Most cited papers in Endoplasmic Reticulum Stress and Disease
What are the most cited papers in Endoplasmic Reticulum Stress and Disease?
The most cited paper in Endoplasmic Reticulum Stress and Disease is "Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice" (Yi Chen, Lei Wang, Qiuxiang Kang et al., 2017), with 10,709 citations. Next come "Autophagy fights disease through cellular self-digestion" (6,507) and "Signal integration in the endoplasmic reticulum unfolded protein response" (6,391).
Showing 50 of 100 papers. Every paper with more than 1,866 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry | 2017 | 10,709 |
| 2 | Autophagy fights disease through cellular self-digestion Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature | Feb 2008 | 6,507 |
| 3 | Signal integration in the endoplasmic reticulum unfolded protein response David Ron, Peter Walter · Nature Reviews Molecular Cell Biology | 14 Jun 2007 | 6,391 |
| 4 | The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation Peter Walter, David Ron · Science | 24 Nov 2011 | 6,131 |
| 5 | Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+ Martin D. Bootman, Ludwig Missiaen, Jan B. Parys et al. · Biochemical Journal | Mar 1995 | 5,130 |
| 6 | Protein folding and misfolding Christopher Martin Dobson · Nature | Dec 2003 | 4,808 |
| 7 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide Christian Haass, Dennis J. Selkoe · Nature Reviews Molecular Cell Biology | 24 Jan 2007 | 4,786 |
| 8 | p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry | 19 Jun 2007 | 4,649 |
| 9 | Autophagy and Viruses: Adversaries or Allies? Xiaonan Dong, Beth Levine · Journal of Innate Immunity | 2013 | 4,442 |
| 10 | Mechanisms of NAFLD development and therapeutic strategies Scott L. Friedman, Brent A. Neuschwander‐Tetri, Mary Eugenia Rinella et al. · Nature Medicine | 29 Jun 2018 | 4,390 |
| 11 | The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction Michael H. Glickman, Aaron J. Ciechanover · Physiological Reviews | Apr 2002 | 4,266 |
| 12 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond Claudio A. Hetz · Nature Reviews Molecular Cell Biology | 18 Jan 2012 | 4,252 |
| 13 | XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell | Dec 2001 | 4,139 |
| 14 | Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Taichi Hara, Kenji D. Nakamura, Makoto Matsui et al. · Nature | 19 Apr 2006 | 3,905 |
| 15 | Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes Umut Özcan, Qiong Cao, Erkan Yılmaz et al. · Science | 14 Oct 2004 | 3,878 |
| 16 | Self-eating and self-killing: crosstalk between autophagy and apoptosis Maria Chiara Maiuri, Einat Zalckvar, Adi Kimchi et al. · Nature Reviews Molecular Cell Biology | 23 Aug 2007 | 3,659 |
| 17 | Molecular chaperones in protein folding and proteostasis F. Ulrich Hartl, Andreas Bracher, Manajit K. Hayer-Hartl · Nature | Jul 2011 | 3,635 |
| 18 | Regulation Mechanisms and Signaling Pathways of Autophagy Congcong He, Daniel J. Klionsky · Annual Review of Genetics | 4 Aug 2009 | 3,612 |
| 19 | An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress Heather P. Harding, Yuhong Zhang, Huiquing Zeng et al. · Molecular Cell | Mar 2003 | 3,400 |
| 20 | Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation John M. Kyriakis, Joseph Avruch · Physiological Reviews | Apr 2001 | 3,398 |
| 21 | Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein F. Ulrich Hartl, Manajit K. Hayer-Hartl · Science | 8 Mar 2002 | 3,390 |
| 22 | Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase Heather P. Harding, Yuhong Zhang, David Ron · Nature | 21 Jan 1999 | 3,379 |
| 23 | Principles of bioactive lipid signalling: lessons from sphingolipids Yusuf Awni Hannun, Lina Marie Obeid · Nature Reviews Molecular Cell Biology | 23 Jan 2008 | 3,378 |
| 24 | MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease Mohammed Eslam et al. · Gastroenterology | 7 Feb 2020 | 3,358 |
| 25 | Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells Heather P. Harding, Isabel Novoa, Yuhong Zhang et al. · Molecular Cell | Nov 2000 | 3,335 |
| 26 | p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology | 14 Nov 2005 | 3,321 |
| 27 | Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature | 2000 | 3,278 |
| 28 | Calreticulin exposure dictates the immunogenicity of cancer cell death Michel Obéid, Antoine Tesnière, François Ghiringhelli et al. · Nature Medicine | 24 Dec 2006 | 3,191 |
| 29 | Fission and selective fusion govern mitochondrial segregation and elimination by autophagy Gilad Twig, Álvaro A. Elorza, Anthony J. A. Molina et al. · The EMBO Journal | 17 Jan 2008 | 3,144 |
| 30 | THE MAMMALIAN UNFOLDED PROTEIN RESPONSE Martin Schröder, Randal J. Kaufman · Annual Review of Biochemistry | Jun 2005 | 3,058 |
| 31 | Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1 Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science | 28 Jan 2000 | 3,021 |
| 32 | Induction of apoptosis in fibroblasts by c-myc protein Gérard I. Evan, Andrew H. Wyllie, Christopher S. Gilbert et al. · Cell | Apr 1992 | 2,982 |
| 33 | Mechanisms of hepatic stellate cell activation Takuma Tsuchida, Scott L. Friedman · Nature Reviews Gastroenterology & Hepatology | 10 May 2017 | 2,956 |
| 34 | Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). Rose M. Johnstone, Mohammed Adam, James R. Hammond et al. · Journal of Biological Chemistry | Jul 1987 | 2,926 |
| 35 | Biological Functions of Autophagy Genes: A Disease Perspective Beth Levine, Guido Kroemer · Cell | 2019 | 2,917 |
| 36 | Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Anne Bertolotti, Yuhong Zhang, Linda M. Hendershot et al. · Nature Cell Biology | 8 May 2000 | 2,917 |
| 37 | IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature | 3 Jan 2002 | 2,916 |
| 38 | Roles of CHOP/GADD153 in endoplasmic reticulum stress Seiichi Oyadomari, Masataka Mori · Cell Death and Differentiation | 19 Dec 2003 | 2,860 |
| 39 | Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease Gökhan S. Hotamışlıgil · Cell | Mar 2010 | 2,819 |
| 40 | The integrated stress response Karolina Pakos‐Zebrucka, Izabela Koryga, Katarzyna Mnich et al. · EMBO Reports | 14 Sep 2016 | 2,803 |
| 41 | Mechanisms, regulation and functions of the unfolded protein response Claudio Hetz, Kezhong Zhang, Randal J. Kaufman · Nature Reviews Molecular Cell Biology | 26 May 2020 | 2,740 |
| 42 | Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress Ira A. Tabas, David Ron · Nature Cell Biology | Mar 2011 | 2,661 |
| 43 | The stress-activated protein kinase subfamily of c-Jun kinases John M. Kyriakis, Papia T. Banerjee, Eleni Nikolakaki et al. · Nature | May 1994 | 2,620 |
| 44 | An Overview of Autophagy: Morphology, Mechanism, and Regulation Katherine R. Parzych, Daniel J. Klionsky · Antioxidants and Redox Signaling | 3 Jun 2013 | 2,585 |
| 45 | Adapting Proteostasis for Disease Intervention William E. Balch, Richard I. Morimoto, Andrew Dillin et al. · Science | 14 Feb 2008 | 2,561 |
| 46 | Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis Herbert Tilg, Alexander Rupert Moschen · Hepatology | 20 Sep 2010 | 2,557 |
| 47 | HSP90 and the chaperoning of cancer Luke J. Whitesell, Susan Lee Lindquist · Nature reviews. Cancer | 20 Sep 2005 | 2,514 |
| 48 | The amyloid state and its association with protein misfolding diseases Tuomas P. J. Knowles, Michele Vendruscolo, Christopher Martin Dobson · Nature Reviews Molecular Cell Biology | 23 May 2014 | 2,461 |
| 49 | Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes Umut Özcan, Erkan Yılmaz, Lale Özcan et al. · Science | 24 Aug 2006 | 2,444 |
| 50 | Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product Yoshizumi Ishino, Hideo Shinagawa, K Makino et al. · Journal of Bacteriology | Dec 1987 | 2,405 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.