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Topic · Cell Biology

Endoplasmic Reticulum Stress and Disease

Endoplasmic Reticulum Stress and Disease is a research topic within Cell Biology. Science Explorer counts 34k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular mechanisms, regulation, and consequences of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). It explores the role of ER stress in various diseases such as diabetes, cancer, neurodegenerative diseases, and liver disease, highlighting its impact on cell fate decisions, protein folding, oxidative stress, and apoptosis. The cluster also delves into the involvement of UPR pathways, chaperones, and the interplay between ER stress and inflammation.

  • Endoplasmic Reticulum
  • Stress
  • Unfolded Protein Response
  • ER Stress
  • Cell Death
  • Protein Folding
  • UPR Pathways
  • Oxidative Stress
  • Apoptosis
  • Chaperones
Research works
34k
fractional, since 1950
In the world top 10%
3.3k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+6%
the tick is no change
Largest producer
China
45% of the 10 largest, 2022-now
Endoplasmic Reticulum Stress and Disease

Which countries lead Endoplasmic Reticulum Stress and Disease research?

By volume, China and the United States publish the most (2.4k and 1.4k works in 2022-now).

By volume, 2022-now

  1. 1 China 2.4k works
  2. 2 United States 1.4k works
  3. 3 Japan 319 works
  4. 4 India 261 works
  5. 5 Germany 241 works
  6. 6 South Korea 191 works
  7. 7 United Kingdom 181 works
  8. 8 Italy 164 works
  9. 9 France 154 works
  10. 10 Canada 120 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 44.8%United States: 25.1%Japan: 5.9%India: 4.8%6 others listed: 19.4%45%largest
China2,434 · 44.8%United States1,366 · 25.1%Japan319 · 5.9%India261 · 4.8%6 others listed1,052 · 19.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Endoplasmic Reticulum Stress and Disease research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Endoplasmic Reticulum Stress and Disease research, followed by Sun Yat-sen University and Harvard University.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 61 works
  2. 2 Sun Yat-sen UniversityChina 55 works
  3. 3 Harvard UniversityUnited States 55 works
  4. 4 Shanghai Jiao Tong UniversityChina 53 works
  5. 5 Zhejiang UniversityChina 49 works
  6. 6 Huazhong University of Science and TechnologyChina 42 works
  7. 7 Wuhan UniversityChina 41 works
  8. 8 Centre National de la Recherche ScientifiqueFrance 41 works
  9. 9 Sichuan UniversityChina 40 works
  10. 10 Central South UniversityChina 40 works

Who are the leading researchers in Endoplasmic Reticulum Stress and Disease?

The most-cited researchers publishing on Endoplasmic Reticulum Stress and Disease include Eric S. Lander, Mark J. Daly and Peer Bork.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Peer Bork Germany 396k citations
  4. 4 Guido Kroemer France 386k citations
  5. 5 Gad A. Getz United States 364k citations
  6. 6 Shizuo Akira Japan 342k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Giuseppe Remuzzi Italy 328k citations
  9. 9 Matthias Mann Germany 308k citations
  10. 10 Richard A. Gibbs United States 292k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Endoplasmic Reticulum Stress and Disease?

The most cited paper in Endoplasmic Reticulum Stress and Disease is "Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice" (Yi Chen, Lei Wang, Qiuxiang Kang et al., 2017), with 10,709 citations. Next come "Autophagy fights disease through cellular self-digestion" (6,507) and "Signal integration in the endoplasmic reticulum unfolded protein response" (6,391).

Most cited papers
#PaperReleasedCitations
1 Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry Open access 2017 10,709
2 Autophagy fights disease through cellular self-digestion Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature Open access Feb 2008 6,507
3 Signal integration in the endoplasmic reticulum unfolded protein response David Ron, Peter Walter · Nature Reviews Molecular Cell Biology Review 14 Jun 2007 6,391
4 The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation Peter Walter, David Ron · Science 24 Nov 2011 6,131
5 Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+ Martin D. Bootman, Ludwig Missiaen, Jan B. Parys et al. · Biochemical Journal Open access Mar 1995 5,130
All 100 most cited papers, with filters and sorting

Where is Endoplasmic Reticulum Stress and Disease research done?

The largest centres of Endoplasmic Reticulum Stress and Disease research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China).

Largest cities, 2022-now

  1. 1 BeijingChina 258 works
  2. 2 ShanghaiChina 183 works
  3. 3 GuangzhouChina 157 works
  4. 4 WuhanChina 115 works
  5. 5 NanjingChina 104 works
  6. 6 HangzhouChina 98 works
  7. 7 TokyoJapan 84 works
  8. 8 SeoulSouth Korea 80 works
  9. 9 ParisFrance 75 works
  10. 10 ChangshaChina 72 works
See Endoplasmic Reticulum Stress and Disease on the map

Where is the best place to study Endoplasmic Reticulum Stress and Disease?

Among universities, judged by research, Harvard University, Zhejiang University and Sun Yat-sen University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 14.68%fractional works in this field (log) →share of work in the world top 10% →Sichuan UniversityZhejiang UniversitySun Yat-sen UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 71.912.4%3.0×55 -4.8%
2Zhejiang UniversityChina 67.416.0%3.2×49 +47.6%
3Sun Yat-sen UniversityChina 65.713.3%4.7×55 +45.9%
4Sichuan UniversityChina 65.518.5%3.1×40 +40.7%
5Shanghai Jiao Tong UniversityChina 62.913.6%3.2×53 +43.4%
6Fudan UniversityChina 62.915.4%4.4×40 +42.0%
7Wuhan UniversityChina 61.915.7%5.0×41 +7.7%
8Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 60.914.6%5.6×34 +58.6%
9Huazhong University of Science and TechnologyChina 59.814.0%4.0×42 +36.9%
10Central South UniversityChina 59.513.3%3.6×40 +21.5%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Endoplasmic Reticulum Stress and Disease, country by country

Is Endoplasmic Reticulum Stress and Disease research growing?

Output in 2022-2025 was 6% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Endoplasmic Reticulum Stress and Disease.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Endoplasmic Reticulum Stress and Disease as a percentage of every work published that year, 0.027% in 2024.

still counting0.020%0.040%Endoplasmic Reticulum Stress and Disease0.027% in 202519801990200020102020

Fractional works of Endoplasmic Reticulum Stress and Disease over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Endoplasmic Reticulum Stress and Disease9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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