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Topic · Cell Biology

Hippo pathway signaling and YAP/TAZ

Hippo pathway signaling and YAP/TAZ is a research topic within Cell Biology. Science Explorer counts 14k research works in it since 1952. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the role of the Hippo signaling pathway, particularly the involvement of YAP/TAZ, in mechanotransduction, cell proliferation, tissue growth control, organ size control, and its implications in cancer and stem cell regulation.

  • Hippo Pathway
  • YAP/TAZ
  • mechanotransduction
  • cell proliferation
  • tissue growth control
  • organ size control
  • cancer
  • regulation
  • mechanobiology
  • stem cells
Research works
14k
fractional, since 1952
In the world top 10%
1.4k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-4%
the tick is no change
Largest producer
China
48% of the 10 largest, 2022-now
Hippo pathway signaling and YAP/TAZ

Which countries lead Hippo pathway signaling and YAP/TAZ research?

By volume, China and the United States publish the most (1.5k and 773 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.5k works
  2. 2 United States 773 works
  3. 3 Japan 145 works
  4. 4 South Korea 112 works
  5. 5 Germany 106 works
  6. 6 United Kingdom 102 works
  7. 7 France 90 works
  8. 8 India 78 works
  9. 9 Canada 77 works
  10. 10 Italy 60 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 48.5%United States: 25.8%Japan: 4.8%South Korea: 3.7%6 others listed: 17.1%48%largest
China1,452 · 48.5%United States773 · 25.8%Japan145 · 4.8%South Korea112 · 3.7%6 others listed513 · 17.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Hippo pathway signaling and YAP/TAZ research?

By volume in 2022-now, Sun Yat-sen University publishes the most Hippo pathway signaling and YAP/TAZ research, followed by Shanghai Jiao Tong University and Sichuan University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 47 works
  2. 2 Shanghai Jiao Tong UniversityChina 46 works
  3. 3 Sichuan UniversityChina 36 works
  4. 4 Zhejiang UniversityChina 33 works
  5. 5 Fudan UniversityChina 31 works
  6. 6 Harvard UniversityUnited States 30 works
  7. 7 Central South UniversityChina 28 works
  8. 8 Nanjing Medical UniversityChina 27 works
  9. 9 Chinese Academy of SciencesChina 24 works
  10. 10 Centre National de la Recherche ScientifiqueFrance 23 works

Who are the leading researchers in Hippo pathway signaling and YAP/TAZ?

The most-cited researchers publishing on Hippo pathway signaling and YAP/TAZ include Peer Bork, Guido Kroemer and Bert Vogelstein.

  1. 1 Peer Bork Germany 396k citations
  2. 2 Guido Kroemer France 386k citations
  3. 3 Bert Vogelstein United States 373k citations
  4. 4 Gad A. Getz United States 364k citations
  5. 5 Elaine R. Mardis United States 346k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Matthias Mann Germany 308k citations
  8. 8 Robert A. Weinberg United States 301k citations
  9. 9 Todd R. Golub United States 283k citations
  10. 10 Matthew M. Meyerson United States 280k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Hippo pathway signaling and YAP/TAZ?

The most cited paper in Hippo pathway signaling and YAP/TAZ is "Epithelial–mesenchymal transitions in tumour progression" (Jean Paul Thiery, 2002), with 6,738 citations. Next come "Role of YAP/TAZ in mechanotransduction" (6,136) and "Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery" (5,744).

Most cited papers
#PaperReleasedCitations
1 Epithelial–mesenchymal transitions in tumour progression Jean Paul Thiery · Nature reviews. Cancer Review Jun 2002 6,738
2 Role of YAP/TAZ in mechanotransduction Sirio Dupont, Leonardo Morsut, Mariaceleste Aragona et al. · Nature Open access Jun 2011 6,136
3 Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery Sandeep Robert Datta, Henryk Dudek, Xu Tao et al. · Cell Open access Oct 1997 5,744
4 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature Dec 1995 5,284
5 ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES Rosalind Kornfeld, Stuart A. Kornfeld · Annual Review of Biochemistry Jun 1985 4,883
All 100 most cited papers, with filters and sorting

Where is Hippo pathway signaling and YAP/TAZ research done?

The largest centres of Hippo pathway signaling and YAP/TAZ research in 2022-now are Shanghai (China), Beijing (China), Guangzhou (China) and Hangzhou (China).

Largest cities, 2022-now

  1. 1 ShanghaiChina 142 works
  2. 2 BeijingChina 121 works
  3. 3 GuangzhouChina 98 works
  4. 4 HangzhouChina 66 works
  5. 5 SeoulSouth Korea 61 works
  6. 6 WuhanChina 54 works
  7. 7 Xi'anChina 50 works
  8. 8 ChangshaChina 49 works
  9. 9 NanjingChina 48 works
  10. 10 ParisFrance 48 works
See Hippo pathway signaling and YAP/TAZ on the map

Where is the best place to study Hippo pathway signaling and YAP/TAZ?

Among universities, judged by research, Sun Yat-sen University, Shanghai Jiao Tong University and Harvard University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.8%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversitySun Yat-sen UniversityShanghai Jiao Tong U…Fudan University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Sun Yat-sen UniversityChina 72.317.7%7.7×47 +42.1%
2Shanghai Jiao Tong UniversityChina 66.816.0%5.4×46 +20.3%
3Harvard UniversityUnited States 61.922.2%3.2×30 -30.1%
4Fudan UniversityChina 60.612.2%6.7×31 +28.8%
5Huazhong University of Science and TechnologyChina 57.425.4%4.2×22 +2.9%
6Zhejiang UniversityChina 56.413.2%4.2×33 +13.9%
7Sichuan UniversityChina 55.29.8%5.4×36 +27.3%
8University of California San DiegoUnited States 55.025.5%4.3×12 -52.7%
9Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 54.019.9%5.8×18 +30.5%
10Soochow UniversityChina 51.416.1%6.9×20 +35.7%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Hippo pathway signaling and YAP/TAZ, country by country

Is Hippo pathway signaling and YAP/TAZ research growing?

Output in 2022-2025 was 4% lower than in 2018-2021, peaking in 2020.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Hippo pathway signaling and YAP/TAZ as a percentage of every work published that year, 0.013% in 2024.

still counting0.010%0.020%Hippo pathway signaling and YAP/TAZ0.013% in 202519801990200020102020

Fractional works of Hippo pathway signaling and YAP/TAZ over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Hippo pathway signaling and YAP/TAZ10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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