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Topic · Cell Biology

Biotin and Related Studies

Biotin and Related Studies is a research topic within Cell Biology. Science Explorer counts 19k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on proximity-dependent protein labeling techniques, such as BioID and TurboID, to identify protein-protein interactions and map spatial proteomes within living cells. The use of biotin, streptavidin, and avidin-based systems for enzymatic tagging and proximity labeling is a central theme in these studies, particularly in the context of investigating cellular interactomes and organelle-specific proteomes.

  • Proximity Labeling
  • Biotin
  • Enzymatic Tagging
  • Protein-Protein Interactions
  • Spatial Proteomic Mapping
  • Mitochondria
  • BioID
  • Streptavidin
  • Avidin
  • Cellular Interactome
Research works
19k
fractional, since 1950
In the world top 10%
1.9k
per year above
Top-10% rate
10.0%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-1%
the tick is no change
Largest producer
United States
35% of the 10 largest, 2022-now
Biotin and Related Studies

Which countries lead Biotin and Related Studies research?

By volume, the United States and China publish the most (469 and 310 works in 2022-now).

By volume, 2022-now

  1. 1 United States 469 works
  2. 2 China 310 works
  3. 3 Germany 142 works
  4. 4 Japan 93 works
  5. 5 India 89 works
  6. 6 United Kingdom 73 works
  7. 7 France 53 works
  8. 8 Canada 52 works
  9. 9 South Korea 40 works
  10. 10 Italy 38 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 34.5%China: 22.8%Germany: 10.4%Japan: 6.8%6 others listed: 25.4%35%largest
United States469 · 34.5%China310 · 22.8%Germany142 · 10.4%Japan93 · 6.8%6 others listed345 · 25.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Biotin and Related Studies research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Biotin and Related Studies research, followed by Harvard University and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 23 works
  2. 2 Harvard UniversityUnited States 20 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 18 works
  4. 4 Russian Academy of SciencesRussia 13 works
  5. 5 Peking UniversityChina 13 works
  6. 6 National Institutes of HealthUnited States 11 works
  7. 7 Max Planck SocietyGermany 10 works
  8. 8 University of TorontoCanada 10 works
  9. 9 Zhejiang UniversityChina 10 works
  10. 10 Shanghai Jiao Tong UniversityChina 8 works

Who are the leading researchers in Biotin and Related Studies?

The most-cited researchers publishing on Biotin and Related Studies include Peer Bork, Matthias Mann and John Q. Trojanowski.

  1. 1 Peer Bork Germany 396k citations
  2. 2 Matthias Mann Germany 308k citations
  3. 3 John Q. Trojanowski United States 286k citations
  4. 4 Chris Sander United States 276k citations
  5. 5 Hagop M. Kantarjian United States 273k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Biotin and Related Studies?

The most cited paper in Biotin and Related Studies is "An automated method for finding molecular complexes in large protein interaction networks" (Gary D. Bader, Christopher W.V. Hogue, 2003), with 6,387 citations. Next come "A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae" (4,754) and "The determination of enzyme inhibitor constants" (4,083).

Most cited papers
#PaperReleasedCitations
1 An automated method for finding molecular complexes in large protein interaction networks Gary D. Bader, Christopher W.V. Hogue · BMC Bioinformatics Open access 13 Jan 2003 6,387
2 A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae Peter H Uetz, Loïc Giot, Gerard Cagney et al. · Nature Feb 2000 4,754
3 The determination of enzyme inhibitor constants Martin Dixon · Biochemical Journal Open access Aug 1953 4,083
4 Sulforhodamine B colorimetric assay for cytotoxicity screening Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols Aug 2006 3,730
5 A comprehensive two-hybrid analysis to explore the yeast protein interactome Takashi Ito, Tomoko Chiba, Ritsuko Ozawa et al. · Proceedings of the National Academy of Sciences Open access 13 Mar 2001 3,602
All 101 most cited papers, with filters and sorting

Where is Biotin and Related Studies research done?

The largest centres of Biotin and Related Studies research in 2022-now are Beijing (China), Shanghai (China), Hangzhou (China) and Tokyo (Japan).

Largest cities, 2022-now

  1. 1 BeijingChina 66 works
  2. 2 ShanghaiChina 25 works
  3. 3 HangzhouChina 24 works
  4. 4 TokyoJapan 23 works
  5. 5 ParisFrance 23 works
  6. 6 LondonUnited Kingdom 19 works
  7. 7 MoscowRussia 18 works
  8. 8 New YorkUnited States 17 works
  9. 9 BostonUnited States 16 works
  10. 10 SeoulSouth Korea 16 works
See Biotin and Related Studies on the map

Where is the best place to study Biotin and Related Studies?

Among universities, judged by research, Peking University, Harvard University and University of Toronto score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 18.05%fractional works in this field (log) →share of work in the world top 10% →Peking UniversityHarvard UniversityUniversity of TorontoZhejiang University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Peking UniversityChina 74.133.6%4.1×13 +94.1%
2Harvard UniversityUnited States 71.214.6%3.9×20 +36.9%
3University of TorontoCanada 25.212.0%3.1×10 -10.3%
4Zhejiang UniversityChina 10.012.0%2.4×10 +62.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Biotin and Related Studies, country by country

Is Biotin and Related Studies research growing?

Output in 2022-2025 was 1% lower than in 2018-2021, peaking in 2025.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Biotin and Related Studies as a percentage of every work published that year, 0.0066% in 2024.

still counting0.025%0.050%0.075%Biotin and Related Studies0.0077% in 202519801990200020102020

Fractional works of Biotin and Related Studies over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Biotin and Related Studies10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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