature Biotechnology Dec 2000 1,386
44 Protein Radicals in Enzyme Catalysis JoAnne Stubbe, Wilfred A. van der Donk · Chemical Reviews Review 19 Mar 1998 1,383
45 CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks Yu Fei Tang, Min Li, Jianxin Wang et al. · Biosystems 17 Nov 2014 1,358
46 Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB Karen K. Yamamoto, Guillermo Avalos Gonzalez, William Biggs et al. · Nature Aug 1988 1,324
47 Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry Benjamin F. Cravatt, Aaron Wright, John W. Kozarich · Annual Review of Biochemistry Review 26 Mar 2008 1,295
48 A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids MK Gaitonde · Biochemical Journal Open access Aug 1967 1,234
49 Structural Origins of High-Affinity Biotin Binding to Streptavidin Patricia C Weber, D.H. Ohlendorf, John J. Wendoloski et al. · Science 6 Jan 1989 1,228
50 Structure-Function Relationships in the Vitamin D Endocrine System* R. Bouillon, William H. Okamura, Anthony W. Norman · Endocrine Reviews Apr 1995 1,199

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.